Biochem

Question 0

On tRNA where is the anticodon found?

Answer 0

Top loop

Question 1

On t RNA where is the AA found?

Answer 1

3’ end

Question 2

B1 is cofactor for what rxns?

Answer 2

Decarboxilation. 
A- alpha ketoglutarate dehydrogenase (TCA)
T- transketolase (HMP shunt)
P- pyruvate dehydrogenase (glycolysis)
Branched chain AA dehydrogenase

Question 3

B2 cofactor in what rxns?

Answer 3

Oxidation and reduction. FAD and FMN

Question 4

B3 cofactor for what rxns?

Answer 4

Redox. NAD, NADP

Question 5

Biotin is important for what reactions?

Answer 5

Carboxylation

Question 6

B6 is important for the synthesis of what molecules?

Answer 6

Cystathionine,heme, niacin, Gaba and histamine

Question 7

Deficiency caused by raw eggs

Answer 7

Biotin

Question 8

Decreased adult hair, loss of taste, anosmia

Answer 8

Zinc deficiency

Question 9

Tryptophan derivatives

Answer 9

Niacin

Serotonin –>melatonin

Question 10

Glycine Derivatives

Answer 10

Porphyrin –> heme

Question 11

Arginine Derivatives

Answer 11

Creatine, urea, nitric oxide

Question 12

Glutamate derivatives

Answer 12

GABA, glutathione

Question 13

Dandy walker (embryology qt)

Answer 13

Large posterior fossa, absent cerebellar vermis, cystic enlargement of fourth ventricle

Question 14

Phenylalanine derivatives

Answer 14

Tyrosine -> dopa-> dopamine-> NE-> epi

Question 15

Rate limiting step for glycolysis

Answer 15

Phosphofructokinase 1

irreversible

Question 16

Rate limiting step for gluconeogenesis

Answer 16

Fructose 1,6 bisphosphatase

Question 17

Rate limiting step for TCA cycle

Answer 17

Isocitrate dehydrogenase

Question 18

Rate limiting step for glycogen synthesis

Answer 18

Glycogen synthase

Question 19

Rate limiting step for glycogenolysis

Answer 19

Glycogen phosphorylase

Question 20

Rate limiting step for HMP shunt

Answer 20

G6PDEHYDROGENASE

Question 21

Vitamin K catalyzes what reaction

Answer 21

Gamma carboxylation of glutamic acids

Question 22

What reactions take place in the mitochondria

Answer 22

Beta oxidation, acetyl CoA production, TCA cycle, oxidative phosphorylation

Question 23

What reactions take place in the cytoplasm

Answer 23

Glycolysis, fatty acid synthesis, HMP Shunt, protein synthesis, steroid synthesis

Question 24

What reactions take place both in the mitochondria and cytoplasm

Answer 24

HUGs take 2:
Heme synthesis
Urea cycle
Gluconeogenesis

Question 25

What is the rate limiting step in de novo pyrimidine synthesis

Answer 25

Carbamoyl phosphate synthetase II

Question 26

What is the rate limiting step of de novo purine synthesis

Answer 26

Glutamine PR PP aminotransferase

Question 27

What is the rate limiting step of the urea cycle

Answer 27

Carbamoyl phosphate synthetase I

Question 28

What is the rate limiting step of fatty acid synthesis

And what is the product?

Answer 28

Acetyl CoA carboxylase

Malonyl CoA

Question 29

What is the rate limiting step of fatty acid oxidation

Answer 29

Carnitine acyltransferase I

Question 30

What is the rate limiting step of ketogenesis

what is the rate limiting step of cholesterol synthesis

Answer 30

HMG CoA synthase

HMG CoA reductase

Question 31

Severe fasting hypoglycemia, increased glycogen in liver, increase blood lactate, hepatomegaly. Disease?

What enzyme is deficient?

Answer 31

VonGierkes

G6P

Question 32

Cardiomegaly systemic findings leading to Early death. Disease?

Enzyme deficiency?

Answer 32

Pompes

Lysosomal alpha 1,4 glucosidase

Question 33

Milder form of type I with normal blood lactate levels. Disease?

Enzyme deficiency?

Answer 33

Cori disease

Debranching enzyme alpha 1,6 glucosidedase

Question 34

Increased glycogen in muscle but cannot break it down. painful muscle cramps, myoglobinuria with strenuous exercise. Disease?

deficient enzyme?

Answer 34

Mc Ardle’s disease

Skeletal muscle glycogen phosphorylase