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BLOOD BANK SEM > BB LEMAR NOTES (P4-P6) > Flashcards

BB LEMAR NOTES (P4-P6) Flashcards

1
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: A1

A

POSSIBLE GENOTYPES: A1A1, A1O, A1A2

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2
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: A2

A

POSSIBLE GENOTYPES: A2A2, A2O

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3
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: A1B

A

POSSIBLE GENOTYPES: A1B

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4
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: A2B

A

POSSIBLE GENOTYPES: A2B

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5
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: B

A

POSSIBLE GENOTYPES: BB; BO

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6
Q

(MAJOR ABO GENOTYPES AND PHENOTYPES)

P: O

A

POSSIBLE GENOTYPES: OO

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7
Q

(FORMATION OF ABH ANTIGENS)

GENE: H
GLYCOSYLTRANSFERASE: ?

A

L-fucosyltransferase

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8
Q

(FORMATION OF ABH ANTIGENS)

GENE: A
GLYCOSYLTRANSFERASE: ?

A

N-acetylgalacctosaminyltransferase

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9
Q

(FORMATION OF ABH ANTIGENS)

GENE: B
GLYCOSYLTRANSFERASE: ?

A

D-galactosyltransferase

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10
Q

(FORMATION OF ABH ANTIGENS)

GENE: AB
GLYCOSYLTRANSFERASE: ?

A

N-acetylgalactosaminyltransferase ; D-galactosyltransferase

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11
Q

(FORMATION OF ABH ANTIGENS)

GENE: H
IMMUNO DOMINANT SUGAR: ?

A

L-fucose

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12
Q

(FORMATION OF ABH ANTIGENS)

GENE: A
IMMUNO DOMINANT SUGAR: ?

A

N-acetyl-D-galactosamine

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13
Q

(FORMATION OF ABH ANTIGENS)

GENE: B
IMMUNO DOMINANT SUGAR: ?

A

D-galactose

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14
Q

(FORMATION OF ABH ANTIGENS)

GENE: AB
IMMUNO DOMINANT SUGAR: ?

A

N-acetyl-D-galactosamine; D-galactose

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15
Q

(FORMATION OF ABH ANTIGENS)

GENE: H
ANTIGEN: ?

A

H

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16
Q

(FORMATION OF ABH ANTIGENS)

GENE: A
ANTIGEN: ?

A

A

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17
Q

(FORMATION OF ABH ANTIGENS)

GENE: B
ANTIGEN: ?

A

B

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18
Q

(FORMATION OF ABH ANTIGENS)

GENE: AB
ANTIGEN: ?

A

AB

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19
Q

(FORMATION OF ABH ANTIGENS)

GENE: O
ANTIGEN: ?

A

UNCHANGED H

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20
Q

GREATEST AMOUNT TO LEAST AMOUNT OF H ANTIGEN

A

O > A2 > B> A2B> A1> A1B>

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21
Q

4 different forms of H antigens:

A

H1, H2, H3, H4

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22
Q

unbranched straight chains of H antigens

A

H1, H2

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23
Q

complex branched chains of H antigens

A

H3, H4

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24
Q

WHAT TYPE OF CHAIN?

