BIO 300 Exam 2 Flashcards
Sex refers to BLANK, while gender refers to BLANKS
The biology of sex interacts with complex environmental influences to produce a what? example?
Gender identity:?
Most people have a gender identity that matches their what? Environment exposed to can shape how?
Sex refers to biological sex - while gender refers to social, learned, and personal aspects of sex.
The biology of sex interacts with complex environmental influences to produce a final phenotype.
Example: Genotype says 6ft tall but phenotype is expression
Gender identity: The sense of being male or female, independent of biological genetic sex or physical appearance. Clown fish nemo example
Most people have a gender identity that matches their external appearance. Environment exposed to can shape how you are with gender but puberty does play a role.
The Genetics of Sex: sperm determines?
An individual’s genetic sex begins with sex chromosomes inherited from two parents:
Mother give what?
Father give what?
child xx is?
child xy is?
Sex chromosomal abnormalities occur?
Longitudinal study showed?
The Genetics of Sex: sperm determines gender of child by providing x or y
An individual’s genetic sex begins with sex chromosomes inherited from two parents:
- Mothers provide X chromosome
- Fathers provide either X or a Y
- A child who receives an XX is a female
- A child who receives an XY is a male
Sex chromosomal abnormalities occur in about 1 out of every 426 children.
Most sex chromosome variations produce relatively mild differences, but others are more dramatic.
Longitudinal study (study over many years with the same participants) completed with more than 13,000 newborns with three sex chromosomes instead of the normal two. Despite abnormal chromosomes most children were normal, the ones most affected were females.
Turner Syndrome definition?
what 4?
A whole person receives only a single X chromosome and is a genetic female. - only Y can not survive example like color coding gene is on X so more males are colorblind bc they on get one X but females have XX so can use the other gene.
Normal female external genitalia, but ovaries develop abnormally. Most cases ovaries can not produce eggs
Short stature
Webbed neck deformity
Normal intelligence but deficits in spatial relationships and memory
Can identify which parent passed gene bc only getting one gene
Klinefelter Syndrome def?
6 what? - require?
Phenotypically male with XXY genotype so male with extra x
Reduced fertility
Require hormone treatment at puberty to promote development of secondary male characteristics which are deep voice, adam’s apple, facile hair and must have hormones to reduce female stuff like breasts
Normal intelligence but social awkwardness
Delayed and reduced verbal skills so mild cognitive impairments
More frequent left-handedness
2 out of every 1,000 males
XYY Syndrome - other name?
what 7?
Males with XYY genotype (Jacob syndrome) males who have extra y - males 1 out of every 1,000
Tall, lean, more acne
Mild physical abnormalities of eye, elbow, and chest
Slightly lower IQ
Language difficulties and autism spectrum - autistic
Disorder are common
Fertile, but larger number of sperm with sex chromosome abnormalities
Controversial relationship to antisocial behavior - could be bc most are in low income families - also lot of poverty chromosomes
Issues of Gender Assignment and Rearing: XYY Syndrome, Klinefelter Syndrome, Turner Syndrome
Current guidelines:? what five?
Current guidelines:
- Be honest with the person/family.
-Identify gender based on predominant external genital appearance.
- Rear child as consistently as possible but be prepared that the person might later be sexually oriented toward males, females, both, or neither.
- Do not reduce ambiguous clitoris/penis to a normal sized clitoris.
Impairs erotic sensation. - When the baby is born they could look one way based on genital but it can change
The Development of the Gonads - reproductive structures processes step one
Up until the sixth gestational week, both male and female embryos have?
At about six weeks gestation, a gene on the Y chromosome, known as the WHAT gene, is expressed in male embryos.
Testis-determining factor, the protein encoded by the SRY gene, switches on additional genes that cause the primordial gonads to develop into testes.
In female embryos alternate genes, including WHAT TWO guide the development of the primordial gonad into ovaries.
Chromosomally male mice genetically modified to lack the SRY gene develop ?
Up until the sixth gestational week, both male and female embryos have identical primordial gonads that have the capacity to develop into either ovaries or testes. - first 6 weeks we all have the same parts
At about six weeks gestation, a gene on the Y chromosome, known as the sex-determining region of the Y chromosome (SRY) gene, is expressed in male embryos.
Testis-determining factor, the protein encoded by the SRY gene, switches on additional genes that cause the primordial gonads to develop into testes.
