Biology Flashcards

1
Q

Semi conservative replication

A

2 DNA strands unzip and each are a template for complementary nucleotides to form new strands ( 2 identical chromosomes)

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2
Q

Topoisomerases

A

Relax supercoiling

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3
Q

Helicase

A

Disrupts H-bonds between bases which unzips DNA

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4
Q

DNA primase

A

Forms short RNA primer which initiates binding of DNA polymerase to parent strands

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5
Q

DNA polymerase

A

Binds to parent strand and travels 5’ to 3’

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6
Q

Parent strands are antiparallel which means?

A

DNA polymerases want to go in opposite directions

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7
Q

Leading strand is synthesized __________?

A

Continuously

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8
Q

Lagging strand is synthesized in ___________?

A

Okazaki fragments ( 200-2000 base pairs separated by 50 base pair gaps )

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9
Q

Ligase fills gaps between __________?

A

Okazaki fragments

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10
Q

_______________ replaces RNA primer with DNA nucleotides

A

Another DNA polymerase

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11
Q

DNA

A

Single origin of replication and 2 replication forks move in opposite directions around chromosome

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12
Q

Eukaryotic DNA

A

Multiple linear chromosomes sopercoiled around histone proteins, multiple origins of replication

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13
Q

Telomeres

A

Numerous at ends of eukaryotic chromosomes and prevent damage to coding regions

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14
Q

________ lost from ends of chromosomes with each replication

A

1

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15
Q

When the last telomere is lost, more replication causes chromosome damage which is associated with?

A

Aging

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16
Q

Centromere

A

Area of a eukaryotic chromosome with repeating bases

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17
Q

__________ remain connected at the centromere until disjunction in mitosis or meiosis

A

2 sister chromatids

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18
Q

Okazaki fragments are much shorter in eukaryotes because of differences in ______?

A

Polymerases

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19
Q

Transcription ______ to ______?

A

DNA to RNA

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20
Q

Translation ______ to __________?

A

RNA to amino acids sequence of proteins

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21
Q

______ of genome transcribed

A

Only a fraction

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22
Q

Transcribed section of genome?

A

Gene

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23
Q

Adjacent genes expressed together? (name)

A

Operon

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24
Q

3 steps of Transcription?

