Biological Response Modifying and Antirheumatic Drugs

Question 1

What are the two Sub classes of BRM drugs? What are their functions?

Answer 1

Hematopoietic drugs: drugs that affect the formation of blood components
Immunomodulating drugs

Question 2

What is the MoA of Hematopoietic Drugs?

Answer 2

Stimulate other cells to kill cancer
Decrease recovery time of bone marrow after transfusion
allow for higher doses of chemo
decreases the time of chemo induced anemia or neutropenia

Question 3

What are the Indications of Hematopoietic drugs?

Answer 3

for pts who have experienced damage to bone marrow due to chemotherapy
decrease the time of neutropenia
enhance the ability of mature cells

Question 4

What are the Contraindications of Hematopoietic drugs?

Answer 4

allergy
uncontrolled hypertension

Question 5

What are the Adverse effects of hematopoietic drugs?

Answer 5

Fever
Muscle aches
Bone pain
Flushing

Question 6

List the Hematopoietic drugs you need to know for the exam

Answer 6

Erythropoietic: darbepoetin
CSF: filgrastim

Question 7

what is the difference between Colony stimulating factor drugs and Erythropoietic drugs?

Answer 7

CSFs primarily stimulate the production of white blood cells (granulocytes, monocytes, and macrophages) to support the immune system.
Erythropoietic drugs focus on stimulating the production of red blood cells to address conditions like anemia.

Question 8

What are the types Immunomodulating Drugs?

Answer 8

interferons
Monoclonal antibodies
Interleukin receptor agonists and antagonists
Miscellaneous drugs

Question 9

What are the four part components of cancer therapy?

Answer 9

Surgery
Chemo
radiation
Immunomodulating drugs

Question 10

What are the Three ways BRM drugs work?

Answer 10

Enhance hematopoietic effect
Enhance/Regulate host’s immune system to defend against the tumor
Inhibit the movement or growth of the tumor

Question 11

What are the three properties of Interferons?

Answer 11

Antiviral
Antitumor
Immunomodulating

Question 12

What is the MoA of Interferons?

Answer 12

Enable immune cells to produce enzymes that stop viral replication
can restore the immune systems functions if it is impaired
can inhibit the immune system if needed

Question 13

What are the Indications of Interferons?

Answer 13

Viral infections
Cancer
Autoimmune disorders

Question 14

What are the Adverse effects of Interferons?

Answer 14

Flulike symptoms
NVD
dizzy
anorexia
dose limiting causes fatigue

Question 15

List the Interferons you need to know for the Exam

Answer 15

IFN alfa 2b
Peginterferon alfa 2a
IFN-ß products

Question 16

What is the MoA of Monoclonal Antibodies

Answer 16

these drugs can specifically target cancer cells and are used for the treatment of cancer

MS
RA
transplantation

Question 17

What is Tumor Necrosis Factor (TNF)?

Answer 17

is a cytokine used in the systemic inflammation process; is produced by macrophages

Question 18

What are TNF inhibitors?

Answer 18

Drugs that help stop inflammation

Question 19

What do TNF inhibitors treat?

Answer 19

RA, juvenile arthritis, Crohn’s disease, (many arthritis’s)

Question 20

List the Monoclonal Antibodies you need to know for the exam and what they are used to treat

Answer 20

Adalimumab (RA)
Infliximab (RA, Crohn’s)
Rituximab (NHL)
Natalizumab (MS)

Question 21

What do you have to premedicate pts taking Rituximab with and why?

Answer 21

due to allergic response pt needs to be premedicated with diphenhydramine and acetaminophen

Question 22

What is the MoA of Interleukins?

Answer 22

IL-2: aids the the growth and development of t cells

Question 23

What are the indications of Interleukins

Answer 23

Metastatic malignant melanoma

Question 24

What are the Contraindications of Interleukins?

Answer 24

allergy
organ transplant
abnormal heart stress test

Question 25

What is Capillary leak syndrome?

Answer 25

is the severe toxicity of aldesleukin therapy. Is when the capillaries loos the ability to retain vital colloids (plasma expanders) in the blood this casues massive fluid retention

Question 26

What are the Interleukins you need to know for the Exam?

Answer 26

Aldesleukin

Question 27

What is Rheumatoid Arthritis?

Answer 27

An autoimmune disorder that causes inflammation and damage to tissue and joints

Question 28

What are the Two types of Drugs that can treat RA?

Answer 28

NSAID
Disease modifying antirheumatic drugs (DMARD)

Question 29

What is Osteoarthritis?

Answer 29

a type of arthritis that is age related; is not auto immune related

Question 30

What is the MoA of Disease Modifying Antirheumatic drugs?

Answer 30

exhibit anti-inflammatory, antiarthritic, and immunomodulating effects by inhibiting the movement of cells into inflamed areas

Question 31

List the Non Biological DMARDs who need to know for the exam

Answer 31

Methotrexate
Leflunomide

Question 32

What is Methotrexate?

Answer 32

A first Line therapy drug for RA; can be given for cancer in lower doses (7.5-20mg)

Question 33

List the Non-Biological DMAR drugs you need to know for the exam

Answer 33

Adalimumab
Etanercept
Infliximab
Abatacept

Question 34

List some Nursing implications of Biological Response Modifying drugs

Answer 34

Asses baseline blood counts
Asses cardiac, kidney and liver function
asses for infection
Asses and monitor for bone pain
Watch for febrile neutropoenia