Benign Swellings Flashcards
What is acanthosis?
Increase layer of prickle cell
What is epithelial atrophy?
Reduction in thickness epithelium
What is often seen in epithelial atrophy?
Loss of rete ridges
What is hyperkeratosis?
Increase thickness of normal keratin - at site usually keratinised
What is keratosis?
Keratinisation of non-keratisied epithelium
What is epithelial hyperplasia?
Increase thickness of epithelium thickness
What is granulation tissue?
Fibrous tissue - fibroblasts and endothelial cells
Occur in response to trauma
What do fibroblast cells look like in granulation tissue?
Spindle cells
Role of fibroblasts in granulation tissue?
Lay down collagen?
What tissue expect to see in pyogenic granuloma histologically?
Granulation tissue
Fibroblasts/ endothelial cells
May see inflammatory cells
What features would see histologically pyogenic granuloma?
Granulation tissue
May ulcerated surface w/ fibrous-purulent slough
Cause of pyogenic granuloma?
Trauma or irritation (e.g plaque/ denture/ ortho appliance)
What can predispose people to pyogenic granuloma?
Hormonal exacerbation
What is the management of pyogenic granuloma?
Excision - care in preganncy
Removal cause - e.g increased OH
What is the predominant tissue in fibrous epulis?
Fibrous connective tissue
Causes fibrous epulis?
Trauma/ irritation
Management fibrous epulis?
Excision and removal of cause
Where in mouth expect to see giant cell lesion?
Usually anterior
What histologically would indicated giant cell lesion?
Multi-nucleated giant cells
Expect see vascular tissue w/ haemorrhage
What need to exclude if histologically dx giant cell lesion?
If peripheral or central
How exclude central giant cell lesions?
PA/ radiographs - if lesion in bone
Blood test
What condition can appear to be associated with central giant cell lesions?
Hyperparathyroidism - increase PTH can cause similar histology
How would squamous cell papilloma look?
White cauliflower like growth - well defined
What expect if see multiple cauliflower looking growths?
Possible immuno-suppressions e/g HIV
How dose histological appearance papilloma contribute clinical appearance?
Increase hyper-keratinised tissue - white appearance
Folded projections = cauliflower like appearnace
What is cause of squamous cell papilloma?
HPV
6 or 11 - non-oncogenic
Which HPV is oncogenic?
16/18
Manage squamous cell papilloma?
Excision of margins and reassure
