Biologic Oxidation Flashcards
Gain of electron
Reduction
The process by which cells derive energy in the form of ATP from controlled reaction of hydrogen with oxygen from water
Respiration
Removal of electron
Oxidation
Redox potential is normally expressed at pH ____, at which pH the electrode potential of the hydrogen electrode is _____
7.0 , -0.42
It allows at prediction of the direction of flow of electron
Redox system
Enzymes involved in oxidation and reduction
Oxidoreductase
It catalyze the removal of hydrogen from a substrate using oxygen as hydrogen acceptor
Oxidases
Oxydases form ___ or ____ as reaction product
Water or hydrogen peroxide
It is a hemeprotein having the typical heme prosthetic group myoglobin and hemoglobin
Cytochrome oxidase
Action of oxydase is blocked by
Carbon monoxide, cyanide, and hydrogen sulfide
Cause of cellular respiration poisoning
Carbon monoxide, cyanide and hydrogen sulfide
Cytochrome oxidase contains ____ molecules of heme, each having one ____ atom, that oscillates between ____ and ____ during oxidation and reduction.
2, Fe, Ferric, Ferous
Types of oxidases
Cytochrome oxidase and flavoprotein
Flavoprotein enzymes contain
Flavin mononucleotide or flavin adenine dinucleotide
FMN and FAD are formed in the body from the vitamin
Riboflavin
Types of flavoprotein that contains one or more metal as essential factor
Metalloflavoproteins
An FMN linked enzyme found in the kidney
L amino acid oxidase
It contains molybdenum and plays an important role in the conversion of purine bases to uric acid
Xanthine oxidase
FAD linked enzyme present in the mammalian liver
Aldehyde dehydrogenase
It contains molybdenum and non heme iron and acts upon aldehydes and N-heterolytic substrates
Aldehyde dehydrogenase
Enzymes used by dehydrogenase
Nicotinamide adenine dinucleotide
Nicotinamide adenine dinucleotide phosphate
The proteins of dehydrogenase are formed in the body from vitamin
Niacin
It catalyze oxidoreduction reaction in the oxidative pathways of metabolism
NAD linked dehydrogenase
It is concerned in the electron transport in the respiratory chain
Riboflavin linked dehydrogenase
Proteins that are tightly bind to their apoenzymes than are the nicotinamide coenzymes
Riboflavin linked dehydrogenase
Acts as a carrier of electron between NADH and the components of higher redox potential
NADH dehydrogenase
Dehydrogenase that transfer reducing equivalent directly from substrate to the respiratory chain
Succinate dehydrogenase
Acyl coa dehydrogenase
Mitochondrial 3 phosphate dehydrogenase
Its is an intermediarry carrier of electron between acyl coa dehydrogenase and the respiratory chain
Electron transferring flavoprotein
Iron containing hemo protein
Cytochromes
In the respiratory chain, they are involved as carrier of electron from flavoprotein and cytochrome oxydase
Cytochrome
They protect the body agains harmful peroxide
Hydroperoxidase
Accumulation of peroxide can lead to generation of free radicals which can…
Disrupt membrane and cause cancer and artherosclerosis
They are found in milk and in leukocytes, playelets and other tissues involved in eicosanoid metabolism
Peroxidase
______ is reduced at the expense of several substance that will act as an electron acceptor
Hydrogen peroxide
It catalyzes the destruction of H2O2 and lipid hydroperoxide
Glutathione peroxidase containing selenium
Heme protein containing 4 heme groups
Catalase
It is found in the blood, bone marrow, mucous membranes kidney and liver
Catalase
It functions to destroy hydrogen peroxide formed by the action of oxidase
Catalase
Rich in oxidase and catalase
Peroxisomes
It is concerned with the synthesis or degradation of many different metabolites
Oxygenase
They catalyze the incorporation of oxygen to the substrate
Oxygenase
