BIOCHEM: NUCLEIC ACID Flashcards

1
Q

What are the molecules that is responsible for the storage and transfer of genetic information.

A

Nucleic acids

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2
Q

Who discovered nucleic acids and when?

A

Friedrich Miescher discovered nucleic acids in 1869.

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3
Q

What are the two types of nucleic acids found in higher organisms?

A

The two types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

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4
Q

Where is most DNA found in a cell?

A

within the cell nucleus.

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5
Q

What is the primary function of DNA?

A

storage and transfer of genetic information.

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6
Q

What is the primary function of RNA?

A

synthesis of proteins.

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7
Q

What are nucleotides?

A

Nucleotides are the monomer units that make up nucleic acids.

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8
Q

What is the structural distinction between DNA and RNA?

A

DNA and RNA have different structural properties, which are essential for their functions.

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9
Q

What remarkable property do living cells have?

A

Living cells have the ability to produce exact replicas of themselves.

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10
Q

What is the significance of nucleic acids in cell division?

A

Nucleic acids are passed from existing cells to new cells during cell division.

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11
Q

What are the building blocks of nucleic acids?

A

Nucleic acids are made up of nucleotides.

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12
Q

What are the three subunits of a nucleotide?

A

A nucleotide consists of a pentose sugar, a phosphate group, and a nitrogen-containing heterocyclic base.

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13
Q

How are the atoms in the pentose and nitrogen-containing base subunits of a nucleotide numbered?

A

Pentose ring atoms are designated with primed numbers, and nitrogen-containing base ring atoms are designated with unprimed numbers.

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14
Q

What are the two types of pentose sugars found in nucleotides?

A

The two types of pentose sugars are ribose and 2’-deoxyribose.

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15
Q

What is the structural difference between ribose and 2’-deoxyribose?

A

The only difference is at carbon 2’: ribose has an -OH group, while 2’-deoxyribose has a -H atom.

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16
Q

What does RNA stand for and what sugar does it contain?

A

RNA stands for ribonucleic acid and contains ribose sugar.

17
Q

What does DNA stand for and what sugar does it contain?

A

DNA stands for deoxyribonucleic acid and contains 2’-deoxyribose sugar.

18
Q

What are the five nitrogen-containing heterocyclic bases in nucleotides?

A

The five bases are thymine (T), cytosine (C), uracil (U), and two purine derivatives.

19
Q

What are the three pyrimidine derivatives found in nucleotides?

A

The three pyrimidine derivatives are thymine (T), cytosine (C), and uracil (U).

20
Q

What are the chemical structures of thymine, cytosine, and uracil?

A

Thymine is the 5-methyl-2,4-dioxo derivative, cytosine is the 4-amino-2-oxo derivative, and uracil is the 2,4-dioxo derivative of pyrimidine.

21
Q

What are the two purine bases found in nucleotides?

A

Adenine (A) and Guanine (G)

Remember with the phrase ‘pure silver’ (Ag) for purines.

22
Q

What are the three pyrimidine bases found in nucleotides?

A

Thymine (T), Cytosine (C), and Uracil (U)

23
Q

How many possible RNA nucleotides are there?

A

Four possible RNA nucleotides: A, C, G, or U.

24
Q

How many possible DNA nucleotides are there?

A

Four possible DNA nucleotides: A, C, G, or T.

25
Q

What is the common ending for nucleotide names?

A

All names end in 5’-monophosphate.

26
Q

What suffix is used for purine bases in nucleotide nomenclature?

A

The suffix -osine is used with purine bases.

27
Q

What suffix is used for pyrimidine bases in nucleotide nomenclature?

A

The suffix -idine is used with pyrimidine bases.

28
Q

What does the prefix ‘deoxy-‘ signify in nucleotide names?

A

It signifies that the sugar present is deoxyribose.

29
Q

What sugar is present when no prefix is in the nucleotide name?

A

The sugar present is ribose.

30
Q

What is the nucleotide name for deoxyadenosine?

A

Deoxyadenosine 5’-monophosphate

Abbreviation: dAMP

31
Q

What is the nucleotide name for deoxyguanosine?

A

Deoxyguanosine 5’-monophosphate

Abbreviation: dGMP

32
Q

What is the nucleotide name for deoxycytidine?

A

Deoxycytidine 5’-monophosphate

Abbreviation: dCMP

33
Q

What is the nucleotide name for deoxythymidine?

A

Deoxythymidine 5’-monophosphate

Abbreviation: dTMP

34
Q

What is the nucleotide name for adenosine?

A

Adenosine 5’-monophosphate

Abbreviation: AMP

35
Q

What is the nucleotide name for guanosine?

A

Guanosine 5’-monophosphate

Abbreviation: GMP

36
Q

What is the nucleotide name for cytidine?

A

Cytidine 5’-monophosphate

Abbreviation: CMP

37
Q

What is the nucleotide name for uridine?

A

Uridine 5’-monophosphate

Abbreviation: UMP