Biochem Finals Pt.1 Flashcards
CHO
Carbohydrates / Lipids
CHON
Proteins
CHONSP
Nucleic acids
A semi-permeable layer of the cell; allowing the selective entry and exit of substances
Cell Membrane
Humans differ from plants in a way that humans have cell membrane but plants have both cell membrane and cell wall
The powerhouse of the cell; known to generate energy in the form of ATP
Mitochondrion
The type of endoplasmic reticulum where the ribosomes are attached
Rough ER
Where lipid synthesis usually happens
Smooth ER
Where protein synthesis usually happens
Rough ER
Has enzymes that are capable of digesting foreign cells (apoptosis of microbial cells)
- immunity
- known as the suicide bag of the cell
Lysosomes
Involved in protein synthesis
Ribosomes
Proteins are important in maintaining homeostasis in the body. They are responsible for the different enzymes in the body. Enzymes have different functions which are important to sustain life.
Humans ribosomal units
80s (40s and 60s)
responsible for package and storage of different substances inside the cell
Golgi apparatus
Plants specialized structure for storage
Vacuoles
Microorganisms specialized structure for storage
Inclusions
The control center of the cell; it houses the chromosomes where DNA is coiled.
Nucleus
Additional protective barrier of the nucleus to protect the DNA
Nuclear membrane/envelope
1 sugar unit
- identified by the number of carbons
Monosaccharides/Sugar
- Blood sugar, Physiologic sugar, Dextrose, Grape sugar
Glucose
- Levulose, Fruit sugar
- the sweetest sugar
Fructose
It is readily absorbed in the intestine
Galactose
Increased levels of galactose in the blood
Galactosemia
Sugar found in the RNA
Ribose
Sugar found in the DNA
Deoxyribose
- Wood sugar; important diagnostic agent for intestinal malabsorption
Xylose
2 sugar units
Disaccharides
Glucose + Fructose
Sucrose
Glucose + Glucose
Maltose
Glucose + Galactose
- present in milk and other dairy products
Lactose
3 sugar units
Trisaccharides
Glu + Glu + Glu
Maltotriose
Glu + Gal + Fru
Raffinose
Glu + Glu + Fru
Gentianose
Binder, Disintegrant, or Filler in tablets
Starch
Storage form of glucose in mammals
Glycogen
- Component of plant cell wall
- Indigestible
Cellulose
Component of fungi cell wall
Chitin
Used to diagnose renal function
Inulin
An important anti-coagulant drug
Heparin
A carbohydrate that lubricates joints and acts as a cushion for joints
Hyaluronic acid
Once hydrolyzed, they arrive with sugar or glucose units
Homoglycans
Once hydrolyzed, will not produce glucose units only
Heteroglycans
Examples of homoglycan polysaccharides
Starch
Glycogen
Cellulose
Chitin
Examples of heteroglycan polysaccharides
Inulin
Heparin
Hyaluronic acid
Dextro - Right
Levo - Left
Carbon with different attachments
Chiral
Term used in the second to the last carbon
- It dictates the rotation
Penultimate carbon
Structures with the same composition but different arrangements
Isomers
Two structures are mirror images of each other
Enantiomers
Structures that are non-mirrored
Diastereomers
- break down
- energy producing
- “lysis”
Catabolism
- build up
- energy requiring
- genesis
Anabolism
combination of anabolic and catabolic
- krebs cycle
Amphibolism
It is the sum of all chemical reactions in the body
Metabolism
- Breakdown of glucose
- Glucose to Pyruvate
Glycolysis
Products of Glycolysis
2 NADH, 2 Pyruvate, 2 ATPS
- Formation of glucose from a noncarbohydrate source
- Lactate, Pyruvate, Fats to Glucose
- Liver
Gluconeogenesis
Product of Gluconeogenesis
Glucose
It is a product of anaerobic reaction (in the muscles) in the body
- responsible for pain and fatigue
Lactate
From lactate to glucose to lactate
Cori’s Cycle
- Formation of Glycogen
- Glucose to Glycogen
Glycogenesis
Product of Glycogenesis
Glycogen
- Breakdown of glycogen
- Glycogen to Glucose
Glycogenolysis
Product of Glycogenolysis
Glucose
Hormones that regulate blood sugar in the body
Insulin
Glucagon
Where is glucagon produced
Pancreas (alpha cells)
Where is insulin produced
Pancreas (Beta cells)
A hormone that transports glucose inside the cell; used to decrease blood sugar levels
Insulin
Hormone to increase blood sugar levels
Glucagon
Proponent of Kreb’s Cycle
Hans Krebs
Location of Krebs’ Cycle
Mitochondria
Products of Krebs Cycle
3 NADH, 1 FADH2, 1 GTP
The main player in Krebs Cycle
Acetyl CoA
• child onset
• total destruction of beta cells
• insulin-dependent DM
• Drugs: Insulin
Type 1 Diabetes Mellitus
• adult onset
• decrease insulin sensitivity
• insulin-independent DM
• Drugs: OHAs/ Insulin
Type 2 Diabetes Mellitus
Deficiency of Uridyl Transferase
Type 1 Galactosemia
Deficiency of Galactokinase
Type 2 Galactosemia
Deficiency of Galactose Epimerase/Phosphoglucotamase
Type 3 Galactosemia
Complications in Galactosema
- Cataract in Eyes
- Mental Retardation
Hallmark / Cardinal Signs of DM
- Polyphagia (excessive hunger)
- Polydipsia (excessive thirst)
- Polyuria (excessive urination)
Deficiency of Lactase
Lactose Intolerance
Deficiency of Glucose-6-phosphatase
Von Gierke’s disease
Deficiency of Acid maltase
Pompe’s Disease
Deficiency of Debranching enzyme
Cori’s Disease
Deficiency of Branching Enzyme
Andersen’s Disease
Deficiency of Muscle glycogen phosphorylase
McArdle’s Disease
Deficiency of Liver glycogen phosphorylase
Her’s Disease
Deficiency of Muscle phosphofructokinase
Tarui’s Disease