BI203 Ch. 25 - Online Quiz (MC)

Question 1

___ = The development of new blood vessels.

Answer 1

Angiogenesis

Question 2

Burkitt’s lymphoma is caused almost exclusively by ___ of the c-myc proto-oncogene.

Answer 2

translocation

Question 3

A ___ tumor has the ability to spread to other tissues and to initiate tumors at secondary sites, whereas a ___ tumor does not spread.

Answer 3

malignant, benign

Question 4

Mutations in tumor suppressors: Smad2, Smad4, APC, and p53, have all been associated with ___ cancer.

Answer 4

colon cancer

Question 5

People infected with HIV are more susceptible to acquiring certain types of cancer because these individuals are ___.

Answer 5

immunosuppressed

Question 6

Oncogenic conversion of the two dimerizing proto-oncogene components of the AP-1 transcription factor can lead to abnormal cell proliferation. Which of the following two gene products form the active AP-1 transcription factor complex?

___ and ___.

Answer 6

Fos and Jun

Question 7

___ is a cancer that begins in cells involved in the immune system.

Answer 7

Lymphoma

Question 8

Point mutations that deregulate protein activity are common among viral oncogenes, such as the ___ oncogenes.

Answer 8

ras

Question 9

The gene E1B is expressed by ___.

Answer 9

adenoviruses

Question 10

Which of the following genes is expressed by SV40 (simian virus 40) and induces transformation?

Answer 10

The gene encoding large T antigen

Question 11

Malignant cells also secrete ___ that digest extracellular matrix components.

Answer 11

proteases

Question 12

Infection with ___ ___ ___ is associated with the development of liver cancers in humans.

Answer 12

hepatitis B viruses

Question 13

Pioneering work by Judah Folkman led to a class of anticancer drugs, such as sunitinib and sorafenib. These drugs function by inhibiting the formation of ___ ___ ___ in the vicinity of the tumor.

Answer 13

new blood vessels

Question 14

Papillomaviruses are associated with ___ cancers.

Answer 14

cervical cancers (of the cervix)

Question 15

___ is a lipid phosphatase that dephosphorylates PIP3 to PIP2. It has the opposite effect of PI 3-kinase. It is a tumor suppressor gene.

Answer 15

PTEN

Question 16

___ contributes to cancer development by providing nutrients and oxygen to tumors and by facilitating metastasis.

Answer 16

Angiogenesis

Question 17

Of the more than 40 oncogenic retroviruses that have been identified, they share expression of the genes:

Answer 17

pol, env, gag

Question 18

Of the more than 40 oncogenic retroviruses that have been identified, they share expression of all of the following genes EXCEPT:

Answer 18

src

Question 19

The majority of oncogene proteins are components of signaling pathways that regulate cell ___.

Answer 19

proliferation