BI203 Ch. 25 - Online Quiz (MC) Flashcards
___ = The development of new blood vessels.
Angiogenesis
Burkitt’s lymphoma is caused almost exclusively by ___ of the c-myc proto-oncogene.
translocation
A ___ tumor has the ability to spread to other tissues and to initiate tumors at secondary sites, whereas a ___ tumor does not spread.
malignant, benign
Mutations in tumor suppressors: Smad2, Smad4, APC, and p53, have all been associated with ___ cancer.
colon cancer
People infected with HIV are more susceptible to acquiring certain types of cancer because these individuals are ___.
immunosuppressed
Oncogenic conversion of the two dimerizing proto-oncogene components of the AP-1 transcription factor can lead to abnormal cell proliferation. Which of the following two gene products form the active AP-1 transcription factor complex?
___ and ___.
Fos and Jun
___ is a cancer that begins in cells involved in the immune system.
Lymphoma
Point mutations that deregulate protein activity are common among viral oncogenes, such as the ___ oncogenes.
ras
The gene E1B is expressed by ___.
adenoviruses
Which of the following genes is expressed by SV40 (simian virus 40) and induces transformation?
The gene encoding large T antigen
Malignant cells also secrete ___ that digest extracellular matrix components.
proteases
Infection with ___ ___ ___ is associated with the development of liver cancers in humans.
hepatitis B viruses
Pioneering work by Judah Folkman led to a class of anticancer drugs, such as sunitinib and sorafenib. These drugs function by inhibiting the formation of ___ ___ ___ in the vicinity of the tumor.
new blood vessels
Papillomaviruses are associated with ___ cancers.
cervical cancers (of the cervix)
___ is a lipid phosphatase that dephosphorylates PIP3 to PIP2. It has the opposite effect of PI 3-kinase. It is a tumor suppressor gene.
PTEN
___ contributes to cancer development by providing nutrients and oxygen to tumors and by facilitating metastasis.
Angiogenesis
Of the more than 40 oncogenic retroviruses that have been identified, they share expression of the genes:
pol, env, gag
Of the more than 40 oncogenic retroviruses that have been identified, they share expression of all of the following genes EXCEPT:
src
The majority of oncogene proteins are components of signaling pathways that regulate cell ___.
proliferation
