BI227 Overview of Thrombosis

Question 1

What are the components of Virchow’s Triad?

Answer 1

1) abnormal flow
2) abnormal vessel wall
3) abnormal coagulability

Question 2

What are the manifestations of arterial thrombosis?

Answer 2

ischemia, infarction

Question 3

what are the manifestations of venous thrombosis?

Answer 3

congestion, swelling

Question 4

What is the mechanism of a venous thromboembolism?

Answer 4

1) stasis

2) hypercoagulability

Question 5

What is the most important risk factor for arterial thrombosis?

Answer 5

abnormal vessel wall

Question 6

What are other hypercoagulability risk factors that contribute to the risk of arterial and venous thrombosis?

Answer 6

1) antiphospholipid antibodies
2) oral contraceptives
3) myeloproliferative disorders and PNH
4) heparin-induced thrombocytopenia

Question 7

what is the multiple hit model?

Answer 7

the overall risk of venous thromboembolism is the product of independent risks. Ex. events are most likely to occur in patients with one or more biochemical hypercoagulable defects

Question 8

what is the favoured tests to diagnose venous thrombosis?

Answer 8

duplex ultrasound

Question 9

what is the favoured test to diagnose arterial thrombosis?

Answer 9

enzymes (MI), CT (stroke)

Question 10

What is the favoured test to diagnose pulmonary embolism?

Answer 10

spiral CT scan

Question 11

List the treatment types for arterial thrombosis

Answer 11

1) thrombolytics
2) antiplatelet agents
3) anticoagulants

Question 12

list the treatment types for venous thrombosis

Answer 12

1) anticoagulation

2) vena cava filter