In female embryos alternate genes, including Wnt4 (located on Chromosome 1) and DAX1 (located on the X chromosome) guide the development of the primordial gonad into ovaries.
Chromosomally male mice genetically modified to lack the SRY gene develop ovaries, whereas female mice in which the SRY gene has been inserted develop testes.
Three Stages of Prenatal Development
Development of male and female reproductive structures involves three distinct processes: ?
intersex?
The development of (1) gonads(testis or ovaries), (2) internal organs, and (3) external genitalia.
In rare conditions known as intersex, elements of both male and female development occur in the same fetus. - hermaphrodite derogatory term
Differentiation of the Internal Organs
Until about the third gestational month in humans, both male and female embryos possess a male WHAT system and a female WHAT system.
Each system does what for male and female development?
At six weeks everyone has?
Until about the third gestational month in humans, both male and female embryos possess a male Wolffian system and a female Müllerian system.
In males, the Wolffian system will develop into the seminal vesicles(fluid for sperm), the vas deferens(brings sperm where it needs to go), and the prostate(ejaculation).
In females, the Müllerian system will develop into the uterus, the upper portion of the vagina, and the fallopian tubes.
At six weeks everyone has wolf and mullerian so both until spilt
During the third gestational month, the male’s testes begin to secrete two hormones?
Which two male hormones promotes the development of the Wolffian system?
Which hormone initiates the degeneration of the Müllerian system?
In the female fetus in this stage of development are hormones needed?
In the absence of which two hormones, the Müllerian system will develop in the?
In the absence of androgens, the Wolffian system ?
During the third gestational month, the male’s testes begin to secrete two hormones, testosterone and anti-Müllerian hormone.
Testosterone, one of several types of male hormone or androgen, promotes the development of the Wolffian system.
Anti-Müllerian hormone initiates the degeneration of the Müllerian system
In the female fetus, no additional hormones are needed in this stage of development.
In the absence of any androgens or anti-Müllerian hormones, the Müllerian system will develop in the typical female direction. Female do not need any extra hormones
In the absence of androgens, the Wolffian system regresses, although nonfunctional remnants can persist in adult females.
Androgen insensitivity syndrome (AIS) disrupts the normal development of WHICH system in males because of a defective gene that produces abnormal WHAT receptors, insensitive to WHAT two hormones but have bad receptors so can not receive testosterone despite how much is released. No receptor so ?
The testes release WHAT in a typical manner, but the lack of functional WHAT prevents the development of the Wolffian system.
Anti-Müllerian hormones WHAT, so the female Müllerian system also fails to develop.
External appearance is quite typically female.
Androgen insensitivity syndrome (AIS) disrupts the normal development of the Wolffian system in males because of a defective gene that produces abnormal androgen receptors, insensitive to androgen/testosterone but have bad receptors so can not receive testosterone despite how much is released. No receptor so not penis to grow one needs receptor for testosterone.
The testes release androgens and anti-Müllerian hormone in a typical manner, but the lack of functional androgen receptors prevents the development of the Wolffian system.
Anti-Müllerian hormones still work normally, so the female Müllerian system also fails to develop.
External appearance is quite typically female.
Development of the External Genitalia
The male external genitalia include the?
The female external genitalia include the?
Health care providers typically use the WHAT scale to assess the relative masculinization of the external genitalia.
An androgen WHAT must be recognized by receptor sites for the male external genitalia to develop normally. People who don’t have enough WHAT group up how?
Congenital adrenal hyperplasia (CAH) is a condition in which the?
If genetic females are exposed prenatally to excess androgens, their external genitalia become?
Females with CAH more frequently describe themselves as?
The male external genitalia include the penis and scrotum. - Hormonal stimulation is essential for the development of male external genitalia.
The female external genitalia include the labia, clitoris, and outer part of the vagina.
Health care providers typically use the Prader scale to assess the relative masculinization of the external genitalia.
An androgen, 5-alpha-dihydrotestosterone, must be recognized by receptor sites for the male external genitalia to develop normally. People who don’t have enough testosterone grow up as a female and then at puberty have penis.
Congenital adrenal hyperplasia (CAH) is a condition in which the adrenal glands release elevated levels of androgens during the second trimester of pregnancy, which is when sexual differentiation is well underway, the gonads turning. For males doesn’t do much to have extra but for girls are exposed to this so exhibit as tomboys.
