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19 Sedative, hypnotic, anxiolytic drugs > Antihistamines > Flashcards

Antihistamines Flashcards

1
Q

Antihistamines used as sedatives and anxiolytics

A

Diphenhydramine
Hydroxyzine
Doxepin

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2
Q

Antihistamines - MOA

A

Bind to H1 receptors and reduce ACh release in reticular neuclei.

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3
Q

Diphenhydramine - indications

A

Insomnia (found in sleep-preparations)

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4
Q

Antihistamines - adverese effects

A

Anticholinergic effects (blurred vision, dry mouth, urinary retention, dizziness, drowsiness)

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5
Q

Antihistamines - interactions

A

Alcohol, barbiturates, CNS depressants potentiate CNS effects

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6
Q

Hydroxyzine - indications

A

Anxiety, sedation

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7
Q

Doxepin - indications

A

Insomnia

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8
Q

Nonsedating anxiolytic drugs - 2 drugs

A

Buspirone

Propanolol

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9
Q

Buspirone - MOA

A

Partial agonist at serotonin 5-HT1A receptors, activates feedback-inhibition of serotonin release. Causes up-regulation of postsynaptic serotonin receptors

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10
Q

Buspirone - indications

A

Chronic anxiety

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11
Q

Buspirone - adverse effects

A

Dizziness, drowsiness, nervousness

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12
Q

Propanolol - indications in anxiety

A

Situational or performance anxiety

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13
Q

Propanolol - Adverse effects

A

Bradycardia, bronchoconstriction, depression, fatigue, hypersensitivity, hypotension, impaired glycogenolysis, vivid dreams

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14
Q

Propanolol - interactions

A

Cardiac depression is increased by CCBs

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19 Sedative, hypnotic, anxiolytic drugs (6 decks)

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