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BIOCHEMISTRY 1 > Bioenergetics > Flashcards

Bioenergetics Flashcards

1
Q

Barbiturates

A

inhibit e- transport via Complex 1 from Fe-S to CoQ

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2
Q

Antimycin A, Dimercapral

A

inhibit respiratory chain at complex 3

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3
Q

H2S, CO, CN-

A

inhibit Complex 4

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4
Q

Malonate

A

competitive inhibitor of Complex 2

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5
Q

Oligomycin

A

inhibits oxidation and phosphorylation by blocking the proton flow through ATP synthase

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6
Q

Atractyloside

A

inhibit oxidative phosphorylation by inhibiting the ADP/ATP transporter

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7
Q

Uncouplers

A
  • dissociate oxidation from phosphorylation in the respiratory chain ⇒ uncontrolled respiration since the rate is no longer limited by ADP or Pi concentration
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8
Q

Cyanide

A

blocks the function of cytochrome C oxidase

inhibit oxidative phosphorylation

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BIOCHEMISTRY 1 (9 decks)

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