A

Initiation, Elongation, and Termination

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25
Transcription: Initiation
Transcription factors bind to the promoter site (TATA box) at start of gene
26
___________ binds to a protein initiation factor to be activated
RNA polymerase
27
Transcription: elongation
Helicase unwinds gene from nucleosome (histones) and unzips
28
RNA polymerase disrupts __________ between base pairs
H- bonds
29
RNA polymerase travels
3’ to 5’
30
Transcription: termination
RNA polymerase reaches terminator poly-A sequence, releases primary mRNA transcript
31
Prokaryotes: mRNA translated to ________ by____________ in__________ ?
Protein Ribosomes Cytoplasm
32
Eukaryotes: mRNA posttranscriptionally modified by________?
miRNA
33
5' ___________ added to 5’ end of the _________________ Poly-A tail added to __________end
Guanine cap. Primary transcript 3’
34
snRNPs “snurps”
Small nuclear ribonucleoproteins 
35
miRNA
microRNA
36
Spliceosomes
Large ribonucle o protein complexes with RNA loops, assembled from snRNPs and proteins
37
Introns
X
38
Exons
X
39
98% of human genome is _________________
Noncoding sequences
40
Noncoding sequences: __________, __________, and __________
Regulate gene expression Are transposons (jumping genes) Have no known function
41
tRNA, rRNA, and other small regulatory or catalytic RNAs are NOT ________________
Translated
42
Every 3 nucleotides in mRNA
Codon
43
Each codon codes for an __________?
Amino acid
44
Short RNAs, form 3 loop Cloverleaf structure and at the end of the middle loop is an anti-codon
tRNA
45
Determines amino acid attachment to tRNA, and complementary to mRNA codon
Anti-codon
46
tRNA is transported to___________?
Cytoplasm
47
Enzymes attach specific__________________ to each tRNA
Amino acid
48
Complex protein/RNA structures that catalyze translation of the nucleotide sequence of mRNA into amino acid sequence of proteins
Ribosomes
49
Composed of two subunits, one large and one small, made of RNA and proteins (Subunits transcribed and assembled in nucleus and then exported to ER or cytoplasm)
Ribosomes
50
Ribosomes: small subunit binds to ________________?
mRNA
51
Ribosomes: large subunit, 3 active sites ?
A : binds to 1st Aminoacyl tRNA P : binds to 2nd tRNA by peptide binds E : where 1st tRNA exits
52
Translation: 3 steps - ___________ ,__________, & ___________
Initiation Elongation Termination
53
____________ : small ribosomal subunit binds 5' end of mRNA -> initiator tRNA binds to AUG mRNA start codon -> large ribosomal subunit binds to small subunit, with initiator tRNA in the "P" site of the ribosome
Initiation
54
__________ : new tRNA (complementary to 2nd codon) binds in "A" site of ribosome -> ribosome shifts 3 base pairs toward 3' end of mRNA -> "P" site tRNA is ejected and a peptide bond forms between the 1st and 2nd amino acids -> 2nd tRNA is now in "P" site with a dipeptide attached -> new tRNA binds to "A" site -> elongation repeats itself
Elongation
55
__________ : ribosome reaches stop codon -> protein release factors bind to codon and release polypeptide -> ribosome disassemble
Termination
56
__________ : cleave initiator methionine ; cleave preproteins into polypeptides or add ligands (glycosylation, methylation, phosphorylation)
Posttranslation protein modification
57
_____________ - "words" in DNA/RNA language - translated into amino acids, the protein language - 3 nucleotides long with 4 bases - 4^3 or 64 possibilities
Codons
58
________________ - complementary to DNA codons (except U replaces T)
mRNA codons
59
The 3 stop codons ________, ________, & ________. - trigger end of translation and ribosomal separation - do not bind to amino acids
UAA UAG UGA
60
______ (#) tRNAs bind specifically to one of 20 amino acids
61
61
________________ - evolution favors genetic code in which changes in 3rd base position do no result in a change in amino acid sequence (protects from nearly 1/3 of possible mutations) - example GAU, GAC, GAG, & GAA all code for alanine
Redundancy in genetic code
62
________________ single base deletions/insertions can cause transcription frame shift -> entire gene past the mutation no longer codes for the correct protein
Reading frame mutations
63
Genes are regulated through ________ feedback (activation or induction) or ________ feedback (repression)
Positive Negative
64
Switching __________ on/off is key to development and differentiation
Genes
65
____________ is a sequence of DNA containing a cluster of genes under the control of a single promoter - gene regulation in prokaryotes - promoter region, operator region, and several genes related to a particular pathway
Operon
66
__________ is binding site for RNA polymerase in Operon
Promoter
67
__________ is on/off switch in Operon
Operator
68
______ operon (E.coli lactose digestion positive feedback repressor protein binds to operator -> lactose binds repressor protein, altering its shape -> releasing protein from operator -> RNA polymerase transcribes lac operon genes -> when lactose is gone, repressor rebinds to operator halting expression
lac
69
________ operon (enzymes to synthesize tryptophan) negative feedback repressor protein binds to operator when it combines with tryptophan (when tryptophan is abundant)
trp
70
Acetylation of histones in nucleosome cause DNA to _________ - genes can be expressed
Uncoil
71
Deacetylation/Methylation os histones causes DNA to __________ - stop genes expression
Supercoil
72
____________ - proteins bind to promoter to start transcription
Transcription factors
73
____________ - DNA sequences that interact with promoter to allow expression
Control elements
74
Groups of control elements are called __________
enhancers
75
____________ bind enhancers and transcription factors which form initiation complex with RNA polymerase at promoter
Mediator proteins
76
____________ bind near the promoter, preventing the initiation complex or RNA polymerase binding
Repressor proteins
77
____________ - increases gene expression - plays critical role in evolution because one version can remain intact while the other changes (genetic drift)
Gene duplication
78
____________ can interfere with transcription or mRNA to stop translation
small noncoding RNAs
79
____________ a DNA molecule coiled around histone proteins (chromatin)
Eukaryotic chromosome
80
Human chromosome has about ____________ million base pairs (bp)
50 - 250 million
81
____________ about 200 base pairs wrapped around each histone
Nucleosome
82
____________ - uncoiled areas of a chromosome - active gene expression - light colored in stained microscope images
Euchromatin
83
____________ - DNA tightly supercoiled - darkly stained (microscope images)
Heterochromatin
84
____________ - repetitive noncoding DNA at ends of each chromosome - protect coding regions from damage over time
Telomeres
85
____________ - DNA sequences - stay connected after replication - hold 2 sister chromatids together until disjunction in mitosis or meiosis
Centromere
86
____________ - fibers attach to the chromatids at the centromere
Kinetichore
87
______________________ - alteration of naturally occurring genomes in organisms for medical, pharmaceutical, agricultural, environmental, or general research purposes - genes isolated from one species or novel genes used to transform another species - human insulin gene was inserted into E.coli to create insulin-producing bacteria
Recombinant DNA technology (biotechnology, genetic engineering or modification)
88
____________ - inserting foreign DNA into a plasmid (extrachromosomal DNA) or bacteriophage virus -> transforms the bacteria - genes of interest linked to a marker (ex: antibiotic resistance, phosphorescence) -inserting foreign DNA into the plasmid or viral genome uses restriction enzymes which cleave DNA at specific sequences where the ends of segments are offset by several bases -> projecting bases (sticky ends) reanneal with foreign DNA in the plasmid or viral DNA
Bacterial transformation
89
____________ - use different restriction enzymes to cut genomes into segments -> separated by electrophoresis -> used to locate/isolate specific genes
DNA libraries
90
____________ - made using reverse transcriptase & DNA polymerase to make DNA from mRNA - a specific cDNA library reflects proteins synthesized by a cell at that stage in the cell cycle, a step in proteomic research or to isolate specific genes
cDNA
91
____________ - used to clone/amplify DNA sequences - requires primers (complementary to 3' ends of target strands - primers facilitate polymerization - DNA is heated, polymerized, reheated, and repolymerized, doubling the DNA each time
PCR
92
____________ - spliced next to a promoter region to assure their expression in host cells
cloned genes
93
____________ - having 2 copies of the genome - zygotes - somatic cells
diploid
94
____________ - having one copy of the genome - gametes
haploid
95
____________ - unit of heredity - sequence of DNA - codes for protein or nontranslated RNA
Gene
96
____________ - one of several variants of a gene - results from inherited mutations of a gene
Allele
97
____________ - outward expression of a trait - morphological, physiological, or behavioral
Phenotype
98
____________ - the actual combination of possible alleles of a gene
genotype
99
____________ - having 2 identical alleles of a gene
homozygous
100
____________ - having 2 different alleles of a gene
heterozygous
101
____________ - position of a gene on a chromosome
locus
102
____________ - all the genes in an individual of a species
genome
103
____________ - all the alleles of a gene or set of genes in a population
gene pool
104
____________ - shows in phenotype when homozygous or heterozygous
dominant
105
____________ - expressed only if there are 2 of the recessive alleles
recessive
106
____________ - heterozygotes show distinct or intermediate phenotype
Incomplete dominance
107
____________ - both alleles expressed - ex: ABO blood groups (AB blood)
Codominance
108
____________ - degree to which genotype is expressed in the phenotype of a fraction of population with that genotype - ex: 50-70% women with BRCA1 mutation develop breast cancer
Penetrance
109
____________ - degree of phenotype variation among individuals with same genotype
Expressivity
110
____________ - a single gene affecting several traits
Pleiotropy
111
____________ - 1 gene influencing the phenotype of another gene
Epistasis
112
____________ - Mendel noticed that results of monohybrid crosses were always a 3:1 dominant:recessive ratio - concluded that each trait was controlled by 2 copies of a gene and gametes randomly receive 1 copy of each gene
Random segregation
113
____________ - 9:3:3:1 phenotypic results of dihybrid crosses involving 2 heterozygous traits - concluded genes on separate chromosomes sort independently
Independent assortment
114
____________ - loci on the same chromosomes that do not sort independently
linked genes
115
____________ - sections of DNA from 1 chromosome crossover to its homologue, altering predicted ratios by changing linkage patterns
Recombination
116
____________ - males inherit X chromosome from mother and Y chromosome from father - males inherit X cannot be heterozygous for sex-linked traits
Sex-linkage
117
____________ - extranuclear inheritance - inherited matrilineally
mitochondrial genes
118
____________ - diploid eukaryotic cell division to produce 4 haploid gametes
meiosis
119
____________ - in diploid cell, replicated homologous pairs unite in synapse -> from tetrads comprised of 4 chromatids, connected by synaptonemal protein complex -> recombination, trading segments of paternal and maternal homologues can occur -> homologous chromosomes separate -> cell divides, forms 2 haploid cells
1st meiotic division
120
____________ - replicated chromosomes line up individually along equator -> chromatids are pulled apart and the resulting cells for 1n gametes
2nd meiotic division
121
____________ - eukaryotic cell divides, forming identical 2n cells - replicated chromosomes line up singly at equator of cell -> chromatids disjoin -> cytokinesis form daughter cells - reproduction in unicellular eukaryotes - growth & repair in multicellular eukaryotes
Mitosis
122
Cell Cycle : ________, ________, ________, ________, & ________
Interphase Prophase Metaphase Anaphase Telophase
123
____________ - in breeding experiments, normal traits without induced mutations
Wild type
124
____________ - between 2 individuals heterozygous for a gene - results in 1:2:1 genotypic and 3:1 phenotypic ratios in simple dominance genes - incomplete dominance traits yield a 1:2:1 ratio for both genotype and phenotype
monohybrid cross
125
____________ - parents heterozygous for 2 unlinked genes - 9:3:3:1 phenotypic ratio
dihybrid cross
126
____________ - a cross between a dominant individual of unknown genotype with a known recessive (if any recessive offspring, dominant parent must be heterozygous
testcross
127
____________ - breeding offspring with parent to retain desirable phenotypes
backcross
128
____________ - rates of recombination determine distances between linked genes - restriction enzyme library hybridization provides more detail - genome sequencing provides most detail
gene mapping
129
____________ - analysis of a trait through multiple generations
pedigree analysis
130
____________ - statistically determines allele frequencies in population
Hardy -Weinberg equilibrium
131
Hardy-Weinberg equilibrium conditions include, ________, ________, ________, ________ & ________ (prevent population from evolving) -if 1 or more conditions not met then population undergoes microevolution (change in allele frequencies)
large population random mating no natural selection no mutation no gene flow
132
____________ - biometric statistical methods determine allele frequencies for multiple-allele genes or polygenic traits
quantitative genetics
133
Hardy-Weinberg equilibrium p = q = p^2 = 2qp = q^2 = __ + __ = __ + ___ + __ =
p = frequency of dominant allele q = frequency of recessive allele p^2 = frequency of homozygous dominants 2qp = frequency of heterozygotes q^2 = frequency of homozygous recessives p + q = 1 p^2 + 2qp + q^2 = 1
134
____________ - fundamental unit of life capable of carrying out all life functions
Cell
135
____________ - cytoplasm, cell membrane, single circular chromosome, ribosomes - Often cell wall, flagella, or other external structures - Bacteria and Archaea - Unicellular
Prokaryotes
136
____________ - complex cells, numerous internal membrane-bound organelles, multiple complex chromosomes contained inside nucleus - Animals, Plants, & Fungi Unicellular & Multicellular Species
Eukaryotes
137
_______________ - earliest eukaryote engulfed or was invaded by smaller prokaryote which continue to function inside host cell, conferring higher fitness - Explains evolution of eukaryotes, based largely on evidence from mitochondria and chloroplasts, which contain their own DNA and ribosomes similar to those found in prokaryotes
Endosymbiosis
138
_______________ - viscous, intracellular medium - ~70% water - Biochemical/mineral solutes
Cytoplasm
139
_______________ - composed of RNA and protein - sites of proteins synthesis (mRNA translation) - suspended and cytoplasm are embedded in ER or other internal membrane
Ribosomes
140
_______________ - phospholipid bilayer - hydrophilic on both internal and external cell surfaces - hydrophobic in the membrane interior - contains cholesterol & proteins
Plasma membrane
141
_______________ - double membrane - Contains DNA and regulatory proteins
Nucleus
142
_______________ - inside nucleus - site of rRNA synthesis and ribosome assembly
Nucleolus
143
_______________ - aerobic cellular respiration - Double membrane structure - Krebs cycle occurs in matrix - Electron transport chain proteins embedded in inner membrane
Mitochondria
144
_______________ - breakdown cellular waste for export and provide digestive function - Acidic and filled with digestive enzymes (from Golgi body)
Lysosomes
145
_______________ - convoluted membrane network, dotted with ribosomes - New peptide has short amino acid sequence that signals chaperone proteins to move the peptide to destination for folding, modification, activation, & export
Rough endoplasmic reticulum (RER)
146
_______________ - lipid and carbohydrate anabolism - Ca2+ balance - detoxification
Smooth endoplasmic reticulum (SER)
147
_______________ - modifies/packages proteins for export or intracellular delivery
Golgi body
148
_______________ - oxidative enzymes catalyze fats/toxins
Peroxisomes
149
_______________ - proteins provide support, shape, intracellular, transport, so motility, cell adhesion, etc. - Microfilaments (actin) change cell shaped - Intermediate filaments secure the cytoskeleton, help in cell transport and cell adhesion - Microtubules (large hollow protein tubes) parts for motor proteins to transport organelles & rearrange shape for division
Cytoskeleton
