behcet's disease

Question 1

definition of behcet’s disease

Answer 1

inflammatory multisystem disease featuring a triad of orogenital ulceration and uveitis

Question 2

aetiology of behcet’s disease

Answer 2

unknown

HLA-B51 and ancestry from Turkey, Greece central Asia

Question 3

investigations for behcet’s disease

Answer 3

pathergy test - needleprick becomes inflamed and a sterile pustule develops in 24-48hr

complement levels

FH

Question 4

sx of behcet’s

Answer 4

recurrent oral and genital ulceration

uveitis

skin lesions eg erythema nodosum, papulopustular lesions

arthritis (non-erosive large joint oligoarthropathy)

thrombophlebitis

vasculitis

myo/pericarditis

CNS involvement (pyramidal signs)

colitis