Barbiturates

Question 1

Barbiturates - 4 drugs

Answer 1

Amobarbital
Pentobarbital
Thiopental
Phenobarbital

Question 2

Barbiturates - MOA

Answer 2

Bind to allosteric site on GABAA receptor-chloride ion channel. Increase the affinity of the receptor for GABA and duration for the channel to be open.
Also act directly to increase chloride influx in the absence of GABA.

Question 3

Barbiturates - effects

Answer 3

Respiratory depression, coma, death.
Anxiolytic effect associated with considerable sedation.
Do not cause significant muscle relaxation.
Suppress slow-wave and REM sleep.v

Question 4

Barbiturates - contraindications

Answer 4

Porphyria

Question 5

Barbiturates - adverse effects

Answer 5

CNS depression.
Respiratory depression, coma, death.
Daytime sedation and hangover.
Physical dependence, withdrawal syndrome

Question 6

Barbiturates - interactions

Answer 6

Induce cytochrome P450, accelerate their own and other drugs metabolism.
Induce α-aminolevulinate - exacerbate porphyria.
Potentiate effects of other CNS depressants.

Question 7

Short-acting barbiturate(s)

Answer 7

Pentobarbital, thiopental

Question 8

Medium-acting barbiturate(s)

Answer 8

Amobarbital

Question 9

Long-acting barbiturate(s)

Answer 9

Phenobarbital

Question 10

Which barbiturates are indicated for insomnia?

Answer 10

Amorbital, pentobarbital

Question 11

Phenobarbital - indications

Answer 11

Seizure disorders

Question 12

Thiopental - indications

Answer 12

Induction for anesthesia

Question 13

Barbiturates - administratino

Answer 13

Amobarbital, pentobarbital, phenobarbital: oral adm.

Thiopental: IV