Beta Lactam Antibiotics And Vancomycin

Question 1

What is the target of beta lactam antibiotics and vancomycin?

Answer 1

They attack cell wall synthesis

Question 2

Give 3 examples of beta lactam antibiotics

Answer 2

Penicillins, cephalosporins and carbapenems

Question 3

Why must penicillin G be injected?

Answer 3

Because it is acid labile

Question 4

Give two examples of penicillins that are sensitive to beta lactamase degradation

Answer 4

Penicillin G and Ampicillin

Question 5

True or false, ampicillin is acid stable so can be administered orally?

Answer 5

True

Question 6

Which class of beta lactamase enzymes is amoxicillin resistant to?

Answer 6

Class 1

Question 7

Which two penicillins are resistant to all beta lactamases?

Answer 7

Methicillin and Flucloxacillin

Question 8

Which type of bacteria are the cephalosporins active against?

Answer 8

Gram negative

Question 9

True or false, third generation cephalosporins are administered orally?

Answer 9

False- second generation are administered orally, third generation are injected

Question 10

What is the mechanism of action of vancomycin?

Answer 10

Prevents cell wall peptides interacting with each other and forming cross links

Question 11

Give the uses of vancomycin

Answer 11

Serious gram positive infections only, can be used for MRSA, oral vancomycin is used for clostridium dificile infections