Biguanides Flashcards
1
Q
Biguanides mechanism is action?
A
Increase insulin sensitivity,
Decrease hepatic glucose production
2
Q
Name the biguanides
A
Metformin
3
Q
Metformin AKA
A
Glucophage (XR)
4
Q
Glucophage AKA
A
Metformin
5
Q
Metformin’s impact on AIC?
A
1-2%
6
Q
Contraindications for Metformin
A
Severe CHF,
Renal impairment with SCr> 1.4 female or > 1.5 male,
Liver disease, ETOH abuse,
? >80 years old
May reduce B12 (1000 micrograms may do it, to treat)