Biocompatibility Flashcards
What is the difference between histocompatibility and cytocompatibility?
Histo is dealing with a whole tissue whereas cyto is with the individual cells.
What is In Vitro testing?
In glass, isolated populations of cells.
What is Ex Vivo testing?
Out of living. Whole tissues are extracted from organisms.
What is In Vivo testing?
In the living. Experiments on live organisms, doesn’t have to be in the area of interest.
What is Usage testing?
In Vivo testing using material within its clinical context.
What is the difference between direct and indirect In Vitro testing?
Direct is when cells are placed on the material and indirect is when there is a barrier between the cells and the material.
What is the dentin bridge?
It is the formation of connecting bridge between dentin the underlying pulp.
What is the hybrid layer?
It is the layer formed between the resin composite and dentin, attaching via collagen fibrils. The down side is that enzymes capable of breaking down ECM can also degrade this.
How do bacteria increase MMP function? Why is this bad for restorations?
Bacteria are able to activate MMPs by inhibiting the inhibitors of MMPs. This is bad for restorations because the MMPs are responsible for remodeling the organic matrixes and can break them down near the restorations.
Why are amalgams able to increase there seal with age?
This is done by the corrosion products of the amalgam as time goes on.
What is the reason that adverse reactions in the pulp tissue is not seen with glass ionomers?
The polyacrylic acid used is relatively large and will not diffuse through dentin.
What is the compound frequently used as lining material?
Calcium Hydroxide.
What is the effect of zinc phosphate when in direct contact with pulp? Why is it ok to still use?
Tissue necrosis. It will not diffuse through the dentin.
What is MTA and what is it used for?
Modified portland cement. Used predominantly in pulp capping and is very similar to quikrete. Encourages dentin bridge formation.
Why do bleaching agents lead to so much sensitivity?
They contain peroxide which is able to rapidly traverse enamel and dentin and come into contact with pulp.
