Behavioural Data

Question 1

Why behavioural data were absent from 7 patient?

Answer 1

This was either because the patient attended the appointment without an informant or else carers/relatives were distressed and it was deemed inappropriate to approach them.

Question 2

Which group exhibited more behavioural changes than the other patient groups, except in the domain of eating and drinking

Answer 2

Patients with SD

Question 3

in frequency of behavioural changes in SD patients with predominantly right and predominantly left-sided atrophy there was?

Answer 3

No difference.

Question 4

Behavioural changes were ? to SD?

Answer 4

not exclusive to SD and some patients in each group exhibited changes in each category of behaviour evaluated.

Question 5

What was the only expectation?

Answer 5

The only exception was that no patient with lvPPA exhibited altered ‘response to environment’.

Question 6

Group differences reached significance for the following behavioural domains: ?

Answer 6

response to environment’ (Fisher’s exact test, p = .018), ‘social behaviour’ (Fisher’s exact test, p = .038) and ‘hobbies, order and routine’ (Fisher’s exact test, p = .015).

Question 7

Changes in ‘hobbies, order and routine’ were more common in ?

Answer 7

SD than nfvPPA, lvPPA, and AD

Question 8

and changes in patients’ ‘response to their environment’ were more common ?

Answer 8

in SD than lvPPA.

Question 9

Changes in ‘social behaviour’ were more common in SD than ?

Answer 9

AD.

changes in these behavioural domains had relatively high sensitivities and specificities for SD

Question 10

A large proportion of patients with nfvPPA, lvPPA, and AD exhibited ?

Answer 10

withdrawal in social behaviours and interaction with others, in particular, a relatively high proportion of lvPPA (44.4%) and nfvPPA (40.0%) patients enjoyed being with others less.

Question 11

In contrast, a high proportion of SD patients enjoyed

Answer 11

being with others more (42.9%).

Question 12

Changes in social emotions were more prevalent in

Answer 12

nfvPPA and SD patients than in lvPPA or AD.

Question 13

The majority of SD patients (57.1%) showed reduction in ? And increase?

Answer 13

showed a reduction in the range of food they eat and an increase in the following features: reaction to painful stimuli (66.7%), clockwatching (57.1%), simple (71.4%) and complex (66.7%) repetitive behaviours, following a daily routine (57.1%), and enjoyment of puzzles (71.4%).

Question 14

an increase in these features ( reaction to pain stimuli, clockwatching, repetitive behaviours etc.) occurred in the other patient groups?

Answer 14

Rarely.

Nevertheless just under a third of nfvPPA patients liked TV quizzes and sweet food more than previously.

Question 15

Fourteen patients had missing data on at least one of the 25 test variables due ?

Answer 15

to anxiety/ the magnitude of their difficulties and had to be excluded from the PCA.

Question 16

The remaining 33 patients comprised ?

Answer 16

9 nfvPPA, 7 lvPPA, 7 SD, and 10 multi-domain AD.

Question 17

Which factor did not yield group differences?

Answer 17

Factor two = Tests of verbal/phonological working memory loaded heavily onto factor two.

Question 18

Patients with nfvPPA scored significantly lower on factor ?

Answer 18

factor one (the ‘speech production/grammaticality’ factor) than patients in the other groups and

Question 19

Patients with SD scored higher on factor ?

Answer 19

three (the ‘semantic/behaviour’ factor) than patients with nfvPPA, lvPPA, or AD

Question 20

Scores for factors 1–3 for the 33 patients were entered into a LDA to determine ?

Answer 20

how well the factors derived from the PCA were able to differentiate the three diagnostic groups

Question 21

How many discriminant functions were obtained?

Answer 21

Three.

Question 22

How many discriminant functions

were statistically significant ?

Answer 22

Two of three.

Question 23

The discriminant model correctly classified ?

Answer 23

72.7% of patients (88.9% of nfvPPA patients, 42.9% of lvPPA patients, 71.4% of SD, and 80.0% of multi-domain AD patients

Question 24

The model showed 88.9% sensitivity and 100.0% specificity for diagnosing

Answer 24

NfvPPA

Question 25

The sensitivity for diagnosis of SD was

Answer 25

71,4% with a specificity of 96.2%.

Question 26

The sensitivity for diagnosis of lvPPA was ?

Answer 26

42,9% with a specificity of 96.2%.

Question 27

The sensitivity for diagnosis of multi-domain AD was

Answer 27

80.0% with a specificity of 69.6%.

Question 28

Two patients with SD were predicted to be in the ?

Answer 28

AD group

Question 29

One patient with nfvPPA was predicted to be in the

Answer 29

AD group

Question 30

Four patients with lvPPA were predicted to be in the ?

Answer 30

AD group

Question 31

One patient with AD was predicted to be in the ?

Answer 31

lvPPA group and a further patient with AD was predicted to be in the SD group.

Question 32

While the model using the three factors was reasonably accurate at classifying ? it was unable to distinguish between the ?

Answer 32

nfvPPA and SD,

multi-domain AD and lvPPA groups