Biological studies Flashcards
Study for technology used to study the brain and neurotransmission
Passamonti et al 2012
Passamonti et al aim
To investigate whether lowering serotonin alters dynamic interplay between PFC and amygdala
Passamonti et al sample
30 healthy volunteers
Passamonti et al method
- 2 conditions - serotonin depletion vs placebo
- Both group consumed drinks but one in serotonin depletion group lacked tryptophan (an amino acid needed to produce serotonin)
- Put through fMRI machine
- Measured brain responses to angry, neutral and sad faces
- Repeated next week
Passamonti et al results
Reduced activity in frontal lobe during low serotonin conditions when viewing angry faces
Passamonti et al conclusion
- If someone threatened and they have low serotonin might not be able to perform top-down control
- Lack of activity in PFC may affect ability to regulate stress response triggered by amygdala and increase emotional reaction
Passamonti et al strengths
- Randomised sample
- Double blind
Passamonti et al limitations
- did showing faces actually activate amygdala?
- serotonin levels weren’t measured so can we be sure that the people in the condition had less serotonin or that the drink had an effect
- Lacked ecological validity
study for localisation of function
Draganski et al 2004
backstory of HM and Milner
- HM had epilepsy and the severe seizures meant he couldn’t lead a normal life - no medication had an effect
- William Scoville removed the hippocampus from HM’s brain as an experimental surgery in hopes to help him
- HM retained long term memory such as events from childhood
- But forgot things he has just learn (short term memory) like names of people he had just met (anterograde amnesia)
- His personality appeared mostly unchanged
- No intellectual impairment
- Couldn’t recall the last year before the operation
- Brenda Milner studied him until he died in 2008
HM and Milner method
- Psychometric testing: IQ testing was given to HM. His results were above average.
- Direct observation of his behaviour
Interviews with both HM and family members - Cognitive testing: memory recall tests as well as learning tasks - such as reverse mirror drawing
- MRI to determine the extent of the damage done to HM’s brain
HM and Milner results
- HM could not acquire new episodic knowledge (memory for events) and he could not acquire new semantic knowledge (general knowledge about the world) - removed brain structures important for the transfer of information from short-term to long-term memory
- able to form a cognitive map of the spatial layout of his house - spatial memory not encoded the same as semantic or episodic memories
- capacity for working memory - able to have normal conversation which requires a minimal level of retention
- Could recall 3 digit numbers 15 minutes later
- procedural memories maintained - knew how to mow a lawn and improved performance of new skills like reverse mirror drawing where he had to acquire new eye-hand coordination
HM and Milner conclusion
- Implicit memory contains several stores - for example, procedural memory, emotional memory, and skills and habits
- Each of these areas is related to different brain areas
HM and Milner strengths
- Long case study - over 50 years = change could be observed over time
method triangulation - several other case studies of patients like HM (eg. Clive Wearing)
- High ecological validity = observed in his natural environment
- high ethical standards of consent, confidentiality, and protection from harm
HM and Milner limitations
- cannot be easily replicated
- do not have a lot of data on HM’s actual cognitive abilities before the accident
- Uncontrolled - was it the epilepsy that had the effect on his capabilities?
- Only one person and might no be the same in other demographics
Draganski et al aim
to see whether learning a new skill (juggling) would affect the brains of participants
Draganski et al sample
- 24 volunteers (ages 20 - 24)
- 21 f, 3 m
- Non-jugglers
Draganski et al method
- MRI scan at the start of the study to serve as base rate for grey matter and brain structure
- 1 of 2 conditions - jugglers and non-jugglers (control)
- in juggling condition taught three-ball juggling
- asked to practise this and notify when mastered
- jugglers 2nd scan
- told not to juggle anymore and scan three months later
Draganski et al results
- VBM used to see if significant differences in neural density (grey matter)
- no significant differences in the grey matter between the two conditions before study
- at end of first part jugglers had significantly larger amount of grey matter in mid-temporal area in both hemispheres - associated with visual memory
- Three months after (many couldn’t juggle anymore) amount of grey matter in these parts decreased
- no change in non-juggling
Draganski et al conclusion
- juggling relies more on visual memory (perception and spatial anticipation of moving objects) rather than procedural memory (would be change in the cerebellum or basal ganglia)
- Shows evidence of neural pruning
Draganski et al strengths
- pre-test/post-test design
- Experimental = cause-and-effect relationship
- Control group
Draganski et al limitations
- very small sample = may not be reliable
- field experiment = IV manipulated in natural conditions = internal validity (participants at home for a lot)
study for neuroplasticity
Draganski et al 2004
Study for Hormones
Zac 2009
study for evolutionary explanations for attraction
Clark and Hatfield 1978
study for neurotransmission
Passamonti et al 2012
Clark and Hatfield aim
Test parental investment theory
Clark and Hatfield sample
- 48 male participants + 48 female
- 5 female + 4 males asking from mildly unattractive to moderately attractive
- All students
- In florida