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BI2 > BI233 Indolent Lymphoproliferative Disorders > Flashcards

BI233 Indolent Lymphoproliferative Disorders Flashcards

1
Q

what is the median age of onset for follicular lymphoma?

A

65

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2
Q

What is the most common presentation of follicular lymphoma?

A
  • most presentation is asymptomatic

- generally similar presentation to other types of lymphoma

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3
Q

do FL patients have constitutional symptoms?

A

only 20% of people with FL present with constitutional symptoms

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4
Q

how common is FL

A

the most or second most common type of lymphoma in developed countries

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5
Q

What is the aim of treatment for FL?

A

disease response and remission

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6
Q

Do we treat patients who are not symptomatic?

A

No

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7
Q

what is the prognosis of someone with FL?

A

10 year overall survival is 30-70%

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8
Q

What are the risk factors associated with adverse prognosis in FL?

A

1) Age >60
2) elevated LD
3) Hb

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9
Q

What form of cancer can FL transform into?

A

diffuse large B-cell lymphoma

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10
Q

What is the normal lymphocyte count on blood smear?

A

less than 3

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11
Q

What is CLL?

A

Chronic Lymphocytic Leukemia; ,It is the most common type of leukemia (a type of cancer of the white blood cells) in adults. CLL affects B cell lymphocytes. B cells grow in an uncontrolled manner and accumulate in the bone marrow and blood, where they crowd out healthy blood cells

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12
Q

what is another name for CLL?

A

Small lymphocytic lymphoma. The name depends on the presentation, but same biology.

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13
Q

What 2 findings characterize CLL?

A

1) increased abnormal clonal lymphocyte count

2) enlarged lymph nodes

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14
Q

What is the median age of diagnosis for CLL?

A

70

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15
Q

TRUE OR FALSE: CLL is the 2nd most common leukaemia in adults

A

FALSE: Leukemia is the MOST common leukaemia in adults

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16
Q

TRUE OR FALSE: CLL has a higher incidence in caucasians than other groups

A

TRUE

17
Q

What test do you order to diagnose CLL?

A

peripheral blood flow cytometry

18
Q

What should the B count be to diagnose CLL?

A

B count > 5 x 10^9/L

19
Q

What is the diagnosis if the B count is less than 5 x 10^9/L with no lymph nodes/symptoms

A

monocloncal B-cell lymphocytosis

20
Q

What is the diagnosis if the B cell count is less than 5 x 10^9/L but with enlarged lymph nodes

A

small lymphocytic lymphoma

21
Q

Do we treat patients who are asymptomatic and have CLL?

A

no, just regular monitoring to look for signs and progression, new symptoms

22
Q

what causes multiple myeloma?

A

caused by an abnormal clone of plasma cells producing an abnormal antibody (monoclonal protein)

23
Q

TRUE OR FALSE: Multiple Myeloma is more common in young adults

A

FALSE: Multiple Myeloma is more common in older adults

24
Q

What is the clinical presentation of Multiple Myeloma?

A

CRAB

1) Hypercalemia
2) Renal disease
3) Anemia
4) Bone Pain

25
Q

What condition do you have if you have abnormal monoclonal protein but have none of the CRAB criteria?

A

you either have MGUS or soldering myeloma

26
Q

what does MGUS stand for?

A

monoclonal protein of undetermined significance

27
Q

Which of the two, Smoldering myeloma or MGUS has a higher burden of disease?

A

smoldering myeloma

28
Q

How do you treat multiple myeloma?

A

1) multi agent chemotherapy

2) bisphosphonate in all patients

29
Q

What test is done when suspecting multiple myeloma?

A

serum protein electrophoresis (SPEP)

30
Q

What is a smudge cell?

A

remnants of cells that lack any identifiable cytoplasmic membrane or nuclear structure. Smudge cells, also called basket cells, are most often associated with abnormally fragile lymphocytes in disorders such as chronic lymphocytic leukemia (CLL)

31
Q

What pathological markers are associated with FL?

A

CD20+ and CD5+

32
Q

What pathological markers are associated with CLL?

A

CD20+, CD5+, smudge cells

33
Q

What pathological markers are associated with Multiple Myeloma?

A

Monocloncal protein present on SPEP

BI2 (10 decks)

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