150
_______&________ - composed of microtubules attached by basal body - motility
Cilia Flagella
151
_______________ - govern reorganization of cytoskeleton in division - similar to basal bodies
Centrioles
152
_______________ - small unchanged molecules and hydrophobic molecules diffuse through membrane - Ions and larger - Polar molecules cannot penetrate
Semipermeable plasma membrane
153
_______________ - due to random movement of molecules - No energy input
Passive transport
154
_______________ - movement of solutes in fluid from higher to lower concentration
Diffusion
155
_______________ - diffusion of water across membranes from hypotonic to hypertonic
Osmosis
156
_______________ - through transmembrane channel/carrier proteins - by molecules that cannot permeate membranes
Facilitated diffusion
157
_______________ - movement of molecules that requires expenditure of ATP energy
Active transport
158
_______________ - transport substances, through a membrane against a concentration gradient - Na+/K+ pump - Proton pump
Pump proteins
159
_______________ - engulf or expel dissolved substances or particles
Bulk transport (Endocytosis/exocytosis)
160
_______________ - connexon proteins embedded in plasma membranes of cells, conduits between the cytoplasm of each cell - ex: allow cardiac cells to coordinate contraction
Gap junctions
161
_______________ - membrane proteins anchored to Microfilaments cement cells together to form a continuous impermeable surface - ex: blood brain barrier
Tight junctions
162
_______________ - proteins hold cells together, form tissues - interstitial fluid between cells
Desmosomes
163
3 types of cell-to-cell communication _______________ _______________ _______________
Juxtacrine signaling Paracrine signaling Endocrine signaling
164
_______________ - Chemical or charge potential communication - Uses direct cell contact through gap junctions or desmosomes
Juxtacrine signaling
165
_______________ - Chemical signals between cells in close proximity - ex: Neurotransmitters between neurons and effector cells
Paracrine signaling
166
_______________ - Chemical signals via blood - Cells distant from each other
Endocrine signaling
167
_______________ - 40% of all cells - Lines the exterior of body, walls of body openings, body cavities, & glands - regulates passage of materials into or out of the tissue - Lubricates with secretions - Protects from abrasion by rapid regeneration - Secretes basement membrane of lycoprotein/collagen
Epithelial tissue
168
Epithelial tissue: Single layered = __________ Multi layered = __________ Flat = _________ Cubed = __________ Column = _________
Simple Stratified Squamous Cuboidal Columnar
169
_______________ - most abundant tissue type - Forms bones, tendon, ligaments, blood, fat, underlying skin layers, and interstitial matrix (between organs/other structures)
Connective tissue
170
Connective tissue is derived from _______________ - differentiates to cell types of blood cells, fibroblasts, adipocytes, chondrocytes, osteocytes, macrophages, mast cells
Embryonic mesenchyme
171
The connective tissue secretes ___________ made of proteins, polysaccharides, & glycoproteins
Extracellular matrix
172
3 principles of cell theory _______________ _______________ _______________
1. All living organisms are composed of one or more cells. 2. Cells are fundamental living things (viruses/organelles are not considered living) 3. All cells are products of reproduction of pre-existing cells.
173
____________ first recognized cells
'Robert Hooke
174
_______________ observed cellular reproduction, and questioned spontaneous generation of life
Anton von Leeuwenhoek
175
____________ was formulated by Schwann, Schleiden, & Virchow in 1830s although the 3rd principle was not fully accepted until Pasteurs experiments in 1850s
Cell theory
176
_______________ - 2 domains (Archaea & Eubacteria) - all Unicellular - Aerobic or anaerobic environments - Autotrophs or heterotrophs - Mostly pathogenic or symbiotic species
Prokaryotes
177
Prokaryotes Classification : Shape Spherical = __________
Coccus
178
Prokaryotes Classification : Shape Rod = __________
Bacillus
179
Prokaryotes Classification : Shape Spiral = __________
Spirillus
180
Prokaryotes Classification : Grouping Pairs = __________
Diplo
181
Prokaryotes Classification : Grouping Chains = __________
Strepto
182
Prokaryotes Classification : Grouping Branched clusters = ____________
Staphylo
183
Prokaryotes Classification : Cell Wall ____________ have thick peptidoglycan cell walls, & appear stained purple
Gram-positive
184
Prokaryotes Classification : Cell Wall __________ have thin peptidoglycan layer between 2 membranes, and appears stained red/pink (most serious pathogens because lipopolysaccharides on outer membrane’s act as powerful toxins)
Gram-negative
185
Prokaryotes Classification : Metabolism Cannot survive without O2 = ____________
Obligate aerobes
186
Prokaryotes Classification : Metabolism Cannot tolerate O2 = ____________
Obligate anaerobes
187
Prokaryotes Classification : Metabolism Respire with or without O2 = ____________
Facultative anaerobes
188
____________________ - some prokaryotes produce a protective glycoprotein or carbohydrate capsule around their cell walls - In some bacteria this forms an adhesive Biofilm
Glycocalyx
189
____________________ - a thick protein structure protects from adverse conditions
Endospore
190
____________________ - thin protein filament that helps a bacterium attach to a substrate or host cell
Fimbrae
191
____________________ - many move using one or more of the structure - a thin protein filament attached to a spinning base unit - differs in structure in mechanics from eukaryotic type (which whip back and forth) - Bacteria can reverse direction by reversing spinning
Flagella
192
____________________ - mutations that confer resistance
Antibiotic resistance
193
____________________ - prokaryotes that reproduce as quickly as every 20 minutes - The rapid reproduction rate, along with a constant rate of mutation, make bacteria, highly adaptable
Adaptability
194
____________________ - are the most ubiquitous organisms on earth, occupying all possible habitats
Prokaryotes
195
____________________ - prokaryotic DNA, circular molecule attached to plasma membrane in the Nucleoid Region - Transcription and translation occur simultaneously in the cytoplasm
Simple genomes
196
____________________ - small, circular, extragenomic DNA molecules present in the cytoplasm of prokaryotes - Often contain genes that confer antibiotic resistance
Plasmids
197
____________________ - in prokaryotes, plasmids may spliced into or out of the genomic chromosome - this process is mimicked in use of plasmids in biotechnology (recombination)
Transposons
198
____________________ - cell division in prokaryotes, simple and rapid - DNA replicates than the cell divides (starting from a single origin of replication)
Binary fission
199
____________________ - tubular proteins structures protruding from the prokaryotic cell - Function in cell-cell interactions, and as a conduit for transduction (the exchange or transfer of a copy of a plasmid from one bacterium to another)
Pili
200
____________________ - proteins encapsulating a small DNA or RNA chromosome - no metabolic or reproductive processes - take over metabolic, reproductive mechanisms of host cells - evolve in response to changes in hosts - adapt rapidly to immune responses
Viruses
201
Viruses are classified according to __________ , ____________, & ______________ .
Host type (prokaryote, or eukaryote) - host range Capsule composition and structure Nucleic acid type
202
Viruses outside the host are called ____________ .
Virions
203
____________________ - protein capsid surrounding DNA - Complex proteins tail sheath to inject, viral DNA into host bacterium - Tail fibers bond to bacterial cell wall
Bacteriophage virus
204
____________________ - misfolded proteins - enter a host, cause chain reaction of similar proteins misfolding - Creutzfeldt-Jakob & bovine spongiform encephalopathy are diseases
Prions
205
____________________ - tiny circular RNAs that infect plants, but do not contain genes - their presence in a host cell activates RNA silencing mechanisms, halting proteins synthesis
Viroids
206
____________________ - Insert their nucleic acid into host cells, co-opting cells infrastructure to synthesize viral proteins and genomes, which self assemble and exit to infect other cells
Viruses
207
Many viruses alternate between __________cycle & __________ cycle
Lytic cycle Lysogenic cycle
208
____________________ - complete takeover of the host cell transcription and translation process - Rapid production of new viruses - Rupture of host cell releases new viruses
Lytic cycle
209
____________________ - viral DNA splices into host genome - cell continues to function, copying, viral genome (prophage) with each division - Lytic cycle follows
Lysogenic cycle
210
____________________ - prophage causes harmless bacterium to become pathogenic
Lysogenic conversion
211
____________________ - viral RNA is translated on entry into cell
Eukaryotic RNA viruses
212
____________________ - RNA viruses that translate reverse transcriptase, an enzyme that synthesize DNA from RNA - the DNA can then enter a lysogenic cycle
Retroviruses
213
____________________ - A retroviral infection that infects specific cells of the human immune system, and causes acquired immunodeficiency syndrome (AIDS) - Infects helper T cells, dendritic cells, & macrophages - Helper T cell numbers decline I - Increase susceptibility to infection & certain cancers
Human immunodeficiency virus (HIV)
214
HIV is coated with __________ proteins in lipid membrane remaining from past host cell that fuses with new host cell plasma membrane, allowing viral capsid to enter
Docking
215
HIV inside the host cell (steps) - viral RNA translated by cytoplasmic ____________ - ________________ catalyzes the synthesis of DNA from the viral RNA template - ________________ catalyzing splicing of the viral DNA into host cell DNA - Virus is in __________ phase (hiding) in the host cell genome - Virus enters __________ phase producing billions of new virions, spreading throughout the hosts immune system
Ribosomes Reverse transcriptase Integrase Latent phase Lytic phase
216
____________________ - between and during cell division, cells go through distinct phases - Generation time - Time between divisions - Days in eukaryotes
Cell cycle
217
____________________ - between cell divisions - Contains 3 sub phases
Interphase
218
____________________ - transcription/translation of genes for cell growth/function
G1 phase (1st gap)
219
____________________ - DNA replication - Subphase in interphase
S phase (synthesis)
220
____________________ - similar to G1 but cell division is certain - mitosis follows this phase
G2 phase (2nd gap)
221
In cells that undergo growth arrest, terminal division followed by G1 is followed by __________ (cell continues to function but no more growth or DNA replication)
G0
222
In damaged cells, G2 is followed by ____________
Apoptosis
223
Transition between sub phases is regulated by a series of cell cycle ____________ , proteins that inhibit or prevent synthesis of enzymes that trigger the next phase.
Checkpoints
224
____________________ - asexual reproduction of unicellular eukaryotes - Development, growth, and repair in multicellular eukaryotes
Mitosis M phase
225
____________________ - Replicated chromosomes supercoil (characteristic X shape of replicated sister chromatids connected at centromere) - Nuclear membrane dissolves - Cytoskeleton rearranges microtubules grow outward from the centrioles to form mitotic spindle
Prophase
226
____________________ - Centrioles migrate to poles - Spindle fibers attach to kinetochores of each chromatid - replicated chromosomes lineup individually at equator
Metaphase
227
____________________ - disjunction - Sister chromatids split at centromere and pulled to each pole
Anaphase
228
____________________ - chromosomes uncoil then nuclear membranes form around 2 nuclei
Telophase
229
____________________ - Cell contents divide - Cleavage furrow at equator as plasma membrane pinches into 2 cells
Cytokinesis
230
____________________ - forms gametes (1n) in sexual reproducing eukaryotes
Meiosis
231
____________________ - sperm/ova - haploid (1n)
Gamete
232
____________________ - diploid (2n) - homologous pairs of each chromosome
Zygote & somatic cells
233
A human gamete has _____ chromosomes A human diploid cell has _____ chromosomes
23 46
234
Human cells have _____ autosomes & _____ sex chromosome
22 1
235
____________________ - begins with G2 germ cells in gonads - consists of 2 cell divisions
Meiosis
236
____________________ - replicated chromosomes supercoil - nuclear membrane dissolves - spindle fibers link centrioles to centromeres - homologous pairs form tetrads (4 chromatids) and process of synapsis - recombination (crossing-over) possible at Chiasmata (homologous chromatids intersect) - exchange bits of maternal/paternal chromatids
Prophase I
237
____________________ - synapsis continues - homologous chromosome pairs line up at equator
Metaphase I
238
____________________ - homologous chromosome pairs are split apart toward poles
Anaphase I
239
____________________ - reduction division (chromosome number halved) - cell completes division I - daughter cells haploid, nonidentical (chromosomes still replicated)
Telophase I
240
____________________ - similar to mitosis begins with 2 haploid cells
Meiosis II
241
____________________ - chromosomes supercoil - Nuclear membrane dissolves - Spindle forms
Prophase II
242
____________________ - chromosomes lineup individually across equator
Metaphase II
243
____________________ - chromatids split into separate on replicated chromosomes (disjunction), pulled toward poles
Anaphase II
244
____________________ - chromosomes uncondensed - nuclear membrane forms, followed by cytokinesis - result is 4 non-identical haploid gametes
Telophase II
245
____________________ - Spermatogonia line seminiferous tubules ——> - Testosterone triggers mitosis ——-> - 2n spermatocytes ——-> - Meiosis ——-> - 1n spermatids ——-> - Grow flagellum ——-> - Spermatozoa
Spermatogenesis
246
____________________ - Oogonia in ovarian follicles, outer cortex of ovary ——-> - Primary oocytes stop in metaphase II before birth ——-> - Post puberty, several follicles undergo oogenesis monthly ——-> - 1 forms of ovum - oogenesis divisions unequal, all cytoplasm in each division goes to 1 cell ——-> - Forms 3 polar bodies and 1 secondary oocyte ——-> - Becomes ovum upon fertilization
Oogenesis
247
____________________ - sperm survive up to 5 days in female reproductive tract - oocyte viable for 12-24 hours - many sperm reach ovum and uterine tube ——-> - Enzymes break down corona radiata/zona pellucida around oocyte ——-> - 1st sperm to reach oocyte membrane binds sperm receptors ——-> - Ca2+ release prevents additional sperm entry ——-> - oocyte completes meiosis II ——-> - Nuclei fuse to become 2n zygote
Fertilization
248
____________________ - zygote divides as it passes uterine tube ——-> - Forms blastocyst ——-> - Implants in ovary ——-> - Endometrial capillaries erode ——-> - Exchange nutrients/waste with maternal blood ——-> - Blastocyst hCG causes corpus luteum production of progesterone/estrogen
Implantation
249
____________________ - fetal/maternal capillaries intertwine ——-> - form placenta (fetal chorionic villi grow into endometrium) - allantois forms umbilical cord, & connects embryo to placenta
Placentation
250
True or false: No contact between maternal and fetal blood
True
251
Placenta takes oversecretion of progesterone/estrogen by ________
9 weeks
252
____________________ - ~40 weeks from 1st day of last menstruation - in 1st 9 weeks the zygote develops into embryo with limbs in early organ systems - after 9 weeks the fetal development continues until 37-40 weeks - Earlier birth is pre-term
Gestation (pregnancy)
253
____________________ - Labor, uterine contractions ——-> - Causes cervical dilation ——-> - Baby exits through vagina ——-> - Placenta separates from uterine wall and exits separately
Parturition (birth)
254
____________________ - postfertilization, the zygote divides rapidly (cleavage) by mitosis without G1 & G2 stages into a morula (solid ball of progressively smaller cells)
Morulation
255
____________________ - after 6 - 8 divisions the cells of the Morula flatten, forming a tight sphere of cells (blastula) around a fluid filled cavity (blastocoel) - blastula contains outer layer (trophoblast) and inner cell mass that becomes embryo and amniotic tissue - it’s complete by day 7 when implantation occurs
Blastulation
256
