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Pharmacology 2nd Sem Prelim > Antihelmentic Agents > Flashcards

Antihelmentic Agents Flashcards

1
Q

Antihelminthic agents

MOA

A

Inhibit microtubule synthesis in nematodes

Impaired glucose uptake

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2
Q

Antihelminthic agents

Availability

A

Zentel 400 mg tab and 200mg /5ml

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3
Q

Mebendazole

A

Ascaris
Trichuriasis
Hookworm

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4
Q

Mebendazole

Availability

A

Antiox 100 mg x 3 days

500mg tab x1day

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5
Q

Alternative drug for the treatment of strongyloidiasis and cutaneous larva migrans

A

Thiabendazole

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6
Q

Thiabendazole

Same MOA as

A

Albendazole

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7
Q

Thiabendazole

Has anti inflammatory properties,

A

Effects on T cell function

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8
Q

Thiabendazole

Trichinosis

A

25mg/kg BID x 7 days

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9
Q

Thiabendazole

Strongyloidiasis

A

25 mg /kg in 3 divided doses x 2 days

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10
Q

Drug of choice for the treatment of fascioliasis

A

Bithionol

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11
Q

Bithionol

AE

A

Abdominal cramps

Caution in children

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12
Q

Bithionol

Alternative drug for

A

Pulmonary paragonimiasis

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13
Q

Drug of choice for the treatment of filariasis, loiasis and tropical eosinophilia

A

Diethylcarbamazine citrate

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14
Q

Diethylcarbamazine citrate

MOA

A

Immobilizes the microfilariae and alters their surface structure, making them more susceptible to destruction by host defense mechansim

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15
Q

Diethylcarbamazine citrate

Prophylaxis

A

50 mg monthly (lymphatic filariasis)

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16
Q

Are alternative drugs for the treatment of fasciola hepatica infection

A

Emetine hydrochloride

17
Q

Strongyloidiasis and onchoercosis

A

Ivermectin

18
Q

Alternative drug for scabies and filariasis

A

Ivermectin

19
Q

Ivermectin

No known toxic effect because of

A

It no enter the blood brain barrier

20
Q

Ivermectin

MOA

A

Modulates GABA mediated neurotransmission

21
Q

Ivermectin

AE

A

Mazzoti reaction

22
Q

Ivermectin

CI

A

Children younger than 5years of age or to those weighing less than 15kg
Pregnant
Nursing mother first week

23
Q

Highly effective in eradicating ascaris and trichostrongylus and moderately effective against both species of hookworm

A

Levamisole

24
Q

Depolarizing muscular blocking agents (ACH)

A

Oxantel pamoate/pyrantel pamoate

25
Q

Effective in the treatment of schistosomes infection of all species and most other

A

Praziquantel

26
Q

Praziquantel

A

Trematode
Cestode
Cysticercosis

27
Q

Praziquantel

MOA

A

Drug increase cell membrane permeability to calcium, resulting vacuolization, marked contraction, paralysis
Dislodgement
Death

28
Q

Praziquantel

Preparation

A

600mg

29
Q

Deworming - 12-59months old: mebendazole 500mg single dose OR
Albendazole 400 mg single dose

A

Integrated management of childhood illness 2008

30
Q

Drug of choice for the treatment of Hydatid disease, neuro cysticercosis and cutaneous larva migrans

A

Albendazole

Pharmacology 2nd Sem Prelim (7 decks)

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