Bile Acid Sequestrants

Question 1

MOA?

Answer 1

• decreases in LDL
• They bind to bile acid, preventing their reabsorption in the liver, leading to elimination in the feaces

Question 2

ADRs?

Answer 2

• GI disturbance
• interference with fat soluble vitamins (supplementation may be required)

Question 3

CI

Answer 3

• bowel obstruction

Question 4

Can it be used in pregnancy

Answer 4

Yes

Question 5

Which agent of bile acid sequestrants can relive itchiness caused by accumulation of bile acids?

Answer 5

Cholestyramine