____________________ - ~day 12 the gastrula forms - cells derived from inner cell mass then divide into 3 germ layers (Ectoderm, Mesoderm, & Endoderm) - 1 part of trophoblast forms chorionic villi - 1 part of trophoblast forms archenteron - a groove (blastopore) in the archenteron becomes anus in deutrostomes - a groove (blastopore) in the archenteron becomes mouth in protostomes
Gastrulation
257
____________________ - neural tube development (chordates) - mesoderm/ectoderm cell signaling interactions cause ectoderm to form neural plate ——-> folds to become dorsal nerve cord
Neurulation
258
____________________ - 3 primary germ layers differentiate into distinct tissues and organs
Organogenesis
259
The 3 primary germ layers are : _______________ _______________ _______________
Ectoderm Mesoderm Endoderm
260
____________________ - Nervous system (also pituitary/pineal glands) - Integumentary system (mucous membranes/outer layer of skin, mouth, pharynx, anus) - Epithelial derived structures (hair, follicles, sweat/memory glands, cornea/lens) - Adrenal medulla - Neural crest cells migrate to become epithelium and portions of jaw, teeth, and heart valves
Ectoderm
261
____________________ - Bones/connective tissue ( cartilage, tendons, ligaments, blood, dermis) - Muscle - Circulatory, Lymphatic, Reproductive, Urinary systems (blood vessels, spleen, reproductive organs, kidneys, bladder, smooth muscle) - Adrenal cortex - along notochord, it forms somites ——-> become vertebral column & muscles of spine & rib cage
Mesoderm
262
____________________ - respiratory system (epithelia of trachea, bronchi, alveoli) - Digestive system (epithelia of esophagus, stomach, intestines) - Liver, Pancreas, Lining of Thymus, Thyroid/Parathyroid - Epithelial lining of urethra, bladder, & reproductive systems
Endoderm
263
Zygote is _______________ (differentiates into every cell type)
Totipotent
264
After 5th division, embryonic morula stem cells are _______________ (into 1 of 3 germ layer tissues)
Pluripotent
265
Cells later reach determined state, which means?
There is no change to different cell types
266
____________________ - process of cell specialization - Determines size, shape, metabolism, membrane, potential, & responsiveness to signals - these types of cells are genetically identical, but different genes are turned on/off at specific times in development
Differentiation
267
____________________ - through gap junctions and desmosomes results in asymmetric cell divisions with different genes expressed in daughter cells - affects gene expression in neighboring cells - effect diminishes with distance
Juxtacrine signaling
268
____________________ - occurs at various developmental stages - cell must detach from its original location and form a protrusion at the leading edge. This protrusion, called a lamellipodium, is formed by the polymerization of actin filaments. The cell then uses this protrusion to push itself forward, while the trailing edge of the cell contracts, pulling the cell forward. - As the cell moves forward, it interacts with its environment through specialized proteins called integrins, which anchor the cell to the extracellular matrix. The cell also secretes enzymes called matrix metalloproteinases, which help to break down the extracellular matrix and create space for the cell to move through. Ex : neutral crest cells migrate from neural tube to peripheral sites ——-> differentiate into distinct tissues
Cell migration
269
____________________ - differentiation of pluripotent stem cells is controlled by regulation of cell cycle, and activation or suppression of specific genes
Embryonic development
270
____________________ - changes in gene expression in 1 cell affect genes in another - sets of regulatory genes direct development and differentiation - growth factors (signaling proteins that cause inductive effects on competent cells) - transcriptional factors (Hox genes are responsible for cephalization, segmentation
Induction
271
____________________ - regrowth of damaged tissue - many differentiated cells cannot normally regenerate (muscle or nerve) - liver, bone, & skin regenerate readily
Regeneration
272
____________________ - failure of normal cells to regenerate - Eventually die
Cellular senescence
273
____________________ - programmed cell death due to cell damage - part of normal fetal development & in the postbirth uterus
Apoptosis
274
____________________ - communication by electrochemical signals - receives sensory info (sensory neurons) -----> - processes info -----> - relays response to muscles, glands, & effector cells
Nervous System
275
Neuron bundles form __________ nerves
Peripheral Nervous System (PNS)
276
Neurons & Glia form the networks of the _______________
Central Nervous System (CNS)
277
____________________ - combination of sensory & motor nerves - contains Somatic Nervous System & Autonomic Nervous System
Peripheral Nervous System
278
____________________ - conscious sensation and movement - includes reflexes
Somatic nervous system
279
____________________ - unconscious visceral senses such as detection of blood pressure or body temperature & unconscious movement - heart contraction & peristalsis
Autonomic Nervous System
280
____________________ - brain/spinal cord processes, integrates, coordinates sensory info & responses
Central Nervous System
281
____________________ - transmit info to spinal cord/brain (CNS) - afferent/inward
Sensory neurons
282
____________________ - transmit info from CNS to muscles/glands (effectors) - efferent/outward
Motor neurons
283
Processing of information occurs in _____________ of CNS
Gray matter - contains the cell bodies - Appears gray because there is no sheath insulation like axons
284
_______________ transmits info between parts of brain or between CNS & PNS
White matter - axons
285
The autonomic nervous system contains the ____________ & the ____________ .
Sympathetic nervous system and parasympathetic nervous system
286
____________________ - fight or flight sudden responses
Sympathetic nervous system
287
____________________ - rest and digest body functions
Parasympathetic nervous system
288
________________ Nervous System - Controls digestive function - Distinct from ANS
Enteric nervous system
289
____________________ - involuntary response to stimuli - bypasses cognitive part of brain - Stimulus info via afferent nerve to spinal cord gray matter (or midbrain for senses above neck) ——-> - Immediate response travels and efferent nerve to an effector - Monosynaptic reflex arc (receptor—> sensory neuron—> motor neuron—> effector) - Polysynaptic reflex arc (receptor—> sensory neuron—> CNS interneuron—> Motor neuron—> effector)
Reflex
290
3 structures of a neuron __________ __________ __________
Soma (cell body containing nucleus & organelles) Dendrites (receive stimulus) Axon (long nerve fiber that branches/terminal buds at the end)
291
____________________ - part of axon at soma - Lets signal pass, only if stimulus is sufficient
Axon hillock
292
____________________ - Gap between axon buds and next neuron - Paracrine signaling conveys info
Synapse
293
____________________ - Signal initiated, propagated by opening ion channel —-> - Changes transmembrane electrochemical potential by letting certain ions in/out
Ion channels
294
____________________ - in dendrites - Received chemical signal, open from outside
Ligand gated ion channels
295
____________________ - in the membrane of soma and axon - Electrochemical signal - Open from inside by voltage change
Voltage gated ion channels
296
____________________ - along axon, bulges of white fatty Lipoprotein secreted by certain glia - Schwann in PNS - Oligodendrocytes in CNS
Myelin sheath (lipoprotein =myelin)
297
____________________ - myelinated nerve impulse is faster, because signal jumps between gaps in myelin
Saltatory propagation
298
____________________ - gaps between myelin
Nodes of Ranvier
299
__________ matter = unmyelinated __________ matter = myelinated
Gray matter White matter
300
____________________ - most abundant cells in nervous system - Nourish, protect, & direct growth of neurons - differentiate into 3 types : astrocytes, microglia, & ependymal cells
Glial cells
301
____________________ - glial cell that supports CNS neurons
Astrocytes
302
____________________ - glial cell that protects CNS from infection
Microglia
303
____________________ - glial cell that lines CNS cavities
Ependymal cells
304
____________________ - junction between 2 neurons or neuron & effector cell
Synapse
305
____________________ - cell conveys signal - synapse
Presynaptic
306
____________________ - cell receives signal - synapse
Postsynaptic
307
2 types of synapses are __________ & __________
Chemical synapse Electrical synapse
308
____________________ - paracrine - terminal buds of presynaptic axon, synaptic cleft filled with interstitial fluid, & a postsynaptic cell (neuron or effector) - axon terminals contain vesicles filled with chemical neurotransmitters - When an action potential arrives at terminal bud, the voltage gated calcium channels open —-> - neurotransmitters cross synapse & bind to postsynaptic cell receptors that trigger continued propagation of the signal —-> - neurotransmitters are digested by enzymes or absorbed by the presynaptic neuron
Chemical synapse
309
____________________ - juxtacrine - nerve impulse is directly transmitted from one cell to the next via connexons (proteins channels at gap junctions between cells)
Electrical synapse
310
____________________ - voltage difference a Crossing Neuroal and Membrane when nerve not transmitting signal - ATP energy to maintain - Typically -70mV - Inside membrane negative relative to outside - is established by action of Na+/K+ pump - ATP used to pump Na+ ions outside cell & K+ into cell (3:2 ratio Na:K)
Resting potential
311
____________________ - dendrites receive stimulus —-> alter membrane potential - magnitude of change depends on strength of stimulus
Graded potential
312
____________________ - Na+ channels open, local membrane potential approaches 0 (depolarization) - Strong enough signal at axon hillock triggers it —-> - Voltage gated Na+ channels, open in sequence down axon —-> - Followed by repolarization due to K+ voltage gated channels opening —-> - Resting potential reestablished by Na+/K+ pumps
Action potential
313
____________________ - takes ~2 milliseconds at any point on axon - resting potential restoration (refractory period) takes 2-3 milliseconds more
Depolarization-Repolarization
314
Nerve impulses elicit either ____________ or ____________ responses in target cells
Excitatory response Inhibitory response
315
____________________ - stimulus causes Na+ channels to open —-> - membrane depolarizes —-> - favors action potential, impulse propagation
Excitatory response
316
____________________ - stimulus opens K+ or Cl- channels —-> - Hyperpolarization —-> - inhibits action potential, prevents signal propagation
Inhibitory response
317
Many neurons are capable of both responses : in brain neurons, GABA finding elicits ____________ responses and Glutamate causes ____________ responses
Excitatory Inhibitory
318
.
319
____________________ - is an all-or-nothing response (threshold) to the combination of excitatory & inhibitory responses at axon hillock - intensity of stimulus does not affect voltage change of the action potential - does increase impulses frequency
Nerve firing
320
____________________ - strength of a nerve signal can increase through multiple nerve impulses - Spatial or Temporal
Summation
321
______________ summation - many neurons at once
Spatial
322
_______________ summation - repeated impulses
Temporal summation
323
Both spatial and temporal summation increase ____________ levels
Neurotransmitter
324
____________________ - contains somatic nervous system & autonomic nervous system - 12 cranial nerve pairs (some sensory, motor, & mixed) - 31 spinal pairs (mixed)
Peripheral nervous system
325
__________ of spinal nerves innervate skin, muscle, & viscera
Rami (branches)
326
________________ nervous system - conscious sensation, voluntary movement, & reflexes
Somatic nervous system
327
________________ nervous system - contains sympathetic nervous system & parasympathetic nervous system - regulates unconscious functions - sensory info from muscles/joints/organs - controls smooth/cardiac muscle & glands
Autonomic nervous system
328
____________________ - neuronal clusters, get signals from CNS - axons —-> effector
Autonomic ganglia
329
____________________ - fighter or flight response prepares for sudden activity, fear, or excitement - increases heart rate, blood pressure, blood sugar, & breathing - Dilate pupils - Decrease blood flow to skin & digestive organs - Norepinephrine is main neurotransmitter
Sympathetic nervous system
330
____________________ - rest and digest - conserve energy, stimulate digestion/excretion, maintain heart rate, & anabolism - Acetylcholine is main neurotransmitter
Parasympathetic nervous system
331
____________________ - consists of forebrain & brainstem
Brain
332
____________________ - consists of cerebrum, limbic system, & diencephalon
Forebrain
333
____________________ (part of brain?) - consciousness - Judgment - Sensory processing - Voluntary motor control
Cerebrum
334
____________________ (part of brain?) - Primitive emotions
Limbic system
335
____________________ (part of brain?) - Thalamus - Hypothalamus - Basal ganglia (information integration) - Autonomic functions
Diencephalon
336
____________________ - consists of the midbrain, & hindbrain
Brainstem
337
_________________ (part of brain?) - auditory & visual reflexes - alertness & arousal - crosses right brain to control left side of body & left brain to control right side of body
Midbrain
338
____________________ (part of brain?) - includes pons - nerve fibers between forebrain, spinal cord, & cerebellum
Hindbrain
339
____________________ (part of brain?) - Upper part of spinal cord - Information from diencephalon regulates autonomic functions
Medulla oblongata
340
____________________ (part of brain?) - controls body position, muscle movement, & balance
Cerebellum
341
____________________ - inside vertebral column - myelinated tracts of white matter surrounding gray matter - afferent neurons enter dorsally & synapse with interneurons —-> - efferent motor neurons exiting ventrally - conveys information to & from brain
Spinal cord
342
____________________ - largest part of brain - divided into hemispheres - sense & control opposite sides of body (contralateral) - cerebral cortex (convoluted outer, gray matter, & divided into 4 lobes) - white matter under cortex controls impulse transmission to & from the cortex
Cerebrum
343
_________________ - functions = voluntary movement, sensory processing, olfaction, language, communication, learning, memory, & association
Cerebral cortex functions
344
2 inner cerebral structures are the _______________ & _______________
Limbic system Hippocampus
345
___________ System - contains amygdala - functions = autobiographical memory, social processing, & emotion
Limbic system
346
__________________ (part of brain?) - functions = long-term memory, spatial memory, & navigation
Hippocampus
347
____________________ - contains the thalamus, basal ganglia, hypothalamus, & epithalamus (pineal gland)
Diencephalon
348
__________&__________ - route sensory info to the cerebral cortex
Thalamus & basal ganglia
349
____________________ - collects homeostatic sensory info & provides nervous & endocrine control of the pituitary
Hypothalamus
350
____________________ - connects limbic system to rest of brain, secretes melatonin, & controls circadian rhythms
Epithalamus (pineal gland)
351
____________________ - information to CNS about internal & external environments - sensory receptors stimulate afferent neurons with excitatory or inhibitory graded potentials - if stimulation is above threshold for depolarization (excitatory) or hyperpolarization (inhibitory) —-> - impulses propagate through peripheral nervous system to central nervous system
Senses
352
____________________ - exteroception - touch, temperature, pain, pressure, taste, smell, site, hearing, balance, & motion - sensory cells stimulate afferent nerves of somatic nervous system
External senses
353
____________________ - interoception - blood sugar, salt, pH, CO2, blood pressure, long extension, gag, reflex, tendon/ligament proprioception, deep pressure, & pain
Internal physiological senses
354
____________________ - A major brain function is to integrate signals from different senses - Ex : kinesthetic awareness is knowing body position by integrating multiple senses (motion sickness is a failure to integrate visual & balance senses)
Multisensory integration
355
