Beta Oxidation Of Fatty Acids Flashcards
What are fatty acids converted to and where?
Enzymes?
Fatty acid —(ATP=ADP)—> Acyl adenylate —(acyl CoA synthase) —> Acyl CoA
Where does this take place?
Cytoplasm
Where is Acyl CoA shuttled to after?
Carnitine shuttle into mitochondrial matrix
More than 12 C in FA
Which part of this cycle is the rate limiting step?
The cartinine shuttle
What happens to the Acyl CoA in the mitochondria?
In peroxisomes
Undergoes oxidation and hydrolysis reactions
What is produced inside the mitochondria after the ox and hydrolysis reactions?
Acetyl CoA
Where does Acetyl CoA go?
Krebs cycle
Excess-ketogenesis
How much of the Body’s ATP does beta oxidation produce?
60% +
More than glucose
What happens when there’s excess acetyl CoA?
Ketogenesis takes place (in the liver)
What is acetyl CoA converted to?
Acetate, acetoacetate, beta hydroxybutyrate
What are all of these?
Ketones
Inactive, storage like
What happens when acetyl CoA is needed?
Ketones reversed back to acetyl CoA for link reaction
Where does ketogenesis occur?
In liver
Hepatocytes
What is diabetic ketoacidosis due to?
Results from a reduced supply of glucose and increased fatty acid conc
increased ketone conc in blood
Decreased blood glucose
Increased acidity (ketones = weak acids) affects Hb
Why can’t liver use ketones for fuel ?
Doesn’t have enzyme that converts ketone to acetyl CoA
