Antihelmentic Agents

Question 1

Antihelminthic agents

MOA

Answer 1

Inhibit microtubule synthesis in nematodes

Impaired glucose uptake

Question 2

Antihelminthic agents

Availability

Answer 2

Zentel 400 mg tab and 200mg /5ml

Question 3

Mebendazole

Answer 3

Ascaris
Trichuriasis
Hookworm

Question 4

Mebendazole

Availability

Answer 4

Antiox 100 mg x 3 days

500mg tab x1day

Question 5

Alternative drug for the treatment of strongyloidiasis and cutaneous larva migrans

Answer 5

Thiabendazole

Question 6

Thiabendazole

Same MOA as

Answer 6

Albendazole

Question 7

Thiabendazole

Has anti inflammatory properties,

Answer 7

Effects on T cell function

Question 8

Thiabendazole

Trichinosis

Answer 8

25mg/kg BID x 7 days

Question 9

Thiabendazole

Strongyloidiasis

Answer 9

25 mg /kg in 3 divided doses x 2 days

Question 10

Drug of choice for the treatment of fascioliasis

Answer 10

Bithionol

Question 11

Bithionol

AE

Answer 11

Abdominal cramps

Caution in children

Question 12

Bithionol

Alternative drug for

Answer 12

Pulmonary paragonimiasis

Question 13

Drug of choice for the treatment of filariasis, loiasis and tropical eosinophilia

Answer 13

Diethylcarbamazine citrate

Question 14

Diethylcarbamazine citrate

MOA

Answer 14

Immobilizes the microfilariae and alters their surface structure, making them more susceptible to destruction by host defense mechansim

Question 15

Diethylcarbamazine citrate

Prophylaxis

Answer 15

50 mg monthly (lymphatic filariasis)

Question 16

Are alternative drugs for the treatment of fasciola hepatica infection

Answer 16

Emetine hydrochloride

Question 17

Strongyloidiasis and onchoercosis

Answer 17

Ivermectin

Question 18

Alternative drug for scabies and filariasis

Answer 18

Ivermectin

Question 19

Ivermectin

No known toxic effect because of

Answer 19

It no enter the blood brain barrier

Question 20

Ivermectin

MOA

Answer 20

Modulates GABA mediated neurotransmission

Question 21

Ivermectin

AE

Answer 21

Mazzoti reaction

Question 22

Ivermectin

CI

Answer 22

Children younger than 5years of age or to those weighing less than 15kg
Pregnant
Nursing mother first week

Question 23

Highly effective in eradicating ascaris and trichostrongylus and moderately effective against both species of hookworm

Answer 23

Levamisole

Question 24

Depolarizing muscular blocking agents (ACH)

Answer 24

Oxantel pamoate/pyrantel pamoate

Question 25

Effective in the treatment of schistosomes infection of all species and most other

Answer 25

Praziquantel

Question 26

Praziquantel

Answer 26

Trematode Cestode Cysticercosis

Question 27

Praziquantel MOA

Answer 27

Drug increase cell membrane permeability to calcium, resulting vacuolization, marked contraction, paralysis Dislodgement Death

Question 28

Praziquantel Preparation

Answer 28

600mg

Question 29

Deworming - 12-59months old: mebendazole 500mg single dose OR Albendazole 400 mg single dose

Answer 29

Integrated management of childhood illness 2008

Question 30

Drug of choice for the treatment of Hydatid disease, neuro cysticercosis and cutaneous larva migrans

Answer 30

Albendazole