____________________ - fluid filled spherical organ - viscous aqueous humor fills the space between lens & cornea - virtuous humor gel fills behind lens - ciliary muscles attached to lens by suspensory ligaments & change lens shape to focus (accommodation)
Eye
356
The fibrous tunic (outer layer) forms the ________ & the _________.
Cornea White sclera
357
The vascular tunic (middle layer) of the eye supplies nutrients/O2 two adjacent layers and forms the _______________ , _______________ , & _____________ .
Choroid Ciliary muscle Iris
358
____________________ - smooth muscle that forms the pupil
Iris
359
The nervous tunic (inner layer) of the eye forms the ____________ .
Retina
360
____________________ - contains photoreceptors (rods/cones) - contains bipolar cells, horizontal cells, & amacrine cells - contains optic nerve ganglionic cells
Retina
361
____________________ - concentrated along margins of retina - detect low light without color
Rods
362
____________________ - concentrated in back of retina - detect color - when exposed to light, pigments reduce inhibitory neurotransmitters, which allows signals to propagate along optic nerve to brain (processed and visual cortex of occipital lobe) - some neurons convey information to the midbrain to control iris & ciliary muscles
Cones
363
____________________ - contains auricle & auditory canal - ending with the tympanum which vibrates in response to air vibrations (sounds)
External ear
364
____________________ - air filled, mucus lined chamber between tympanum & inner ear - 3 tiny bones (ossicles) convey sound to oval window
Middle ear
365
What are the three tiny bones of the middle ear? _____________ _____________ _____________
Maleus Incus Stapes
366
____________________ - vibrations, transmitted to fluid filled vestibule & cochlea —-> - inner hairs on cochlear organ of Corti vibrate with sound frequency —-> - convey signal to cochlear nerve
Inner ear
367
Auditory input travels from cochlear nerve to the ____________ through the ____________ to auditory cortex on the temporal lobe
Medulla Thalamus
368
____________________ - hairs on the inner ear vestibule & semicircular canals detect head position & movement respectively —-> send a signal to cerebellum - Integrated with proprioceptor & visual information in the cerebral cortex
Balance (equilibrium)
369
________ in skin detect pain & temperature
Nerves
370
_______________ sense hair motion
Follicle receptors
371
Cells in _____________ detect touch
Lower epidermis
372
Skin _______/________ detect deep pressure
Meissner/Pacinian corpuscles
373
____________ detect dissolved molecules in olfaction
Chemoreceptors
374
Thousands of distinct receptor proteins on olfactory receptor cells cilia trigger metabolic cascades when activated, which send signals to ______________ neurons, then send info to ______________ and _______________
Olfactory bulb neurons Frontal lobe Limbic system
375
Taste buds on _____________ contain taste cells
Tongue papillae
376
Food chemicals bind to receptor proteins, then neurotransmitters depolarize sensory neurons which send signals to the __________ & __________ .
Medulla Thalamus
377
The 5 primary tastes are __________ , __________ , __________ , __________ , & __________ .
Sweet Salty Sour Bitter Umami (savory taste associated with Glutamate)
378
____________________ - chemicals released by presynaptic cells, trigger response to postsynaptic cells - Include amino acids, peptides, purines, lipids, & inorganic gases such as CO & N2O - Vary in location, duration, & type of elicited stimulus
Neurotransmitters
379
____________________ - specific to a particular neurotransmitter - elicit either inhibitory responses or excitatory responses
Receptors
380
____________________ - opens ligand-gated channels or triggers complex mechanisms
Neurotransmitter/receptor binding
381
____________________ (neurotransmitter) - neuromuscular junctions —-> muscle contraction - Toxins prevent it’s breakdown (tetanus & strychnine)
Acetylcholine (ACh)
382
____________________ (neurotransmitter) - brain —-> learning/memory & reward
Dopamine
383
____________________ (neurotransmitter) - brain —-> alertness & arousal
Norepinephrine
384
____________________ (neurotransmitter) - CNS—-> good mood, appetite, sleep, & learning/memory
Serotonin
385
____________________ (neurotransmitter) - brain —-> learning/memory
Glutamate
386
____________________ (neurotransmitter) - CNS —-> reduce pain, inhibit GABA & increase glutamate - Natural opiate
Endorphins
387
____________________ (neurotransmitter) - senses & brain —-> sleep (caffeine competes) & pain reception (sensory)
Adenosine
388
____________________ (neurotransmitter) - brain —-> inhibitory - alcohol binds to receptors
GABA
389
____________________ - Mental processing/thought - Working memory, language, comprehension & production - Calculation, reasoning, & decisions - Conscious or unconscious - Heredity & epigenetic neural development influence
Cognition
390
____________________ - awareness of cognitive/physical self & environment - Multiple areas of CNS & sensory peripheral nerves
Consciousness
391
____________________ - knowledge, skills, & ideas - Conscious or unconscious - Involves sensation, memory, & habituation (conditioning)
Learning
392
____________________ - primary auditory, but also visual & physical (symbols for encoding & sharing information) - Processing mostly regulated by Broca’s area / Wernicke’s area in frontal & temporal lobes
Language
393
____________________ - interaction of diaphragm, larynx, glottis, sinuses, tongue, mouth, teeth, & lips
Speech
394
____________________ - Encoding : receive, process, & integrate information - Storage : glutamate mediated synaptic patterns record info in a retrievable form - Retrieval : consciously or unconsciously retransmitting stored memory
Memory
395
3 types of memory are, _______________ , _______________ , & _______________ .
Sensory memory Short term memory Long-term memory
396
_____________ memory - < 1s - immediate recall - no cognitive control
Sensory memory
397
_____________ memory - < 1 min - transient neuronal patterns
Short term memory
398
_____________ memory - indefinite duration - stable changes in synaptic connections, thresholds, & intensity among >100 billion neurons in many parts of the brain
Long term memory
399
Neural plasticity leads to __________________
Long term potentiation
400
____________________ - consolidates new memories - key to storing/retrieving autobiographical memory (things you’ve done/had)
Hippocampus
401
___________& ___________ - Store working memory (language/sensory associations)
Frontal & Parietal lobes
402
____________________ - emotional memory - Fear in dangerous situation
Amygdala
403
__________/__________ - Store motor skill memory
Basal ganglia / cerebellum
404
Emotional perception and response - mostly in limbic system structures & many of which also process/store memory - __________ : associates memory with emotional importance - __________ : associate sensory stimuli with memories - __________ : response to/affects homeostatic/endocrine/autonomic nervous responses to emotion (heart rate changes, temperature, blushing, adrenaline secretion) - __________ : neurological source of judgment & anticipation of consequences & tempers emotional responses
Amygdala Hippocampus Hypothalamus Prefrontal cortex
405
Stress - physiological / psychological (or both) - similar nervous & endocrine responses to both —-> stimulation of sympathetic nervous system - __________ : processes emotion - __________ : adjusts homeostasis (affects pituitary/adrenal function) - __________ : problem-solving and planning - __________ : mood regulation
Amygdala Hypothalamus Prefrontal cortex Pons
406
____________________ - fail to distinguish reality for unreal perceptions - delusion, hallucination, lack of emotion, impaired ability to communicate/form relationships - linked to limbic system Dopamine overproduction (serotonin/glutamate possibly linked)
Schizophrenia
407
____________________ - mood disorder, low motivation, hopelessness, or sadness, low, self-esteem, irritability, fatigue, self-destructive behavior - may be related to low activity of endorphins, serotonin, dopamine, & norepinephrine
Clinical depression
408
____________________ - Progressive incurable dementia - Onset : short term, memory loss & neural plaques/tangles in brain - Later : confusion & long term memory loss & social withdrawal
Alzheimer’s
409
____________________ - degenerative disease of CNS - Onset : dopamine producing so decline in midbrain substantia nigra & causes muscle control loss & slow movement (shaking) - Later : followed by dementia, depression, other neurological problems, and accumulation of æ-synuclein protein in neurons
Parkinson’s
410
____________________ - Chemical communication via blood - Exerts control at cell, tissue, & organ level - work together with nervous system to maintain homeostasis - Positive feedback loops - Negative feedback loops
Endocrine system
411
Endocrine glands or tissues secrete hormones by __________ & __________ directly into the bloodstream
Diffusion Exocytosis
412
_____________ effects - stimulate or inhibit growth - Control reproductive cycle (development in puberty, pregnancy, birth, & menopause) - induce apoptosis - Regulate metabolism - Maintain homeostasis - Regulate immune physiological response to emergencies, stress, & arousal
Hormone effects
413
Production of ________________ - regulated by blood concentration of ions, nutrients, water, & pH (homeostasis) - Nervous system signals (sensory & emotional control) - Environment (light & temperature) - Other hormones (developmental & positive or negative feedback)
Production of hormones
414
2 types of hormones : ____________ & ____________
Amino acid based (water soluble) Steroid (lipid soluble)
415
____________________ - Single modified amino acids (serotonin, melatonin, histamine, epinephrine, & thyroxine) - Short polypeptides (ADH, calcitonin, & TRH) - Larger proteins (insulin, glucagon, & LH) -Most are hydrophilic & transported dissolved in plasma - Bind to surface proteins - Most initiate a biochemical pathway that triggers intended cellular or molecular changes
Amino acid-based hormones
416
____________________ - sex hormones & adrenocorticoids - Hydrophobic lipid derivatives that are transported in blood, bound to specific globulin proteins - Lipid chemistry allows them to diffuse through the membrane into cell & nucleus (interact with receptors & act directly on gene expression)
Steroid hormones
417
____________________ - causes release of TSH
Thyrotropin releasing hormone (TRH)
418
____________________ - causes release of GH
Growth hormone releasing hormone (GHRH)
419
____________________ - causes release of FSH & LH
Gonadotropin releasing hormone (GnRH)
420
____________________ - causes release of ACTH
Corticotropin releasing hormone (CRH)
421
4 hormones of the Hypothalamus are ____________ ____________ ____________ ____________
TRH GHRH GnRH CRH
422
____________________ - causes release of T3 & T4
Thyroid stimulating hormone (TSH)
423
____________________ - causes release of corticosteroids
Adrenocorticotropic hormone (ACTH)
424
4 hormones of the Anterior Pituitary are ____________ ____________ ____________ ____________
TSH ACTH FSH LH
425
____________________ - hormones synthesized in Hypothalamus, but secreted from here
Posterior pituitary
426
2 hormones of the Posterior Pituitary are ____________ ____________
ADH GH
427
2 hormones of the Thyroid are ____________ ____________
T3 T4
428
The hormone secreted by the Parathyroid is the ____________
PTH
429
The hormone secreted by the Duodenum is the ____________
CCK
430
____________________ - integrates CNS/endocrine function - part of brain composed of nerve tissue - autonomic sensory info (temperature, blood, osmolarity) - affects appetite, thirst, sex drive, & emotions - neurosecretory cells produce peptide hormone-releasing factors (TRH, GHRH, GnRH, & CRH) via hypophyseal portal capillaries directly to the Anterior Pituitary - neurons to the Posterior Pituitary trigger release of ADH & Oxytocin
Hypothalamus
431
____________________ - under Hypothalamic neuroendocrine control - 2 lobes
Pituitary gland
432
_______ to kidneys to reabsorb water if blood osmolarity is high
ADH
433
__________ affects smooth muscle contraction (birth & lactation)
Oxytocin
434
__________ hormones stimulate other glands
Tropic
435
____________________ - hormone that stimulates the adrenal cortex to release androgens & corticosteroids
ACTH
436
____________________ - hormone that stimulates the Thyroid to release T3 & T4
TSH
437
____________________ - hormone that stimulates the maturation of ovarian follicle (female) or maturation of sperm (male)
FSH
438
____________________ - hormone that stimulates ovulation & corpus luteum formation (female) or testosterone production (male)
LH
439
____________________ - direct acting hormone - cell growth —-> liver produce growth factors—-> bone growth
GH
440
____________________ - milk production
Prolactin
441
____________________ - 2 lobes around trachea below larynx - produces 3 hormones
Thyroid
442
__________& __________ - amino acid derivatives of Tyrosine (contains iodine) - regulate basal metabolic rates - increase rates of protein synthesis - in children stimulate growth & nervous system development
T3 & T4
443
Which is more active, T3 or T4 ?
T3
444
____________________ - lowers blood Ca2+ concentration & increases deposition of calcium by osteoblasts - decreases Ca2+ absorption by intestine - decreases kidney reuptake of Ca2+
Calcitonin
445
____________________ - 4 small glands in dorsal surface of thyroid - produce PTH
Parathyroid
446
____________________ - causes blood Ca2+ to increase - activated by Vitamin D - enhances kidney reabsorption of Ca2+ - enhances intestinal absorption - increases osteoclasts activity (dissolve bone to raise blood Ca2+)
PTH
447
Calcitonin & PTH exemplify _____________ hormones
antagonistic
448
____________________ - endocrine & exocrine functions - produce testosterone, responsible for sexual differentiation in embryonic development - LH increases —-> testosterone production increases. —-> development of primary & secondary sex characteristics (body hair, increase muscle mass, & bone density)
Testes
449
_____________________ - produce estrogen & progesterone in response to increased LH
Ovaries
450
_____________________ - induce development of female secondary sex characteristics, the reproductive tract, & ovulation - increase bone density, fat deposition, muscle mass, & blood clotting - affects cholesterol, osmoregulation, thyroid function, & emotions
Estrogens
451
_____________________ - causes endometrium buildup before ovulation or pregnancy - suppresses lactation in pregnancy - reduces immune function (prevents miscarriage) - inhibits labor - strengthens myelin, collagen, skin, bone, teeth, ligaments, & thyroid function
Progesterone
452
After ovulation progesterone is produced by _______________
Corpus luteum
453
______________________ - above kidneys - affect fight or flight response - function of the sympathetic nervous system, metabolism, homeostasis, & development
Adrenal glands
454
______________________ - secretes corticosteroids - mineralocorticoids (aldosterone) : water, Na+, & Cl- retention - glucocorticoids (cortisol) : increase gluconeogenesis, blood sugar, & cell permeability - gonadocorticoids (DHEA& estradiol) : sex development
Adrenal cortex
455
______________________ - secretes catecholamines - Epinephrine/norepinephrine (adrenaline/noradrenaline) : fight or fight response —> constrict blood flow in organs/skin, & vasodilate flow to skeletal muscles, brain, & heart
Adrenal medulla
456
______________________ - islets of Langerhans secrete insulin —-> - causes glucose uptake from blood, increases cellular respiration, & promotes protein synthesis - glucagon is antagonist —-> - response to low blood sugar causes liver glycogen hydrolysis & promotes gluconeogenesis from protein/fat - somatostatin —-> inhibits insulin and glucagon
Pancreas
457
______________________ - secreted by pineal gland - Affects sleep & circadian rhythm
Melatonin
458
______________________ - secreted by heart cells in atria when blood pressure or volume is high - Antagonist to aldosterone - Reduces water, Na+ , and fat in blood
Atrial natriuretic peptide (ANP)
459
_______________ hormones - mostly hydrophilic - variable/cyclical in short term - Cannot diffuse through plasma membranes - Synthesized in rough ER —-> - Transported to Golgi bodies —-> - Packaged in vacuoles —-> - Secreted by exocytosis —-> - Transported in blood to receptors on target cells - (insulin, epinephrine, melatonin, CCK)
Peptide hormones
460
