Biochem3

Question 1

Mutation in the mismatch repair mechanism is seen in what type of cancer?

Answer 1

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

Question 2

The inability to bring together 2 ends of DNA frgaments to repair double-stranded breaks due to a genetic mutation leads to what disease?

Answer 2

Ataxia telangiectasia

Question 3

T/F DNA and RNA are both synthesized 5’ to 3’

Answer 3

True

Question 4

In DNA and RNA synthesis what nucleotide (5’ or 3’) bears the triphosphate (energy source for bond)

Answer 4

5’

Question 5

mRNA is read ?’ to ?’

Answer 5

5’ to 3’

Question 6

Protein synthesis is ?-terminus to ?-terminus.

Answer 6

N-terminus to C-terminus

Question 7

What do drugs blocking DNA replication often have?

Answer 7

Modified 3’ OH, preventing addition of the next nucleotide (“chain termination”)

The triphosphate bond is the target of the 3’ hydroxyl attack

Question 8

DNA synthesis requires what to add the next nucleotide?

Answer 8

free 3’ OH

Question 9

What are the 3 main types of RNA?

• Most abundant
• Longest
• Smallest

Answer 9

rRNA - most abundant
mRNA - longest
tRNA - smallest

“rAMPANT, mASSIVE, tINY”

Question 10

mRNA start codons

Answer 10

AUG (rarely GUG)

“AUG inAUGurates protein synthesis”

Question 11

AUG codes for what in Eukaryotes?

Answer 11

Methoinine, may be removed before translation is completed

Question 12

mRNA stop codons

Answer 12

UGA - U Go Away
UAA - U Are Away
UAG - U Are Gone