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Pharmacology 2nd Sem Prelim > Beta Lactam Cephalosphorin > Flashcards

Beta Lactam Cephalosphorin Flashcards

1
Q

Parent compound of cephalosporin

A

7 amino-cephalosporanic acid

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2
Q

Cephalosporin generally more effective than Penicillinsagainst B-lactamase-producing microbes

A

except enterococci,
Methicillin-resistant Staph.
Aureus and Staph epidermidis

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3
Q

Good activity vs gm (+) & modest vs gm (-) microbes ( ex: strep, staph, E. coli, K. pneumoniae, Proteus mirabilis) and anaerobes ( ex: peptococci, peptostreptococci)
•Penetration to the CSF is inadequate

A

First generation of cephalosporin

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4
Q

Oral drugs used for the treatment of UTI, for minor staphylococcal lesions, or for minor polymicrobial infections such as cellulitis or soft tissue abscess

A

First generation of cephalosporin

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5
Q

penetrates well into most tissues-the drug of choice for surgical prophylaxis

1st gen

A

Cefazolin

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6
Q

only first generation parenteral cephalosphorin
•Alternative to an antistaphylococcal penicillin

1st gen

A

Cefazolin

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7
Q

Better activity vs anaerobes

•first gen drugs activity but with extended gm (-) coverage (beta-lactamase-producing

A

Second generation cephalosporin

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8
Q

Clinical uses: sinusitis, otitis

A

2ndgeneration

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9
Q

B. fragilis and some serratia strains (mixed anaerobic infections like peritonitis, diverticulitis, PID) ; colorectal surgery

2nd gen

A

Cefoxitin,
cefmetazole and
cefotetan

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10
Q

H. influenzae,
M. catarrhalis

2nd gen

A 
Cefamandole, 
cefuroxime, 
cefonicid, 
ceforanide & 
cefaclor
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11
Q

pneumococcus
–crosses the BBB & for community-acquired pneumonia

2nd gen

A

Cefuroxime

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12
Q

less active than the first generation vs gm (+) cocci but most active against gram (-) including B-lactamase-producing strains

A

3rd generation

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13
Q

DOC P. meningitis)–more active against Pseudomonas

3rd gen

A

Cefoperazone,

Ceftazidime

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14
Q

active against anaerobes

3rd gen

A

Cefoperazone,

Cefotaxime

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15
Q

active against B. fragilis

3rd gen

A

Ceftizoxime

and monolactam

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16
Q

meningitis caused by pneumococci, meningocci, H. influenzae& susceptible gram (-) enteric rods Penicillin resistant strains of pneumococci

3rd gen

A

Ceftriaxone & cefotaxime+ vancomycinand ampicillin

17
Q

B. Fragilis

3rd gen

A

Ceftizoxime,

Moxolactam

18
Q

Cross BBB except

3rd Gen

A

Cefoperazone,
Cefixime,
Ceftibuten and
Cefpodoxime proxetil

19
Q

ORAL

3rd gen

A

Cefixime,
cefdinir,
ceftibuten &
cefpodoxime

20
Q

N. Gonorrhea

3rd gen

A

Ceftriaxone (DOC) 125 mg inj. IM; and Cefixime, single 400 mg

21
Q

DOC severe Lyme disease

3rd gen

A

Ceftriaxone

22
Q

DOC for Klebsiella, Enterobacteriaceae, Proteus, Providencia, Serratia, Haemophilus

3rd gen

A

3rdgen cephalosporin: +/-aminoglycosides

23
Q

3 rd generation with ____________for Rx of meningitis caused by P. aeruginosa

A

aminoglycoside

24
Q

3rd gen with__________ for meningitis due to non-penicillin susceptible pneumococci

A

Vancomycin

25
Q

has failed pneumococcal meningitis

3rd gen

A

Cefatoxime

26
Q

More resistant to hydrolysis by chromosomal B-lactamases (eg. those produced by Enterobacter) but can be hydrolyzed by extended spectrum B-lactamases

A

Fourth gen

27
Q

Penetrates CSF

A

4th gen

28
Q

Highly active against Haemophilus and Neisseria

A

4th gen

29
Q

prodrug of ceftaroline and ceftobiprole medocaril

A

Ceftaroline fosamil

30
Q

Cephalosporin that contains a methyl thiotetrazolegroup –cause disulfiram like reactions, hypoprothrombinemiaand bleeding disorders

AE

A 
Cefamandole, 
Moxolactam, 
Cefmetazole, 
Cefoteta, 
Cefoperazone)

With antidote of vitamin K

31
Q

interferes with platelet function, severe bleeding

AE

A

Moxolactam

32
Q

Gonorrhea
Gonococcal urethritis, disseminated gonococcal infection
Opthalmia neonatorum

A

Ceftriaxone

33
Q

Pneumococcal pneumonia

A

3rd gen or vancomycin

34
Q

Pneumococcal meningitis

A

3rd gen + vancomycin

35
Q

Salmonella

A

Ceftriaxone or Fluoroquinolone

36
Q

Memorize mo muna lahat ng generation

A

Nasa ppt

Pharmacology 2nd Sem Prelim (7 decks)

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