If genetic females are exposed prenatally to excess androgens, their external genitalia become masculinized.
Females with CAH more frequently describe themselves as tomboys, engage in more male-interest play, and are more likely than other women to engage in bisexual and lesbian behavior.
Development at Mini-puberty:? Males experience? play?
Development at Puberty:? lead to what?
Secondary sex characteristics include for male vs female?
Development at Mini-puberty: Males experience a second surge of androgen exposure between the ages of one and three months, diminishing by about the age of six months. (PSAI scores that they were tested on) gender typical or atypical play, those with normal or growing penis have typical play boy behavior compared to those with smaller.
Development at Puberty: At puberty, additional hormonal events lead to maturation of the genitals and the development of secondary sex characteristics.
Secondary sex characteristics: include facial hair and a deeper voice for males and wider hips and breast development for females.
Typical Age at Puberty
Average age has dropped over the past 150 years. 1800 at 15 years old and then in 2020 average age WHAT? Why?
Weight?
Exposure to ?
Exposure to compounds similar to BLANK hormones in ?
All edible tissues from animals contain a type of estrogen, or female hormone, called ?
Estrogen type of WHAT like testorgen is a type of WHAT
Exposure in utero to a lot of endocrine disruptors, including WHAT might promote WHAT TWO
Phthalates(chemical in plastic)?
Researchers measured phthalate levels in pregnant women’s urine samples and compared that to sons’ toy use at ages 3 to 6.
Sons with high levels showed ???
Some of estradiol-like compounds that produce abnormalities are now prevalent in the??
Average age has dropped over the past 150 years. 1800 at 15 years old and then in 2020 average age 8-13 years old. Why better cleanness, health care, nutrient but other part is us being poisoned
Increased weight
Exposure to hormones or endocrine disruptors.
Exposure to compounds similar to female hormones in meat and dairy products, shampoo, plastics, and insecticides might also trigger earlier puberty.
All edible tissues from animals contain a type of estrogen, or female hormone, called estradiol, so we can assume that humans who consume meat have always experienced some level of exposure to outside sources of sex hormones.
Estrogen type of estradiol like testorgen is a type of androgen
Exposure in utero to a lot of endocrine disruptors, including phthalates, diethylstilbestrol (DES), and bisphenol A (BPA), might promote earlier puberty directly or by increasing obesity.
Phthalates(chemical in plastic) have been found to advance puberty in rats. Soy can be bad for you.
Phthalate exposure also appears to reduce the likelihood that boys will play with “masculine” toys.
Researchers measured phthalate levels in pregnant women’s urine samples and compared that to sons’ toy use at ages 3 to 6.
Sons with high levels showed less interest in typical boys’ toys, and more interest in typical girls’ toys.
Some of estradiol-like compounds that produce abnormalities are now prevalent in the linings of plastic bottles and cans, so almost everyone is exposed to them. - Phthalate. Found in all body organs like the brain and even babies.
Hormone Changes at Puberty
At the onset of puberty WHAT IS released by the hypothalamus.
This hormone initiates the release of two hormones by the anterior pituitary gland?????
Who male or female release these? and which affects do the hormones have like what do they produce?
At the onset of puberty, gonadotropin-releasing hormone (GnRH) is released by the hypothalamus.
This hormone initiates the release of two hormones by the anterior pituitary gland, follicle-stimulating hormone (FSH) - makes eggs on ovaries and sperm in testis and luteinizing hormone (LH) - signal males testes to produce testosterone and in females regulates menstrual cycle
Both males and females release these same hormones, but with different effects - egg vs sperm
In response to stimulation by FSH and LH, the testes begin to produce additional testosterone, and the ovaries produce estradiol.
The testes also produce small amounts of estrogens, including estradiol, and the ovaries produce small amounts of androgens, including testosterone.
In males, this burst of additional androgens stimulates muscular development, maturity of the external genitalia, facial and pubic hair, and enlargement of the larynx, which leads to a deeper voice, and Adams apple.
In conjunction with LH and FSH, testosterone begins to regulate the production of sperm.
In females, estradiol produces breast growth, maturity of the external genitalia, maturity of the uterus, and changes in fat distribution and quantity. - Estradiol can slow down skeletal growth if you get it earlier
LH and FSH regulate the menstrual cycle.
A rare condition known as WHAT affects the maturation of the male external WHAT.
