Benzodiazepines 2

Question 1

Alprazolam - clinical uses

Answer 1

Anxiety, panic disorder

Question 2

Benzodiazepines used for anxiety disorders

Answer 2

Alprazolam
Chlordiazepoxide
Clonazepam
Diazepam
Lorazepam
Oxazepam

Question 3

Benzodiazepines used for insomnia

Answer 3

Estazolam
Flurazepam
Temazepam
Triazolam

Question 4

Benzodiazepines used for alcohol detoxification

Answer 4

Chlordiazepoxide

Diazepam

Question 5

Chlordiazepoxide - indications

Answer 5

Alcohol detoxification, anxiety

Question 6

Benzodiazepines used in seizure disorders

Answer 6

Clonazepam
Diazepam
Lorazepam

Question 7

Clonazepam - indications

Answer 7

Anixiety, panic disorder.

Seizure disorders

Question 8

Diazepam - indications

Answer 8

Alcohol detoxification, anxiety, muscle spasms, seizure disorders spasticity. Terminate recurrent seizures

Question 9

Lorazepam - indications

Answer 9

Anxiety, seizure disorders

Question 10

Midazolam - indications

Answer 10

Anesthesia for e.g. endoscopy, minor surgery

Question 11

Oxazepam - indications

Answer 11

Anxiety

Question 12

Benzodiazepines - adverse effects

Answer 12

Abrupt withdrawal: seizures. Arrhythmia, CNS depression, drug dependence, hypotension, mild respiratory depression

Question 13

Which benzodiazepines are more likely to cause drug hangover?

Answer 13

Chlordiazepoxide
Diazepam
Flurazepam

Question 14

Estazolam, flurazepam, tamazepam and triazolam - adverse effects

Answer 14

Hypersensitivity (anaphylaxis, angioedema), complex sleep-related behaviors (driving, phone calls, sex, making/eating food)

Question 15

Which benzodiazepine is less and which is more likely to cause rebound insomnia?

Answer 15

Least likely: Flurazepam

Most likely: Triazolam

Question 16

Bezodiazepines - interactions

Answer 16

All: Alcohol and other CNS depressants - potentiated effect.
Most: Cimetidine increases and rifampin decreases serum levels

Question 17

Benzodiazepines with interactions differing from the rest

Answer 17

Alprazolam: Fluoxetine & fluvoxamine - increase serum levels.
Midazolam: CCB, erythromycin, ketoconazole increase serum levels.
Triazolam: Cimetidine, erythromycin, ketoconazole and oral contraceptives increase serum levels.

Question 18

Which benzodiazepines interact with cimetidine and rifampin?

Answer 18

Interact with both: Chlordiazepoxide, clonazepam, diazepam, estazolam, flurazepam, temazepam.
Interact with rifampin: Lorazepam, oxazepam.