Biological Response Modifying and Antirheumatic Drugs Flashcards
What are the two Sub classes of BRM drugs? What are their functions?
Hematopoietic drugs: drugs that affect the formation of blood components
Immunomodulating drugs
What is the MoA of Hematopoietic Drugs?
Stimulate other cells to kill cancer
Decrease recovery time of bone marrow after transfusion
allow for higher doses of chemo
decreases the time of chemo induced anemia or neutropenia
What are the Indications of Hematopoietic drugs?
for pts who have experienced damage to bone marrow due to chemotherapy
decrease the time of neutropenia
enhance the ability of mature cells
What are the Contraindications of Hematopoietic drugs?
allergy
uncontrolled hypertension
What are the Adverse effects of hematopoietic drugs?
Fever
Muscle aches
Bone pain
Flushing
List the Hematopoietic drugs you need to know for the exam
Erythropoietic: darbepoetin
CSF: filgrastim
what is the difference between Colony stimulating factor drugs and Erythropoietic drugs?
CSFs primarily stimulate the production of white blood cells (granulocytes, monocytes, and macrophages) to support the immune system.
Erythropoietic drugs focus on stimulating the production of red blood cells to address conditions like anemia.
What are the types Immunomodulating Drugs?
interferons
Monoclonal antibodies
Interleukin receptor agonists and antagonists
Miscellaneous drugs
What are the four part components of cancer therapy?
Surgery
Chemo
radiation
Immunomodulating drugs
What are the Three ways BRM drugs work?
Enhance hematopoietic effect
Enhance/Regulate host’s immune system to defend against the tumor
Inhibit the movement or growth of the tumor
What are the three properties of Interferons?
Antiviral
Antitumor
Immunomodulating
What is the MoA of Interferons?
Enable immune cells to produce enzymes that stop viral replication
can restore the immune systems functions if it is impaired
can inhibit the immune system if needed
What are the Indications of Interferons?
Viral infections
Cancer
Autoimmune disorders
What are the Adverse effects of Interferons?
Flulike symptoms
NVD
dizzy
anorexia
dose limiting causes fatigue
List the Interferons you need to know for the Exam
IFN alfa 2b
Peginterferon alfa 2a
IFN-ß products
What is the MoA of Monoclonal Antibodies
these drugs can specifically target cancer cells and are used for the treatment of cancer
MS
RA
transplantation
What is Tumor Necrosis Factor (TNF)?
is a cytokine used in the systemic inflammation process; is produced by macrophages
What are TNF inhibitors?
Drugs that help stop inflammation
What do TNF inhibitors treat?
RA, juvenile arthritis, Crohn’s disease, (many arthritis’s)
List the Monoclonal Antibodies you need to know for the exam and what they are used to treat
Adalimumab (RA)
Infliximab (RA, Crohn’s)
Rituximab (NHL)
Natalizumab (MS)
What do you have to premedicate pts taking Rituximab with and why?
due to allergic response pt needs to be premedicated with diphenhydramine and acetaminophen
What is the MoA of Interleukins?
IL-2: aids the the growth and development of t cells
What are the indications of Interleukins
Metastatic malignant melanoma
What are the Contraindications of Interleukins?
allergy
organ transplant
abnormal heart stress test
What is Capillary leak syndrome?
is the severe toxicity of aldesleukin therapy. Is when the capillaries loos the ability to retain vital colloids (plasma expanders) in the blood this casues massive fluid retention
What are the Interleukins you need to know for the Exam?
Aldesleukin
What is Rheumatoid Arthritis?
An autoimmune disorder that causes inflammation and damage to tissue and joints
What are the Two types of Drugs that can treat RA?
NSAID
Disease modifying antirheumatic drugs (DMARD)
What is Osteoarthritis?
a type of arthritis that is age related; is not auto immune related
What is the MoA of Disease Modifying Antirheumatic drugs?
exhibit anti-inflammatory, antiarthritic, and immunomodulating effects by inhibiting the movement of cells into inflamed areas
List the Non Biological DMARDs who need to know for the exam
Methotrexate
Leflunomide
What is Methotrexate?
A first Line therapy drug for RA; can be given for cancer in lower doses (7.5-20mg)
List the Non-Biological DMAR drugs you need to know for the exam
Adalimumab
Etanercept
Infliximab
Abatacept
List some Nursing implications of Biological Response Modifying drugs
Asses baseline blood counts
Asses cardiac, kidney and liver function
asses for infection
Asses and monitor for bone pain
Watch for febrile neutropoenia