_______________ hormones - hydrophobic (some amino acid hormones) - exit directly through membrane - Mostly insoluble in blood plasma - Carried by hormonal specific globulin proteins in equilibrium with <1% of hormone free in the bloodstream
Steroid hormones
461
__________ hormone molecules can diffuse from capillaries into target cells (as they diffuse into cells, more bound hormones becomes free, maintaining constant blood concentration)
Free
462
Developmental or baseline metabolic hormones include _____ hormones, ____________, _____, & _____
Sex hormones Corticosteroids T3 T4
463
Hormones bind to receptor proteins & initiate a cellular response, where surface receptors are for __________ hormones & intracellular receptors for __________ hormones
Hydrophilic Hydrophobic
464
True or false Some receptors are hormone specific, others respond to several Some cells have multiple receptors that bind to a single hormone
True
465
__________ hormones bind own receptors, disrupt antagonist/receptor binding
Antagonistic hormones
466
Hormone/receptor binding triggers certain _________________ pathways - Phosphorylates or dephosphorylates certain molecules - opens or closes channel proteins - Starts Cascades that increased concentration of second messengers (cAMP) - Activates intracellular communication mechanisms
Signal transduction pathways
467
_______________ - hormone/receptor complex is transported into a nucleus - Interacts with specific gene promoter, inhibitor DNA sequences, or associated proteins - Amplifies or suppresses expression of specific genes
Hydrophobic hormones
468
_______________ - Key role in maintaining stable, optimal internal conditions - Body temperature, blood solute concentration, & blood pressure
Homeostasis
469
_______________ feedback control - the products of hormone function trigger inhibition of production or activity of the hormone - hormone function —> products —> inhibition of hormone function
Negative feedback control
470
_______________ - hormones with opposing affects - Ex : calcitonin (decrease blood Ca2+) & PTH (increase blood Ca2+)
Antagonistic hormones
471
True or false Homeostatic control is often more complex EX : blood sugar balance is affected by insulin, glucagon, somatostatin, Gastrin, epinephrine, norepinephrine, ACTH, and glucocorticoids
True
472
_______________ diseases - over or under production of hormones due to diet, environment, tumors, lesions, or genetic problems - Linked to production of hormones, receptor proteins, or feedback mechanisms
Endocrine diseases
473
_______________ - most common endocrine disorder - Disrupted function of insulin in response to elevated blood sugar - Alters glucose metabolism - Sugar builds up in blood —> kidneys filter excess sugar —> water imbalance as urine becomes hypertonic —> excessive urination, thirst, fatigue, headaches, & blurred vision - Unchecked causes : acute ketoacidosis (ketone bodies), heart, disease, blood pressure, circulatory problems, kidney damage, & stroke - Type 1 : insulin deficiency - Type 2 : insulin receptor or uptake problems
Diabetes mellitus
474
_______________ - secreted by duodenum when chime exits stomach - Triggers the release of pancreatic enzymes & bile - Similar is Gastrin from stomach parietal cells
Cck
475
_______________ - secreted by adipose cells - Decreases appetite & increases metabolism
Leptin
476
_______________ - secreted by seminal vesicles/other tissues - Vasodilation, bronchoconstriction, & smooth muscle control
Prostaglandins
476
_______________ - secreted by seminal vesicles/other tissues - Vasodilation, bronchoconstriction, & smooth muscle control
Prostaglandins
477
_______________ - secreted by liver - Vasoconstriction - Causes aldosterone released by the adrenal cortex
Angiotensin
478
_______________ - secreted by kidney - Stimulates angiotensin production
Renin
479
_______________ - secreted by kidney - A growth factor that stimulates erythrocyte production
Erythropoietin (EPO)
480
____________ receives autonomic sensory homeostatic information - Respond with neurons at end in the posterior pituitary or with hormone secretion to hypophyseal portal capillaries
Hypothalamus
481
_______________ - develops from embryonic nerve tissue - Fight or flight secretions excite sympathetic/inhibit parasympathetic function - Act as neurotransmitters & as hormones on other target organs
Adrenal medulla
482
_______________ - response to nursing - Sensory cells and nipple signal Hypothalamus to release oxytocin from posterior pituitary - Milk released by mammary glands
Lactation
483
_______________ responses - hormones can affect stress, fear, aggression, arousal, & hunger
Emotional
484
True or false Hormones influence behavior but behavior affects hormone levels (correlation between hormones & behavior/emotion)
True
485
Increased _______________ —> increases aggression, sexual arousal, & antisocial behavior
Testosterone
486
_______________ - diurnal shifts in melatonin - Menstrual cycle - Pregnancy - Postpartum - Menopausal changes
Normal hormone fluctuations
487
True or false Abnormal hormone levels affect behavior
True
488
True or false The triggering of behavior directly by the nervous system without mediation of hormones is much faster than hormone mediated behavior
True
489
____________ extend from olfactory bulb into sinuses
Olfactory dendrites
490
_______________ - throat - connects sinuses, mouth, auditory tubes, trachea, & esophagus
Pharynx
491
_______________ - A flap blocking glottis when swallowing
Epiglottis
492
_______________ - rings of cartilage (don’t have back part) - connects pharynx to lungs - lined with cilia (push mucus + particles up to the pharynx & sinuses)
Trachea
493
_______________ - top of trachea - Contains vocal cords
Larynx
494
_______________ - spongy, elastic, high surface area organs - Gas exchange between air & blood
Lungs
495
_______________ - branch from trachea to bronchioles, and lead to alveoli - lined with cilia
Bronchi
496
_______________ - clusters of expandable air sacs around bronchioles - Surrounded by capillaries
Alveoli
497
_______________ - muscle separating abdominal & thoracic cavity - Causes breathing
Diaphragm
498
_______________ - primary respiratory function - Pulmonary capillaries surround alveoli - Diffusion occurs between alveolar air gases & gases dissolved in blood
Gas exchange
499
_______________ - lower partial pressure than inhaled air —> - O2 diffuses into blood —> - RBC Hemoglobin binds up O2 —> - Lowers O2 partial pressure so more diffuses in
Pulmonary blood O2
500
_______________ - higher partial pressure than air —> - CO2 diffuses into alveoli
Pulmonary blood CO2
501
_______________ - In non-sweating animals, evaporative cooling occurs via water vapor loss from respiratory system
Thermoregulation
502
Physical barriers to infection are an __________ immune response to infection (mucous membranes trap particles)
Innate
503
_______________ - found in the lungs, bronchi, trachea, and sinuses - Bring particles to pharynx to be eliminated
Cilia
504
_______________ - antibody from mucous cells - binds/inactivates pathogens - Adaptive immunity
IgA
505
Gas exchange happens in the lungs through the diffusion between ____________ & ____________
Alveoli Capillaries
506
Lungs: (Huge or small) surface area (Thick or thin) membrane between alveoli (rapid or slow) diffusion in capillaries
Huge Thin Rapid
507
Alveolar cells secrete _____________ which prevents collapse & lowers water surface tension (facilitating diffusion)
Surfactant
508
Diffusion of O2 follows concentration gradient into the bloodstream - Inhaled alveolar air - Diffusion across surfactant layer - Diffusion across alveolar epithelial layers, & adjacent capillary endothelium - diffusion/dissolution into blood plasma - Diffusion into RBCs & cooperative binding of __#__ O2 molecules to the iron atoms in __#__ heme moieties of hemoglobin
4 4
509
_______________ - striated muscle that is posterior to lungs & anterior to liver - controlled by the phrenic nerve - Voluntary signal originates in Cerebral Cortex - Involuntary signal originates in Medulla Oblongata - intercostal muscles between ribs help
Diaphragm
510
Muscle contraction & relaxation of the _____________ cause change in lung volume, change in pressure gradient, & causes breathing
Diaphragm
511
Lung inhalation is caused by a ____________ diaphragm - Flattens & increases thoracic cavity volume which generates negative pulmonary air pressure (draws air into lungs to fill volume)
Contracted
512
Lung exhalation is caused by a ____________ diaphragm - Dome shaped & reduces volume of thoracic cavity which allows elastic resiliency of lungs & intercostal muscles to squeeze air out
Relaxed
513
_______________ - volume of air into and out of the lungs with each normal involuntary breath
Tidal volume Vt
514
The lung is surrounded by 2 membranous __________ with a fluid filled cavity in between
Pleura
515
Intrapleural pressure is (higher or lower) than the alveolar pressure?
Lower
516
_________________ = alveolar lung pressure - intrapleural pressure (always >0 which keeps lungs inflated)
Transpulmonary pressure Ptp
517
Alveolar lung pressure is equal to ________________ pressure
Atmospheric Alveolar lung pressure (Ppul)
518
True or false The pleural cavity of each lung is separate
True
519
_______________ - if one of the pleura is perforated in the lungs - P tp = 0 - The lung will collapse
Pneumothorax
520
_______________ - reserve volume - Even when exhaling forcibly (there always remains about 2 L of air)
Residual air
521
_______________ - Low surface tension inside of alveoli prevents lung tissue from adhering which allows for re-inflation against the collapsing force of resiliency
Surfactant
522
_______________ Law - diffusion & solubility of gas in liquid is proportional to partial pressure of that gas in air adjacent to the liquid - explains normal exchange of gases between blood - alveoli - also explains “ the bends” and deep diving
Henry’s law
523
____________________ - O2 bound to hemoglobin heme groups in RBCs - Transports O2 from lungs - sigmoid curve of pO2 effect on the hemoglobin oxygenation shows cooperativity at low O2 (exponential increase) - leveling effect of saturation of hemoglobin at high O2
Oxyhemoglobin
524
Oxygen released by hemoglobin, increases with ____________ , ____________ , & _____________
Increased CO2 (cause decreased pH - “ the Bohr effect”) DPG (product of glycolysis, which is elevated with energy demand) Temperature (associated with energy demand & exercise)
525
____________________ - catalyzes CO2 to HCO3- for blood transport from tissues to lungs
Carbonic anhydrase
526
Rate of ____________ - involuntary control by medulla oblongata neurons send signals through phrenic nerve to diaphragm - voluntarily influenced by cerebral motor cortex
Ventilation
527
Acid chemoreceptors in _______/__________ can override voluntary control of rate of ventilation
Aorta/Hypothalamus
528
If blood pCO2 concentrations increase the pH decreases & the detection by acid-sensitive chemoreceptors forces the ____________ to trigger inhalation
Medulla (hyperventilation—> drop in blood CO2—> medulla slows breathing rate)
529
_______________ Nervous System causes bronchodilation which opens airways & allows more air exchange
Sympathetic
530
_______________ Nervous System causes bronchoconstriction which limits air exchange (immune response to perceived harmful substances, such as allergens or toxins)
Parasympathetic nervous system
531
____________________ - Muscle that pressurizes blood for efficient flow to tissues for exchange & renal filtration
Heart
532
Blood vessels that carry blood towards the heart are ____________
Veins
533
Blood vessels that carry blood away from the heart are ____________
Arteries
534
_______________ circulation - pulmonary arteries take deoxygenated blood from heart to lungs - Branch to alveolar capillaries - Returns oxygenated blood to the heart via pulmonary veins
Pulmonary circulation
535
________________ circulation - Circuit of arteries from left side of heart - Capillaries and tissues throughout the body - Then to the veins - Returns deoxygenated blood to right side heart
Systemic circulation
536
____________________ - A tissue that is predominantly liquid - Carries, dissolved, nutrients, wastes, & biochemical secretions throughout the body - The cells serve many functions such as transport (O2/CO2), protection (immune), & repair (damaged tissues or organs)
Blood
537
Circulatory cells include ____________ , ____________ , & ____________
Erythrocytes Leukocytes Platelets
538
Nutrients are absorbed from intestines & transported first to the _________, then circulated throughout the body
Liver
539
The circulatory systems internal biochemicals include __________ & __________ which are secreted from source cells/glands to target tissues
Hormones Antibodies
540
The circulatory system transports metabolic wastes such as urea, excess minerals, & water to the __________ where it is filtered and excreted
Kidneys
541
Superficial blood vessels dilate to get rid of excess __________ & constrict to conserve
Heat
542
The heart is CNS controlled by the _______________ (modified by sympathetic & parasympathetic systems)
Medulla oblongata
543
The SA node is found in the ______________ wall
Right atrium
544
Heart neuromuscular tissue ask as pacemaker and causes atria to contract —> send signal to AV node/bundle of His/Purkinje fibers which ________ ventricular contraction until ventricles are full
Delay
545
____________________ - exerted by blood on arterial walls - Maximum (systolic) to minimum (diastolic) - 120/80 is normal - 140/90 is hypertension
Blood pressure
546
Blood flows from arteries to arterioles to capillaries & blood pressure (drops or rises) due to blood viscosity & friction from increased surface area of capillary walls
Drops
547
True or false In the capillaries the drop in velocity facilitates efficient nutrient, gas, & waste exchange
True
548
Blood pressure can be affected by ________________ ________________ ________________ ________________ ________________ ________________
Action of venous valves Gravity against vertical flow Muscle movement/breathing Vasoconstriction or dilation Blood volume Blood viscosity
549
____________________ - High pressure in arteries & renal arterioles - Low pressure in large veins & atria - trigger negative feedback barrow reflex in medulla (maintain constant BP) - affect Renin & Angiotensin secretion by kidney - Raises BP by vasoconstriction in response to low blood volume or high osmolarity
Blood pressure regulation
550
________________________ blood vessels form loops between heart & lungs and other tissues
Closed circulating system
551
________________________ thick walled muscular vessels that carry high pressure blood away from heart & blood pressure drops as system branches
Arterial circulation
552
________________________ - thin porous walls (microscopically narrow) in which RBCs line up singly to pass through - form link between arterioles and venules (except for portal systems) - single endothelium layer
Capillary beds
553
________________________ - thin & not muscular - low pressure - skeletal muscle activity aids in flow - presence of valves
Venous circulation
554
________________________ - arterioles lead to 2 capillary beds in sequence rather than directly from capillaries to venules
Portal systems
555
________________________ - due to thin capillary walls, hydrostatic pressure, osmotic pressure, & vasodilation
Capillary permeability
556
___________________ portal system - capillary bed from hypothalamus to anterior pituitary
Hypophyseal portal system
557
_________________ portal system - capillaries in the /small intestine villi carry blood via portal vein to liver capillaries - enzymes remove toxins & regulate blood sugar
Hepatic portal system
558
_________________ portal system - in each nephron - blood filters via glomerular capillaries into Bowman's capsule then blood flows to capillary vasa recta where nutrients, water, & ions are reabsorbed back from convoluted tubule and loop of Henle
Renal portal system
559
Blood -> _____% plasma & _____% 45% cellular components
55% plasma 45% cellular components
560
_______________ - water, ions, gases, nutrients, hormones, proteins (albumin, immunoglobulins, fibrinogen, bilirubin), & wastes
Plasma
561
_______________ - produced from hematopoietic stem cells in bone marrow (fetal spleens) - mature lack nucleus & mitochondria - biconcave disks (high surface area) - filled with hemoglobin - live ~ 3 months
RBCs
562
_______________ - produced by bone marrow hematopoietic cells - immune system cells (Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils)
WBCs
563
_______________ - fragments of megakaryocytes - help in clotting along with proteins (fibrin & collagen)
Platelets
564
_______________ - open circulatory system of vessels, organs, & tissues - primary repository for immune system targeted function - contains most of the WBCs
Lymphatic system
