Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 2nd Sem Prelim > Beta Lactam Others > Flashcards

Beta Lactam Others Flashcards

1
Q

Clavulanic Acid + Amoxicillin

Beta lactam inhibitors

A

Augmentin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Clavulanate K + Ticarcillin

Beta lactam inhibitors

A

Timentin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sulbactam Pivoxil + Ampicillin

Beta lactam inhibitors

A

Unasyn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tazobactam + Piperacillin

Beta lactam inhibitors

A

Tazocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

beta-lactamase producing Gramnegative organisms, which were resistant to broad spectrum and extended spectrum penicillins

A

CARBAPENEMS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

P. aeruginosa –except

A

Ertapenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Febrile neutropenic patients

A

imipenem, meropenem, doripenem +/-aminoglycoside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

inactivated by dehydropeptidases in renal tubules resulting in low urinary concentrations

A

Imipenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

penetrates body tissues and fluids well including the CSF

•binds to penicillin binding proteins

A

Imipenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Imipenem indications

A 
Urinary tract infection, 
lower respiratory tract infection, 
intraabdominaland gynecologic; 
skin, soft tissue, bone and 
joint infections
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

not degraded by dehydropeptidase, thus no cilastatinis needed. •Excessive levels in kidney failure can cause seizures with imipenembut not with

A

Meropenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Ertapenem

A

longest half life, once a day dosing ( 1 gram IV)
•Irritating IM so may give 1% lidocaine
•Less active than the other carbapenems against pseudomonas and acinetobacter
•Not degraded by dyhydropepetidases •Insufficiently active against P. aeruginosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Similar to imipenem •Sligthly greater activity against gram negative aerobes and slightly less activity against gram positive •Not degraded by dihydropeptidases

A

Doripenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MOA –inhibits cell wall synthesis-binds firmly to D-Ala-D-Ala terminus of nascent peptidoglycan pentapeptide-inhibits transglycosylate,preventing further elongation of peptidoglycan and x-linking

A

Vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Vancomycin resistance

A

D-Ala-D-Ala binding site of the peptidoglycan building block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vancomycin can cause

A

red man or red neck syndrome

17
Q

meningitis of pen resistant strain of pneumococcus

Vancomycin +

A

Cefotaxime,
Ceftriaxone or
Rifampicin

18
Q

enterococcal endocarditis (Enterococcus faecium and E. faecalis

Vancomycin plus

A

Gentamycin

19
Q

Very similar to vancomycin •Can be given IM & IV •OD •T ½ = 45-70 hours

A

Teicoplanin

20
Q

Semisynthetic lipoglycopeptide derived from teicoplanin
•Same MOA with vancomycin
•Improved activity against gram (+) bacteria, MRSA and vancomycin-intermediate S. aureus
•Not active against vancomycin resistant enterococci

A

Dalbavancin

21
Q

Inhibits cell wall synthesis by binding to the D-Ala-D-Ala terminus of peptidoglycan in the growing cell wall
•Targets the bacterial cell membrane & causes disruption of membrane potential & increases permeability

A

Telavancin

22
Q

inhibits cytoplasmic enzyme enol pyruvate transferase by covalently binding to the cysteine residue of the active site

A

Fosfomycin

23
Q

inhibits cell wall formation by interfering with dephosphorylationin cycling of the lipid carrier that transfers peptidoglycansubunits to the growing cell wall •Nephrotoxic; topical use

A

Bacitracin

24
Q

Analog of D-alanine, inhibiting its incorporationinto the peptidoglycan pentapeptide by inhibiting alanine racemase, which converts L-alanine to D-alanine and D-alanylD-alanine ligase

From Streptomyces orchidaceous

A

Cycloserine

25
Q

Novel cyclic lipopeptide fermentation product of Streptomyces roseosporus
•Similar activity with vancomycin except that it is more rapidly bactericidal in vitro and it is active against vancomycinresistant strains of enterococci and staph aureus

A

Daptomycin

26
Q

Binds reversibly to the 305 sub unit of the bacterial ribosome –blocks the binding of amino –acyl t RNA on the MRNA –ribosomes complex
•Active against q(+) and q(-‐) bacteria, angerobes, rickettsiae, chlamydige, mycoplasm

A

Tetracycline

27
Q

tears and saliva –useful for the eradication of meningococcal state

A

Minocyclin

28
Q

more preferred (minocycline resistance

A

Rifampicin

29
Q

Short acting tetracycline

A

Chlortetracycline

b. Tetracycline
c. Oxytetracycline

30
Q

Intermediate tetracycline

A

Demeclocycline b.Methacycline

31
Q

Long acting tetracycline

A

Doxycycline b.minocycline

32
Q

Macrolides

A

Hindi pa tapos onwards

33
Q

MOA: interacts with penicillin binding proteinsand induces the formation of long filamentous bacteria-resembles ceftazidime in structure

A

Monobactam: Aztreonam

Pharmacology 2nd Sem Prelim (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions