Biochem32 Flashcards
Lipid transport Apolipoproteins
Function of Pancreatic lipase.
Degrade dietary TG in Small Intestines
Function of Lipoprotein lipase (LPL)
Degrades TG circulating in chylomicrons and VLDLs
Function of Hepatic TG lipase (HL)
Degrades TG remaining in IDL
Function of Hormone-sensitive lipase.
Degrades TG stored in Adipocytes
What enzyme catalyzes esterification of cholesterol?
Lecithin-cholesterol acyltransferase (LCAT)
What mediates the transfer of cholesterol esters to other lipoproteins?
Cholesterol Ester Transfer Protein (CETP)
What enzyme converts Nascent HDL to Mature HDL?
Lecithin-Cholesterol Acyltransferase (LCAT)
Function of Apolipoprotein E.
Mediates remnant uptake
Function of Apolipoprotein A-I
Activates LCAT
Function of Apolipoprotein C-II
Lipoprotein lipase Cofactor
Function of Apolipoprotein B-48.
Mediates chylomicron secretion
Function of Apolipoprotein B-100
Binds LDL receptors
Apolipoprotein E is NOT involved with what lipoprotein?
LDL
What is the only lipoprotein associated with Apo A-I?
HDL
Apo C-II is involved with what lipoproteins?
Chylomicron, VLDL, HDL
What lipoproteins are involved with Apo B-100?
VLDL
IDL
LDL
What transports cholesterol from the liver to the tissues?
LDL
“LDL is Lousy”
Where does HDL transport cholesterol?
From periphery to liver
“HDL is Healthy”
What secretes chylomicrons?
intestinal epithelial cells
What is the function of chylomicrons?
- Delivers dietary Triglycerides to Peripheral tissues
- Delivers cholesterol to Liver in the form of chylomicron remnants (depleted of triacylglycerols)
What is the function of VLDL?
Delivers Hepatic TGs to peripheral tissues
What is formed in the degradation of VLDL?
IDL
What is the function of IDL?
Delivers Triglycerides and Choelsterol to the liver
How is LDL formed?
hepatic lipase modification of IDL in peripheral tissues
*taken up by target cells via receptor-mediated endocytosis