565
_______________ - production of immune cells (macrophages, dendritic, T cells & B cells)
Bone Marrow
566
_______________ - T cell maturation site - secretes hormone Thymosin (stimulates immune system development in juveniles)
Thymus
567
_______________ - largest lymphoid tissue organ - stores & activates immune cells
Spleen
568
_______________ - similar function as spleen - dispersed throughout the body & some specifically associated with digestive, respiratory, & integumentary systems
Lymph Nodes
569
_______________ - transport lymph from lymphatic capillaries through vessels to thoracic duct (recycles lymphatic fluid into the blood)
Lymphatic vessels
570
_______________ - lymphatic capillaries in villi of small intestine & around colon
Lacteals
571
Recovery of lost fluid in capillary filtration of blood - ____% of fluid lost through afferent capillaries is recovered by efferent capillaries - ____% remains flowing interstitially
99% 1%
572
_______________ - collected in lymphatic vessels by pressure gradient - muscular activity & valves aid in flow to thoracic duct then to subclavian veins
Interstitial fluid
573
Absorption of __________ - lacteals are responsible for most lipid absorption - transported to bloodstream or deposited in adipose tissue
Lipids
574
_______________ - lymphocyte T and B cell production - T cell maturation
Thymus & bone marrow
575
_______________ - T cell and B cell storage & proliferation - B cell antibody production (cause of infection)
Lymph nodes, spleen, & tonsils
576
Lymphocytes receive antigens of infectious agents from the __________ cells
dendritic cells
577
_______________ - skin & epithelial layer (blocks infections and limit pathogens) - sweat & sebum ( acidic and antimicrobial) - stomach acid (kills pathogens) - antimicrobial tears (protect cornea)
Physical Barriers
578
Nonspecific phagocytes are __________ & __________ (patrol blood & tissues to engulf pathogens or infected cells)
Neutrophils and Macrophages
579
__________ cells cause apoptosis in infected cells
Natural killer cells
580
__________ proteins secreted by infected cells cause cascade of immune responses
Interferon proteins
581
__________ proteins from the Liver stimulate immune responses and attract & enhance phagocytes
Complement proteins
582
__________ cells and _________ cause inflammation which allow phagocytes, immune proteins, and repair cells to enter injured areas
Mast cells and Basophils
583
_______________ - attraction of immune cells to chemicals secreted by infected cells
Chemotaxis
584
_______________ - hypothalamus causes this increase in temperature - inhibits microbial growth and accelerates immune response
Fever
585
_______________ - specific defenses that recognize antigens of pathogens - cells remain after infection to remember pathogens (respond quicker next time)
Adaptive immune system
586
_______________ - newborns have no immunity - milk delivers IgA antibodies but more effective immune system
Passive Immunity
587
Active Immunity has 2 levels -> _____ & _____
Cellular and Humoral
588
_______________ - defense against infection in tissues - antigen-presenting cells (APCs) detect infection then show antigens to T cells which cause the T cells to proliferate and then destroy infected cells (memory T cells remain after infection for the next time)
Cellular active immunity
589
_______________ - bind foreign antigen to antibodies on B cells then secrete antibodies against specific antigen (memory B cells remain after)
Humoral Active Immunity
590
_______________ - phagocytes to bacteria, fungi, and viruses
Neutrophils
591
_______________ - cytotoxic, degrade toxins, attack parasites, and cause inflammation
Eosinophils
592
_______________ - release Histamine in blood - sensitive to parasites or allergen
Basophils
593
_______________ - release histamine in response to injury, complement protein, or IgE from infection or allergen - found in connective tissue near skin and mucous membranes
Mast Cells
594
_______________ - develop into dendritic cells and macrophages
Monocytes
595
_______________ - antigen presenting cells (APCs) - migrate to and reside in different tissues - after activated they travel to lymph nodes and activate T cells
Dendritic Cells
596
_______________ - patrol bloodstream and tissues - phagocytic and antigen presenting
Macrophages
597
_______________ - B cells and T cells - B cells from Bone marrow - T cells from Thymus
Lymphocytes
598
_______________ - APCs present antigens to inactive T cells then T cell clonal selection then proliferation of effector & memory T cells with receptor antibodies specific to the antigen presented
T cell activation
599
4 classes of effector T cells ____________ ____________ ____________ ____________
Cytotoxic T cells Helper T cells Supressor T cells (regulatory T cells) Natural Killer T Cells
600
_______________ - encounters a virus, fungus, or cancer cell with antigens corresponding to its receptor antibodies - binds to and kills pathogen with Perforins (damage membrane) and Granzymes (destroy proteins) - travels blood & lymph
Cytotoxic T cells
601
_______________ - activate T cells and B cells - secrete lymphokines and interleukins
Helper T cells
602
_______________ - use Negative Feedback to turn off cell-mediated immune response after infection has been eliminated to prevent autoimmune responses
Supressor T cells
603
_______________ - combine functions like Helper T cells and Cytotoxic T cells
Natural Killer T cells
604
_______________ - B cells produce antibodies (Immunoglobulins or Ig) - Ig binds to viruses, bacteria, and toxins (inactivate and target them for destruction)
Humoral Immunity
605
_______________ - proteins or polysaccharides on the surface of bacteria, viruses, tissue grafts, allergens - elicit responses
Antigens
606
_______________ - proteins with specific antigen-binding sites - composed of 5 polypeptide chains in a Y shape with variable antigen-binding sites - stimulate complement system
Antibodies
607
5 types of immunoglobulins __________ __________ __________ __________ __________
IgG IgA IgM IgE IgD "GAMED"
608
Immunoglobulins _____ & _____ protect against blood/lymph pathogens and activate complement system
IgM and IgG
609
Immunoglobulin _____ protects against pathogen entry in mucous membranes
IgA
610
Immunoglobulins _____ & _____ act as antigen receptors on B cells
IgD and IgM
611
Immunoglobulin _____ binds to mast cells & basophils to release histamine (inflammation/Allergies)
IgE
612
_______________ - after specific antigen exposure the B cells make antigen-specific antibodies then clone themselves (plasma cells and some memory cells)
B lymphocyte clonal selection
613
_______________ - self cell antigens recognized by immune cells are ignored - no 2 people have the same MHC (except identical twins)
MHC major histocompatibility complex
614
Nonself cells lack matching ______ markers
MHC
615
____________ system functions - intake essential nutrients, food, and water - catabolize complex biochemicals into simple monomers (depolymerization and hydrolysis) - absorption into bloodstream for use throughout body - excretion of indigestible material
Digestive
616
4 steps of digestive system ____________ ____________ ____________ ____________
Ingestion Digestion Absorption Excretion
617
_______________ - breaks down large pieces into smaller ones - increases surface are of food particles for more enzymatic molecule action
Mechanical digestion
618
_______________ - enzymes break down molecules - amylase breaks down starch to maltose - lipase hydrolyzes lipids into fatty acids & glycerol
Chemical digestion (enzymatic)
619
Stomach pH is about ______ pH
2 pH
620
_______________ - folds in flexible stomach wall when empty - allow expansion up to 2 liters
Rugae
621
_______________ - strong muscular rings
sphincters
622
Stomach 4 special cell types ____________ ____________ ____________ ____________
Chief cells (zymogenic) Parietal cells (oxyntic) Mucous cells Enteroendocrine
623
_______________ - secrete pepsinogen which is then activated by HCl to form pepsin (protease)
Chief Cells
624
_______________ - secrete HCl - acidify by pumping protons/Cl- into stomach cavity
Parietal cells
625
_______________ - secrete much mucus to prevent damage to stomach lining by acid and protease enzymes
Mucous cells
626
_______________ - release gastrin and CCK into bloodstream (stimulates secretions of digestive enzymes when stomach receives food - influences feeling hungry
Enteroendocrine cells
627
628
__________ digestive function - secretes bile salts (emulsifies lipids so lipase enzymes can hydrolyze the smaller lipids)
Liver
629
_______________ - Liver stores glycogen
Glycogenesis
630
_______________ - hydrolysis of glycogen
Glycogenolysis
631
_______________ - Liver makes glucose from lipids/amino acids
Gluconeogenesis
632
_______________ -
633
_________ circulating function - disposes dead RBCs - produces blood proteins (albumin & clotting factors) - synthesizes amino acids & stores vitamins - coverts ammonia to urea for excretion - breaks down toxins
Liver
634
Pancreas secretes __________ to neutralize chyme & activate zymogens
NaHCO3 Sodium bicarbonate
635
_______________ - internal small intestine surface covered with finger like projections (each covered with smaller projections) - maximizes digestive & absorptive surface area
Villi & microvilli
636
_______________ - 1st section of small intestine - most digestion occurs here - stomach squeezes chyme through pyloric sphincter then pancreatic enzymes are secreted through ducts
Duodenum
637
_______ & ________ - majority of absorptive area - amino acids, sugars, minerals, & water absorbed directly into mesentery capillaries to hepatic portal vein to liver - epithelial cells absorbed fats (form lipoprotein chylomicrons) then transfer to lymphatic lacteals
Jejunum & Ileum
638
_______________ - cecum, appendix, ascending colon, transverse colon, descending colon, rectum, anus
Large intestine
639
_______________ - outer letter of kidney - where filtration of blood occurs into the nephrons
Renal cortex
640
_______________ - layer of kidney that forms renal pyramids - contains 2nd set of capillaries that recover nutrients & minerals
Renal Medulla
641
_______________ - collects urine before it flows to bladder
Renal pelvis
642
_______________ - functional unit of the kidney - About 1 million per kidney
Nephron
643
_______________ - tight ball of capillaries - receives high pressure blood from afferent arterial - releases remaining blood into efferent arterial to vasa recta
Glomerulus
644
_______________ - spiracle chamber surrounding the glomerulus - sends filtrate to proximal convoluted tubule
Bowmans capsule
645
_______________ - re-absorbs, nutrients, minerals, water into 2nd set of capillaries (vasa recta) - Blood components reabsorbed or wastes removed in 3 sections
Convoluted tubule’s
646
Is the loop of Henle convoluted?
No
647
_______________ - The capillaries surrounding the convoluted, tubule‘s and loop of Henle - flow to renal vein
Vasa recta
648
_______________ - drains filtrate from each nephron into the renal pelvis
Collecting duct
649
_______________ - Ultrafiltrate from pressure of blood entering these permeable capillaries and forced into Bowman’s Capsule
Glomerulus
650
_______________ - filtrate from Bowmans capsule moves through - water, glucose, amino acids, and ions reabsorbed by vasa recta
Proximal convoluted tubule
651
_______________ - extension of the tubule into renal medulla - 1st part reabsorbs water into interstitial fluid - 2nd part is impermeable to water & pumps Na+ into interstitial fluid which helps maintain gradient for absorbing water in 1st part
Loop of Henle
652
_______________ - Endocrine controlled - Active transport recovers filtered Ca2+ & secretes PO4^3- due to PTH - Aldosterone causes Na+ recovery & loss of K+
Distal convoluted tubule
653
_______________ - Nephrons merge into collecting ducts - Adjust permeability to water in response to changes in ADH, ANP, & aldosterone concentrations
Collecting Duct
654
When there is low blood osmolarity, osmosensors cause secretion of ____________ (travels to DCT where Na/K pumps excrete K & reabsorb Na/Cl and water) and cause secretion of ____________ (increases water reabsorption from collecting ducts)
Aldosterone ADH
655
True or false : angiotensin stimulates aldosterone and has similar effects
True
656
Parathyroid hormone increases blood _____________
Ca2+
657
If high blood volume/pressure and low salinity then ____________ raises filtrate volume by preventing Na+ reabsorption
Atrial Natriuretic Hormone (ANH)
658
Baroreceptors for high pressure are found in __________ & __________
Aorta Juxtaglomerular apparatus in kidney
659
Baroreceptors for low pressure are found in __________ & __________
Atria Venae Cavae
660
______ BP caused by low blood volume, vasodilation, or low viscosity causes release of renin by kidney, activates liver to convert angiotensinogen to angiotensin, increases sympathetic nervous system, increases secretion of aldosterone and ADH, and increases vasoconstriction
Low
661
_______ BP reduces renin secretion, reduces ATH & aldosterone secretion, stimulates parasympathetic nervous system, increases vasodilation, and increases ANH secretion by atrial neurosecretory cells
High
662
The __________ main function is to lower the temperature for a sperm development
Scrotum
663
_______________ - coiled inside testes - Site of sperm formation
Seminiferous tubules
664
____________ cells help support developing sperm
Sertoli cells
665
____________ cells secrete testosterone (causes sperm formation and puberty)
Leydig cells
666
_______________ - smooth muscled ducts on surface of testes - Site of sperm maturation & storage
Epididymis
667
_______________ - smooth muscle ducts from testes into abdominal cavity - Merge into ejaculatory duct through prostate gland into urethra inferior to urinary bladder
Vas deferens
668
_______________ - secrete components of semen (alkaline fluid in which sperm are ejaculated with nutrients, enzymes, & prostaglandins)
Seminal vesicles & Bulbourethral/prostate gland
669
_______________ - Common outlet for Reproductive and urinary tract
Urethra
670
_______________ - male genital (copulatory organ) - Paired corpus cavernosae along dorsal side of penis filled with blood causing erection
Penis
671
_______________ - produce ova & hormones regulating development/reproduction
Ovaries
672
_______________ - clusters of cells with oocyte in center - Some follicles stimulated temperature each month - One ovary releases ovum then maturing follicle secretes estradiol then pituitary spike in LH then causes ovulation and ruptured follicle to become corpus luteum then secretes progesterone and estrogen to stimulate endometrial growth
Ovarian follicles
673
_______________ - fimbrae at distal end of uterine tubes guide ovum into oviduct then cilia propel ovum to uterus
Uterine tubes
674
_______________ - muscular elastic organ in which fetus develops - Inner lining (endometrium) thickens each month anticipating implantation then lining shed if no pregnancy occurs
Uterus
675
_______________ - narrow posterior channel from uterus to vagina
Cervix
676
_______________ - mucus channel from vulva to cervix - Receives sperm, passes menstrual fluid, and is birth canal
Vagina
677
Sperm formation Spermatogonia proliferate on margins of seminiferous tubules & at puberty FSH & LH secretion increases by AP _______ triggers, testosterone secretion, then secondary sex characteristics and mitosis of Spermatogonia into primary spermatocytes then which migrate to lumen of tubules, then undergo meiosis 1 then form 1n secondary spermatocytes, then undergo meiosis 2 then form for spermatids per germ cell ______ causes sperm to mature and grow flagella in the epididymis
LH FSH
678
_______________ - secreted by Sertoli cells and testes when sperm count is high - it decreases production of LH and FSH - If there is a low sperm count, then its production stops, which let LH and FSH levels to rise
inhibin
679
_______________ - body and facial hair, lots of scalp hair, enlargement of larynx, deepening of voice, increased height, increased bone in muscle mass, widening of shoulders, increased sweat and oil secretions by skin
Secondary sex characteristics
680
Ovarian reproductive cycle (Average: 28 days) (Range: 21-35 days) _______________ (1-14 day) - FSH causes several follicles to mature then estradiol levels rise then suppress LH (various hormonal signals cause one follicle to develop ovum) _______________ (14 day) - Rising estrogen levels, then LH spike so follicle releases mature ovum, which is swept by cilia down ovarian tube and lives ~ 1 day in fallopian tube, then disintegrates _______________ (14-28 day) - LH spike at ovulation changes follicle to corpus luteum then secretes, progesterone and endometrial buildup and FSH & LH suppression - Absent fertilization causes corpus luteum to dissolve and menstruation begins as endometrium breaks down