This condition affects a male’s ability to produce the enzyme WHAT THAT converts WHAT
Without sufficient THIS THEN individuals are born with ambiguous external genitalia and may be raised as WHAT.
At puberty, increased levels of WHAT activate the development of secondary sex characteristics in a typical manner.
A rare condition known as 5-alpha-reductase deficiency affects the maturation of the male external genitalia.
This condition affects a male’s ability to produce the enzyme 5-alpha-reductase which converts testosterone into the more potent 5-alpha-dihydrotestosterone.
Without sufficient 5-alpha-reductase, individuals are born with ambiguous external genitalia and may be raised as females. - without enough testosterone inside out penis so you think they are females until puberty hits and they grow a penis during puberty and most will be raised as a girl but then become happy
At puberty, increased levels of testosterone activate the development of secondary sex characteristics in a typical manner.
The cascade of events begun by the actions of genes on the WHAT chromosomes is only the beginning of the story of sex and gender.
Continued expression of genes on both X and Y chromosomes, especially in the brain, hormone effects, and IN WHAT continue to push the individual in one of many possible directions.
Socialization plays a significant role in shaping WHAT
The cascade of events begun by the actions of genes on the X and Y chromosomes is only the beginning of the story of sex and gender.
Continued expression of genes on both X and Y chromosomes, especially in the brain, hormone effects, and epigenetics (environmental factors that can turn off or on genes) continue to push the individual in one of many possible directions.
Socialization plays a significant role in shaping male and female behavior, but recognizing the contributions of biology and the intricate interactions between biology and socialization enriches our understanding of sex and gender.
Males and females both produce androgens and estrogens, but in different amounts.
Example: Adult females produce about HOW MUCH amount of androgens produced by adult males?
Organization(long lasting like growing breast or adam’s apple or penis): scaffolding and building, the predetermined effect of sex hormones on body parts that you were exposed to - HAPPENS TWICE 1 VS 2
Activation:?
Example: Adult females produce about 10% of the amount of androgens produced by adult males. Males more androgens and females more estrogen and progesterone(pregnancy hormone that maintains pregnancy and works some in menstruation)
Organization(long lasting like growing breast or adam’s apple or penis): scaffolding and building, the predetermined effect of sex hormones on body parts that you were exposed to -
Happens Twice
1. Prenatal - the sexual differentiation - organize circuits of brain like anatomy of hypothalamus
2. Puberty - deepen voice, facial hair, breast
Activation: moment to moment, reversible effects of sex hormones on body structures and functions; sex hormone how much of the hormone in your body right now affects you. Activated by sex hormones through the rest of life from the circuits. Circulating hormones. Example current hormone levels impact your sex drive.
Organization During Development
Certain parts of the human brain are sexually dimorphic - ??
These differences are likely the result of different ???
Females with CAH:
Genetic females with CAH had extra ?
Pregnancies who are given CAH and have more?
Certain parts of the human brain are sexually dimorphic - males and females differ in brain areas like hypothalamus and pituitary gland
These differences are likely the result of different prenatal hormonal environments.
Females with CAH:
Genetic females with CAH had extra androgens during prenatal period so are partly masculine in genitalia and in behavior and more likely gay and tomboys and in male play
Pregnancies who are given CAH and have more testosterone than are affected more prenatally. CAH are always in the middle between typical females and typical male so the difference is had extra testosterone during developmental periods.
Play behavior: Sex differences in play behavior
Toy choices by girls with CAH ? Girls without CAH play ? Boys who have CAH? healthy boys ?
In one study, infants 3 to 8 months old (too young to walk, crawl, or do much with a toy) sat in front of pairs of toys, where researchers could monitor eye movements. Girls liked ? and boys liked?
Children begin to prefer sex-typed toys between the ages of ? tells us what about prefrence?
In several studies with monkeys???
Toy choices by girls with CAH are significantly more likely to be in the masculine direction than in the feminine direction. Girls without CAH play with girls toys vs girls who have CAH play with boys toys more but are still in the middle between boys and girls toys. Boys who have CAH are just extra testosterone so does not see a big difference in healthy boys or those with CAH.
In one study, infants 3 to 8 months old (too young to walk, crawl, or do much with a toy) sat in front of pairs of toys, where researchers could monitor eye movements. Girls liked dolls and boys liked trucks - take with grain of salt but no for sure at one year old do start to prefer because grab what they want.
