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FA - Biochem > Biochem32 > Flashcards

Biochem32 Flashcards

Lipid transport Apolipoproteins

1
Q

Function of Pancreatic lipase.

A

Degrade dietary TG in Small Intestines

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2
Q

Function of Lipoprotein lipase (LPL)

A

Degrades TG circulating in chylomicrons and VLDLs

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3
Q

Function of Hepatic TG lipase (HL)

A

Degrades TG remaining in IDL

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4
Q

Function of Hormone-sensitive lipase.

A

Degrades TG stored in Adipocytes

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5
Q

What enzyme catalyzes esterification of cholesterol?

A

Lecithin-cholesterol acyltransferase (LCAT)

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6
Q

What mediates the transfer of cholesterol esters to other lipoproteins?

A

Cholesterol Ester Transfer Protein (CETP)

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7
Q

What enzyme converts Nascent HDL to Mature HDL?

A

Lecithin-Cholesterol Acyltransferase (LCAT)

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8
Q

Function of Apolipoprotein E.

A

Mediates remnant uptake

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9
Q

Function of Apolipoprotein A-I

A

Activates LCAT

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10
Q

Function of Apolipoprotein C-II

A

Lipoprotein lipase Cofactor

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11
Q

Function of Apolipoprotein B-48.

A

Mediates chylomicron secretion

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12
Q

Function of Apolipoprotein B-100

A

Binds LDL receptors

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13
Q

Apolipoprotein E is NOT involved with what lipoprotein?

A

LDL

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14
Q

What is the only lipoprotein associated with Apo A-I?

A

HDL

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15
Q

Apo C-II is involved with what lipoproteins?

A

Chylomicron, VLDL, HDL

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16
Q

What lipoproteins are involved with Apo B-100?

A

VLDL
IDL
LDL

17
Q

What transports cholesterol from the liver to the tissues?

A

LDL

“LDL is Lousy”

18
Q

Where does HDL transport cholesterol?

A

From periphery to liver

“HDL is Healthy”

19
Q

What secretes chylomicrons?

A

intestinal epithelial cells

20
Q

What is the function of chylomicrons?

A
  • Delivers dietary Triglycerides to Peripheral tissues

- Delivers cholesterol to Liver in the form of chylomicron remnants (depleted of triacylglycerols)

21
Q

What is the function of VLDL?

A

Delivers Hepatic TGs to peripheral tissues

22
Q

What is formed in the degradation of VLDL?

A

IDL

23
Q

What is the function of IDL?

A

Delivers Triglycerides and Choelsterol to the liver

24
Q

How is LDL formed?

A

hepatic lipase modification of IDL in peripheral tissues

*taken up by target cells via receptor-mediated endocytosis

25
Q

Where is HDL secreted from?

A

Liver & Intestine

26
Q

HDL mediates what?

A

reverse cholesterol transport from periphery to liver

27
Q

HDL acts as a repository for what?

A

apoC & apoE

*need for chylomicron & VLDL metabolism

FA - Biochem (17 decks)

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