BI233 Indolent Lymphoproliferative Disorders Flashcards
what is the median age of onset for follicular lymphoma?
65
What is the most common presentation of follicular lymphoma?
- most presentation is asymptomatic
- generally similar presentation to other types of lymphoma
do FL patients have constitutional symptoms?
only 20% of people with FL present with constitutional symptoms
how common is FL
the most or second most common type of lymphoma in developed countries
What is the aim of treatment for FL?
disease response and remission
Do we treat patients who are not symptomatic?
No
what is the prognosis of someone with FL?
10 year overall survival is 30-70%
What are the risk factors associated with adverse prognosis in FL?
1) Age >60
2) elevated LD
3) Hb
What form of cancer can FL transform into?
diffuse large B-cell lymphoma
What is the normal lymphocyte count on blood smear?
less than 3
What is CLL?
Chronic Lymphocytic Leukemia; ,It is the most common type of leukemia (a type of cancer of the white blood cells) in adults. CLL affects B cell lymphocytes. B cells grow in an uncontrolled manner and accumulate in the bone marrow and blood, where they crowd out healthy blood cells
what is another name for CLL?
Small lymphocytic lymphoma. The name depends on the presentation, but same biology.
What 2 findings characterize CLL?
1) increased abnormal clonal lymphocyte count
2) enlarged lymph nodes
What is the median age of diagnosis for CLL?
70
TRUE OR FALSE: CLL is the 2nd most common leukaemia in adults
FALSE: Leukemia is the MOST common leukaemia in adults
TRUE OR FALSE: CLL has a higher incidence in caucasians than other groups
TRUE
What test do you order to diagnose CLL?
peripheral blood flow cytometry
What should the B count be to diagnose CLL?
B count > 5 x 10^9/L
What is the diagnosis if the B count is less than 5 x 10^9/L with no lymph nodes/symptoms
monocloncal B-cell lymphocytosis
What is the diagnosis if the B cell count is less than 5 x 10^9/L but with enlarged lymph nodes
small lymphocytic lymphoma
Do we treat patients who are asymptomatic and have CLL?
no, just regular monitoring to look for signs and progression, new symptoms
what causes multiple myeloma?
caused by an abnormal clone of plasma cells producing an abnormal antibody (monoclonal protein)
TRUE OR FALSE: Multiple Myeloma is more common in young adults
FALSE: Multiple Myeloma is more common in older adults
What is the clinical presentation of Multiple Myeloma?
CRAB
1) Hypercalemia
2) Renal disease
3) Anemia
4) Bone Pain
