BI203 Ch. 24 - Online Quiz (MC) Flashcards
Which of the following diseases would not be an ideal target for therapeutic cloning?
HIV
Which of the following products would result from caspase cleavage of a protein with the amino acid sequence AVEELCSTWYYDLLCHMRTL?
AVEELCSTWYYD + LLCHMRTL
The PI 3-kinase pathway activates Akt, which does ___ activate Bad.
NOT
The cloned embryo in somatic cell nuclear transfer is ___ genetically identical to the foster mother.
NOT
Apoptosis, or programmed cell death, occurs in all of the following cases except in ___ ___ ___.
cells damaged by injury
The following is a signal transduction cascade (with one missing step) initiated by double-stranded DNA damage and ending with activation of apoptosis by the BH3-only proteins PUMA and Noxa: Double-stranded DNA damage; Chk2; ___; PUMA/Noxa; apoptosis. Which protein belongs in the blank space?
p53
TNF binds a trimeric receptor complex on the surface of the cell membrane.
Upon receptor binding, ___ is activated through an adaptor protein.
___ then activates ___, which in turn activates Bax and Bak and then feeds into the mitochondrial pathway.
Caspase-8, Bid
Murine embryonic stem cells are grown in the presence of a growth factor. What growth factor is generally used for this?
LIF (Leukemia Inhibitory Factor)
___ is used to stimulate growth of fibroblasts.
PDGF (platelet-derived growth factor)
Tumors are ___ considered viable stem cells.
NOT
What is the best rationale for the use of therapeutic cloning to replace defective cells or tissues in a patient?
The transplanted cells are ___ to those of the recipient who donated the adult nucleus, so complications of immune rejection are ___.
identical, avoided
When activated, Bax and Bak form oligomers in the outer membrane of mitochondria, leading to the release of ___ ___.
cytochrome c