Follicular phase Ovulation Luteal phase
681
_______________ (~12 yrs old) - 1st reproductive cycle begins as a Hypothalamic GnRH causes FSH & LH production by anterior pituitary, then increases progesterone/estrogen
Menarche
682
3 phases of uterine reproductive cycle _______________ _______________ _______________
Menses (1-7 day) Proliferative phase (7-14 day) Secretory phase (14-28 day)
683
_______________ - discharge of tissue, mucus, blood from breakdown of endometrial tissue built up in uterus over previous 2 weeks - Indicates no pregnancy
Menses
684
_______________ - FSH causes ovarian follicles to grow, secreting estradiol and estrogen - promote formation of a new endometrial wall in the uterus
Proliferative phase
685
Menses and proliferative phase is coincide with _______________ phase
Ovarian follicular phase
686
_______________ - spike in LH & FSH then increase progesterone at ovulation - Triggers rapid thickening and increased blood flow into uterine endometrium in preparation for implantation of a blastocyst
Secretory phase
687
The secretory phase coincides with the __________ phase in the ovarian cycle
luteal phase
688
After fertilization, the zygote moves through the uterine tube at _______ days
6-7 days
689
_______________ - reaches uterus as blastocyst - Attaches to endometrium and erodes uterine capillaries, then get surrounded by maternal capillaries - Secretes hCG (human chorionic gonadotropin) - Keeps corpus latuem producing estrogen and progesterone - Maintains uterine lining and prevents menstruation or ovulation
Implantation
690
_______________ - part of blastocyst forms Chorion with villi, with maternal/fetal capillaries in uterine wall - Forms placenta, where nutrients/waste exchange between mother & fetus
Placentation
691
Embryonic ___________ forms, umbilical cord from placenta to fetus - >9 weeks placenta, secretes, progesterone/estrogen (other placental hormones are immunosuppressive)
Allantois
692
_______________ - progesterone/estrogen increase until birth - Promote fetal growth, memory development, & prevent labor - After ~ 40 weeks the pituitary releases oxytocin, which causes labor contractions, prostaglandins to soften cervix, and lactation
Parturition
693
________________ - transverse light & dark bands due to sarcomere protein pattern - long striated fibers, multinucleated, bundled to form a muscle
Skeletal muscle (voluntary & striated)
694
________________ - movement of hollow organs - 2 layers (longitudinal - shortening/dilation) (circular - elongation/constriction)
Smooth muscle (involuntary & nonstriated)
695
________________ - branching cells connected via gap junctions/desmosomes that propagate signals rapidly for uniform contraction - uninucleated
Cardiac muscle (involuntary & striated)
696
Sarcolemma is covered with invaginations called ____________ that carries membrane depolarization into the muscle fiber
T tubules
697
________________ - along muscle fiber like wires (thousands of repeating sarcomeres)
Myofibrils
698
________________ - modified ER surrounds each myofibril & adjacent to T tubules - contain Ca2+ needed to convey action potential to sarcomeres
Sarcoplasmic reticulum
699
________________ - arrangement of cytoskeleton proteins - facilitates contraction
Sarcomere
700
________________ - only in heart - single nucleus & each with T tubules - gap junctions & desmosomes form intercalated disks to transmit signal from SA Node to AV Node (arterial cells contract together then ventricular cells contract)
Cardiac muscle cells
701
_______________ - spindle shaped cells, arranged in sheets or layers - I moved with gradual sustained contraction simultaneous movement in all fibers of a muscle
Smooth muscle
702
_______________ - lack sarcomeres, sarcoplasmic reticulum, or T tubules - actin & myosin filaments spiral within the cell - contain calmodulin, triggers contraction when Ca2+ binds to it
Smooth muscle cells
703
Smooth muscle contraction is triggered by ______________ neurons
Autonomic
704
2 key contractile proteins in sarcomeres are __________ (thick filaments) and __________ (thin filaments)
Myosin Actin
705
______ band - where myosin and actin overlap (it stays the same width even if the sarcomere is contracted or not)
A band
706
_____ band - unbound actin filaments (shorten as Actin is pulled by myosin toward the center of sarcomere)
I band
707
______ zone - center of the sarcomere - Contains roots of myosin thick filaments, and the M line (this cross-links myosin in each myofibril)
H zone
708
______ lines - proteins that anchor the entire sarcomere contractile mechanism
Z lines
709
_______________ - AP travels to axon terminals of motor neurons, then release acetylcholine, which binds to ACh receptors on the sarcolemma then the AP travels into T tubules where depolarization reaches sarcoplasmic reticulum causing voltage gated channels to open and release Ca2+ ions into each myofibril
Motor neuron signal reception
710
_______________ - Ca2+ binds to troponins monomers along tropomyosin Molecules surrounding the actin fibers (prevents myosin-actin bonding) then Ca2+-Troponin alters the tropomyosin allosterically so now exposes myosin binding sites on actin which myosin heads form cross bridges that move along actin fibers and pulls attached Z disks on end of each sarcomere closer together (muscle contraction)
Sarcomere contraction
711
_______________ - when the motor nerve signal ends the Ca2+ pumps activate so force Ca2+ back into the sarcoplasmic reticulum - ATP hydrolyzes to ADP and binds to myosin so weakening the myosin-actin bonds - without Ca2+ tropomyosin blocks myosin-actin binding
Muscle relaxation
712
_______________ - Control a particular movement (squatting and rising)
Agonist muscles
713
_______________ - paired with agonist and control opposite motions
Antagonist muscles
714
_______________ - move toward the medial plane
Adductors
715
_______________ - Move away from the medial plane
Abductors
716
_______________ - Closes a joint
Flexor
717
_______________ - opens a joint
Extensor
718
_______________ - white muscle - Type IIa : oxidative & intermediate - Type IIb : glycolytic & strong anaerobic bursts - fatigue quickly & less blood supply, mitochondria, & myoglobin
Fast twitch muscle
719
_______________ - Red muscle - Type I : sustained aerobic activity & less force - Dense, capillaries and more mitochondria & myoglobin
Slow twitch muscle
720
_________ affect contraction by varying stimulus frequency or intensity
Nerves
721
Stimulus __________ affects force of individual muscle fiber contraction. ____________ affects number of fibers contracting at once.
Frequency Intensity
722
_______________ - all or nothing response - single nerve impulse causes a single muscle fiber contraction - may be quick or prolonged (fast or slow) depending on muscle fiber type
Muscle twitch
723
_______________ - entire muscle contraction depends on many fibers contracting - strength of contraction depends on the stimulus frequency - if stimulus repeated before 1st contraction ends then contractions combine (wave summation) - if repeated result is incomplete tetanus & muscle contracts for prolonged period of time but not at full strength - frequent stimulus causes muscle at complete tetanus (max force) but rapidly fatigues
Graded response
724
_______________ - low/moderate movement - abundant blood O2 to mitochondria recycled ATP by aerobic respiration - energy source is blood glucose
Aerobic muscle activity
725
_______________ - intense movement - if ATP demand exceeds O2 supply then muscle cells have 2 alternative systems (phosphocreatine & glycolysis/lactic acid fermentation)
Anaerobic muscle activity
726
_______________ - stored in muscle & rapidly supplies ATP anaerobically by Creatine Kinase which transfers phosphate from Creatine to ADP - reversed when O2 supply rises
Phosphocreatine
727
_______________ - after a few seconds of O2 limited exertion the muscle fibers use glycolysis to generate ATP until O2 rises - To maintain this process NAD+ must be recycled by fermentation, yielding Lactic Acid which can be used as an energy source in the liver, kidneys, and heart - Requires more O2 to oxidize lactic acid (resulting in oxygen debt)
Glycolysis/Lactic Acid Fermentation
728
_______________ - dense, mineralized, living connective tissue - Hydroxyapatite crystals Ca5 (PO4)3(OH) and collagen - innervate & supplied with blood through Haversian and Volkmann’s canals
Bones
729
2 bones types __________ __________
Compact Spongy
730
_______________ - contact points between bones - Some are fixed and others articulate
Joints
731
___________ skeleton - skull, vertebral column, & rib cage
Axial
732
___________ skeleton - limbs, extremities, & pelvis
Appendicular
733
_______________ - points of connection between bones
Joints
734
_______________ - immovable dense, connective tissue
Fibrous joint
735
_______________ - rigid limited movement - Cartilage as support between bones
Cartilaginous joint
736
_______________ - movable, synovial fluid filled cavity inside synovial membrane - Knee, elbow, wrist …
Synovial joint
737
_______________ - bone cells within solid mineral matrix - Rigid support
Compact bone
738
_______________ - structural subunit of compact bone - Central canal with blood vessels & concentric circles called lamellae - Osteocytes occupy space is in lamellar matrix
Osteon
739
_______________ (cancellous) - porous lightweight - in epiphyses of long bones & interior of others
Spongy bone
740
_____________ (arches) - strong light cavities with marrow
Trabecullae
741
Osteoclasts are stimulated by _________ to secrete HCl & proteases to digest old bone (osteolysis)
PTH
742
Osteoblasts are stimulated by __________ to store Ca2+
Calcitonin
743
_______________ - older trapped osteoblasts that are a part of the living bone matrix and secrete growth hormones
Osteocytes
744
_______________ - dense, connective tissue, collagen, lack nerves and blood supply, but nourished by perichondrium membrane
Cartilage
745
_______________ - dense fibrous connective tissue - connects bones to other bones
Ligament
746
_______________ - tough fibrous connective tissue at the origin & terminal of muscles - Cross joints to attach muscle to bone (facilitate or limit movement)
Tendons
747
_______________ - 4-5 layers of different types of epithelial cells - avascular (O2 diffuses from dermis) - Keratinocytes secrete intermediate filaments of tough keratin - New cells by mitosis in lower layers push older cells up, which bind together and fill with hydrophobic glycolipids & keratin and die (forming outer layers) - melanocytes (pigment), Langerhans cells (immune), Merkel cells (light touch)
Epidermis
748
_______________ - thick layer of connective tissue that nourishes epidermis and has a high capillary density - Supports nerves, glands, smooth muscle, and production of hair & nails
Dermis
749
_______________ - mostly adipose cells - fat layer insulates against heat loss
Hypodermis
750
_______________ - muscles attached to each hair follicle
Arrector pili
751
Integumentary exocrine glands are __________ & ____________
Sebaceous Sudoriferous (sweat)
752
_______________ - skin interacts with circulatory system under sympathetic nerves/endocrine control to constrict or dilate dermis capillaries which shunt excess heat to skin or conserve it under Hypodermis insulating fat layer
Thermoregulation by vasodilation/vasoconstriction
753
_______________ - dissipates heat by evaporative cooling
Sweating
754
_______________ - cause hairs to stand up which creates an air boundary layer that prevents heat loss
Arrector pili
755
Sweat has a (minor or major) role excreting salts, urea, & waste metabolites
Minor
756
______ radiation helps in the synthesis of vitamin D (via Ca2+ metabolism)
UVB radiation
757
UV is absorbed by & stimulates further production of _________
Melanin
758
The skin displays immune protection by preventing infection by pathogens via secreting ________________
Anti-bacterial sebum
759
_______________ - there is no single sense of touch - Different types of sensory neuron receptors, detect different types of tactile stimuli - Free nerve endings, Merkel receptors, Hair receptors, Meisner’s corpuscle’s, Pancinian corpuscles, Ruffini’s corpuscles, & Krause’s bulb
Tactile sensory receptors
760
_______________ - detect pain in the epidermidis
Free nerve endings
761
_______________ - Detect light touch or distinguish shapes & textures in the epidermidis
Merkel receptors
762
_______________ - free nerve endings wrapped around hair follicles that detect pressure or movement against hairs
Hair receptors
763
_______________ - detect light touch in upper dermis
Meisner’s corpuscles
764
_______________ - detect deep pressure at the base of the dermis
Pacinian corpuscles
765
_______________ - sense warmth _______________ - detect cold
Ruffini’s corpuscles Krause’s bulbs
766
3 kinds of causes for small scale mutations ____________ ____________ ____________
Substitution Insertion Deletion
767
____________ - mutation where 1 base replaces another - could be a transition (purine for a purine) or transversion (pyrimidine for a pyrimidine)
Substitution
768
A substitution where a purine base replaces a different purine base is called a ____________
Transition
769
A substitution where a purine base replaces a pyrimidine base is called a ____________
Transversion
770
3 kinds of substitution mutations ____________ ____________ ____________
Silent Missense Nonsense
771
____________ - a substitution mutation that does not alter amino acid sequence
Silent mutation
772
____________ - a substitution mutation that does alter amino acid sequence
Missense mutation
773
____________ - A substitution mutation that causes early stop codon - Results in a non-functional protein
Nonsense mutation
774
__________ or _________ - can result in a frameshift mutation and completely altering a protein
Insertion or deletion
775
____________ - jumping genes - can splice new genetic material into different loci in the genome - Altering proteins, creating frameshifts, or altering gene regulation
Transposons
776
____________ - can insert new genetic material into genomes - Act like a transposons
Viruses
777
____________ - induce mutations - UV, ionizing radiation, free radicals, viruses, & transposons
Mutagens
778
____________ - provides a measure of evolutionary time by comparing accumulated DNA mutations or changes in amino acid sequences of proteins among species
Molecular clock
779
____________ - Heritable changes over time in populations
Evolution
780
____________ - due to sexual reproduction, recombination, & mutations
Genetic variation
781
____________ - Exchange of genes among populations - Increases variation within populations and decreases reproductive isolation of populations necessary for speciation
Gene flow
782
____________ - Random divergence in gene pools when populations are isolated
Genetic drift
783
____________ - in small populations, minor changes in allele frequencies have large affects on later generations (founder effect)
Evolutionary bottleneck
784
____________ - fittest individuals in a population with traits that aid survival and reproduction contribute more to gene pools of later generations - May be directional, stabilizing, or disruptive - Occurs at level of jeans, individuals, kin groups, or populations
Natural selection
785
____________ - nonrandom mating - mate choice based on phenotypic characteristics
Sexual selection
786
____________ - crossing of 2 related species - Viability : ability of offspring to reproduce - Leakage : movement of genes among different species (due to hybridization between species or transfer through a viral vector, which causes a horizontal gene transfer in evolution)
Hybridization
787
____________ - The change in traits that increase in organisms fitness Occurs at the level of population or species (not individuals)
Adaptation
788
____________ - The role in organism plays in its ecosystem (habitat, diet, reproductive strategies, migration …) - Successful adaptations make the organism better suited for this
Niche
789
____________ - A group of naturally interbreeding organisms that produce new individuals of the same kind
Species
790
____________ - The development of new species through the evolution of a population of an existing species that is reproductively isolated from the original species
Speciation
791
A persons temperament is influenced in part by genes - Certain alleles of dopamine receptor _____ are associated with risk taking behavior and others with emotional stress resistance
D4