Bcell effector response Flashcards
What is the primary immune response?
when a naive b cell first sees its Ag
What are characterized by the first immune response?
IgM production
How kong doe sit take for the first immune response?
~7-10 days
What happens to B cells during/after this response?”
b cells often class switch
What is the secondary response?
Memory response
What characterizes the secondary respons?
production of IgG or other Isotypes affinity matiration (hypermutation)
How long does a secondary response take?
1-3 days
Does the secondary response need t cell help?
yes
primary response doesnt need it but works better with it
What is the germinal center?
area where mature B cell development occurs
What are follicular dendritic cells?
do not present Ag to T cells (don’t express MHC class II) “trap” antigen but don’t internalize (to keep it around longer)
What is the function of antibody function?
pathigen neutralization complement fixation antibody dependent cellular cytotoxcity opsonization inflamation
what is complement fixation?
inflammation,
opsonization,
cell lysis
What is antibody dependent cellulare cytotoxity?
death by NK cells, neutrophils, eosinophils
presence of FcR on these cells
what is opsonoization?
stimulation of phagocytosis (primarily macrophages)
agglutination (cells) or precipitation (soluble) of Ag