Children begin to prefer sex-typed toys between the ages of 12 and 18 months
- At these ages, they are unable to match sex-typed toys with male or female faces or voices, suggesting that they have not yet been socialized to think of toys as male or female.
So, some about socialization and some about a biologically preference
In several studies male monkeys played with balls and toy cars more than female monkeys did, whereas the females played more with dolls.
Socialization is even less likely to play a role in the toy choices of these monkeys.
Blue and pink is socialization and not biological
Gender identity is defined as a person’s?
In transsexuality?
Females with CAH - transsexuality?
Gender identity is defined as a person’s self-concept as male or female and is usually viewed as the product of years of socialization.
In transsexuality, a person’s gender identity is inconsistent with his or her biological sex and can be resolved with sex-reassignment surgery and hormonal treatment.
Females with CAH - transsexuality in biological females is rare 3% but women with CAH is 600 times more likely to be transsexuality
Many studies have pointed to higher empathy in ?
Females with CAH?
Lowest with testosterone more?
Males (both human and nonhuman) have been shown to have a slight advantage in ?
Females have a slight advantage in?
Visuospatial skills are correlated with?
Mental Rotation task who is better?
A number of psychological disorders?
Many studies have pointed to higher empathy in females and higher levels of physical aggression in males. The higher the testosterone the lower the empathy score.
Females with CAH(prenatal higher levels of testosterone released - so decreased empathy) and decreased empathy and more aggression
Lowest with testosterone more empathy
Males (both human and nonhuman) have been shown to have a slight advantage in visuospatial tasks - cognition
Females have a slight advantage in verbal tasks and episodic memory, or memory for events in a personal timeline.
Visuospatial skills are correlated with current, not necessarily prenatal, testosterone levels in both men and women.
Mental Rotation task - males are better bc of testosterone and worse when estrogen is high
A number of psychological disorders show big differences in prevalence rates for men and women. Autism is more males and depression is more females.
Sexual orientation refers to?
Early exposure to sex hormones influences adult sexual behavior in animals and humans. If you do or don’t have testosterone exposure prenatally impacts?
Birth order:
Males with older brothers are more likely to be ?
Mother’s immune response to ?
Sexual orientation refers to a stable pattern of attraction to members of a particular sex.
Approximately 1.8 percent of adult males and 1.5 percent of adult females identify themselves as gay or lesbian, and 0.4 percent of men and 0.9 percent of women describe themselves as bisexual.
Early exposure to sex hormones influences adult sexual behavior in animals and humans. If you do or don’t have testosterone exposure prenatally impacts sexual behavior, low testosterone in males are less likely to engage with females.
Birth order:
Males with older brothers are more likely to be homosexual
Mother’s immune response to Y chromosome proteins may strengthen with subsequent pregnancies
Sexually dimorphic structures also differ according to sexual orientation in males.
INAH-3 (hypothalamus) is smaller among?
Lesions in monkeys’ INAH-3 impairs?
INAH-3 was two to three times larger in?
Anterior commissure?
INAH-3 Size Correlates with?
Genetics appear to influence sexual orientation, although the exact mechanisms are not well understood and are likely to be quite complex:
The chances of a homosexual male twin having a homosexual brother are WHAT% for fraternal twins(share environment not genes) and about WHAT% for identical twins.
If a homosexual orientation depends on certain genes, why hasn’t evolution selected strongly against those genes?
INAH-3 (hypothalamus) is smaller among women and homosexual men than among heterosexual men.
Lesions in monkeys’ INAH-3 impairs heterosexual behavior but not overall sex drive.
INAH-3 was two to three times larger in heterosexual males than in homosexual males.
Anterior commissure - bundle of fibers that brings info connected to the cerebral hemispheres and is sexually dimorphic and is largest in homosexual males, then heterosexual females, smallest in heterosexual males.
INAH-3 Size Correlates with Sexual Orientation
Genetics appear to influence sexual orientation, although the exact mechanisms are not well understood and are likely to be quite complex:
The chances of a homosexual male twin having a homosexual brother are 20 to 25% for fraternal twins(share environment not genes) and about 50% for identical twins.
If a homosexual orientation depends on certain genes, why hasn’t evolution selected strongly against those genes?
Genes may be maintained by kin selection.
Even if homosexual people do not have children themselves, they might do a wonderful job of helping their brothers and sister’s rear children.