BBB penetrability of Antibx

Question 1

Good only w/ inflammation

Answer 1

Penicillins
Cephalosporins (Cefuroxime, 3rd-4th gen)
Imipenem+cilastatin
Meropenem
Aztreonam
Ciprofloxacin
Vancomycin

Question 2

Minimal or not good even w/ inflamm

Answer 2

Aminoglycosides
Tetracyclines
Lincosamides
Macrolides

Question 3

No passage even w/ inflamm

Answer 3

Polymixins
1st and 2nd gen cephalosporins
Amphotericin B

Question 4

DOC for neonatal meningitis

Answer 4

Ampicillin + Amikacin (penicillin + aminoglycoside)

Question 5

Why is an aminoglycoside used for tx of neonatal meningitis?

Answer 5

Neonates still have an immature BBB.

Question 6

Why are cephalosporins not used for neonatal meningitis?

Answer 6

One of the pathogens causing meningitis is Listeria monocytogenes, w/c is not covered by the drug.

Question 7

Cephalosporins are NOT active against:

Answer 7

MRSA
L. monocytogenes
Enterococci

Question 8

Chloramphenicol is a bacteriostatic drug but is bacteriCIDAL against what?

Answer 8

Neisseria meningitidis
Bacillus fragilis
Streptococcus pneumoniae
Hemophilus influenzae
(NBSH= No Bf Since HS)

Question 9

MOAs of the bactericidal action of aminoglycosides

Answer 9

Inhibition of initiation of translation
Incorporation of incorrect AA
Premature termination of translation
(Binitin. Niloko. Iniwan.)

Question 10

Excellent w/ or w/o inflammation

Answer 10

Sulfonamides
Chloramphenicol
Trimethroprim
Metronidazole
Rifampicin
Isoniazid
Fluconazole
Flucytosine