Linkage: Beta 1,3
Origin: Plasma
Controlling Genes: H, A, B, Se, and Lewis

A

TYPE 1

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25
WHAT TYPE OF CHAIN? Linkage: Beta 1,4 Origin: Synthesized on erythrocytic precursors Controlling Genes: H, A, B
TYPE 2
26
(SUBGROUPS OF A) WHAT BLOOD GROUP? Antigen Present: A, A1 Anti-A: + Anti-A1 Lectin: +
A1
27
(SUBGROUPS OF A) WHAT BLOOD GROUP? Antigen Present: A Anti-A: + Anti-A1 Lectin: -
A2
28
What subgroup of A? Branched a antigens 2 million a antigens/adult red cells Positive with anti-A Positive with anti-A1 lectin
A1`
29
What subgroup of A? Linear a antigens 500,000 a antigens/adult red cells Positive with anti-A Negative with anti-A1 lectin
A2
30
(OTHER SUBGROUPS OF A) Mixed field agglutination with anti-A and/or anti-AB
A3
31
(OTHER SUBGROUPS OF A) Weak agglutination with anti-AB only
Ax
32
(OTHER SUBGROUPS OF A) ≤10% red cells show very weak mixed field agglutination
Aend
33
(OTHER SUBGROUPS OF A) No agglutination with Anti-A and anti-AB, secretors demonstrates quantities of A substance in saliva
Am
34
(OTHER SUBGROUPS OF A) No agglutination with Anti-A and anti-AB, secretors contain small amount of A substance in saliva
Ay
35
(OTHER SUBGROUPS OF A) No agglutination with Anti-A and anti-AB, secretors contain only H substance and no A substance in saliva
Ael
36
(SUBGROUPS OF B) mixed field agglutination with anti-B and/or anti-AB
B3
37
(SUBGROUPS OF B) Agglutination with anti-AB (wk/0 with anti-B)
Bx
38
(SUBGROUPS OF B) No agglutination with anti-B and anti-AB, secretors demonstrates quantities of B substance in saliva
Bm
39
(SUBGROUPS OF B) No agglutination with anti-B and anti-AB, secretors contain only H substance and no B substance in saliva
Bel
40
mistaken group O
Bombay phenotype
41
what is the genotype of bombay phenotype
hh
42
genotype that is very rare, does not make transferase to form the H antigen
hh
43
In bombay phenotype, RBCs fail to react with?
anti-A, anti-B, or anti-H lectin
44
In bombay phenotype, serum contains ____, _____, _____, and _____ (potent, reacts strongly at 37 deg. celsius)
anti-A, anti-B, anti-A,B and anti-H
45
In bombay phenotype only blood from other ________ can be transfused
bombay phenotype
46
(FORWARD GROUPING IN BOMBAY PHENOTYPE) GROUP O REACTION Anti-A: ?? Anti-B: ?? Anti-H: ??
Anti-A: 0 Anti-B: 0 Anti-H: +
47
(FORWARD GROUPING IN BOMBAY PHENOTYPE) GROUP Oh REACTION Anti-A: ?? Anti-B: ?? Anti-H: ??
Anti-A: 0 Anti-B: 0 Anti-H: 0
48
(REVERSE GROUPING IN BOMBAY PHENOTYPE) GROUP O REACTION A1 CELLS: ?? B CELLS: ?? O CELLS: ??
A1 CELLS: + B CELLS: + O CELLS: 0
49
(REVERSE GROUPING IN BOMBAY PHENOTYPE) GROUP Oh REACTION A1 CELLS: ?? B CELLS: ?? O CELLS: ??
A1 CELLS: + B CELLS: + O CELLS: +
50
Rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present
Para bombay
51
In para-bombay, the RBCs of the individuals express ______________, which are primarily detected by ______ and ________ studies
weak forms of A and B antigens ; adsorption and elution studies
52
In para-bombay, if a person is genetically ___ or ___, the respective enzymes can be detected, but no ___ enzyme is detectable, even though it has been shown that there is limited production of H antigen on the RBCs
A or B ; H
53
(SECRETOR STATE) ABO GROUP SECRETOR: A ABH SUBSTANCE IN SALIVA: ??
A, H substances
54
(SECRETOR STATE) ABO GROUP SECRETOR: B ABH SUBSTANCE IN SALIVA: ??
B, H substances
55
(SECRETOR STATE) ABO GROUP SECRETOR: AB ABH SUBSTANCE IN SALIVA: ??
A, B, H
56
(SECRETOR STATE) ABO GROUP SECRETOR: O ABH SUBSTANCE IN SALIVA: ??
H substance
57
(SECRETOR STATE) ABO GROUP SECRETOR: Nonsecretor (sese) ABH SUBSTANCE IN SALIVA: ??
NONE
58
Fluids in which ABH substances can be detected in secretors
Saliva Tears Urine Digestive Juices Bile Milk Amniotic Fluid Pathological Fluid: pleural, peritoneal, pericardial, ovarian cyst
59
(ACQUIRED ANTIGENS) reportd in persons of type O or B in association with severe infections caused by Proteus mirabilis
Acquired A Antigen
60
(ACQUIRED ANTIGENS) Tn-activated erythrocytes (polyagglutination)
Acquired A Antigen
61
(ACQUIRED ANTIGENS) Associated with conditions such as carcinoma of the colon or rectum, intestinal obstruction, massive infection of the lower gastrointestinal tract, and septiciemia caused by proteus vulgaris.
ACQUIRED B ANTIGEN
62
(ACQUIRED ANTIGENS) Can also result from increased permeability of the intestinal wall and subsequent absorption of bacterial polysaccharide (Escherichia coli O86) on the erythrocyte.
ACQUIRED B ANTIGEN
63
GROUP A WITH ACQUIRED B ANTIGEN FORWARD GROUPING: Anti-A: ? Anti-B: ?
Anti-A = 4+ Anti-B = 1+
64
GROUP A WITH ACQUIRED B ANTIGEN REVERSE GROUPING A1 Cells = ? B Cells = ?
A1 Cells = 0 B Cells = 4+
65
RESOLUTION FOR GROUP A WITH ACQUIRED B ANTIGEN:
1. Determine px's diagnosis and transfusion history. 2. Test px's serum against autologous red cells. (Anti-B in the ppx's serum does not agglutinate autologous red cells with the acquired B antigen) 3. Test red cells with additional monoclonal anti-B reagents from other manufacturers that are documented not to react with the acquired B antigen or a source of human polyclonal anti-B.
66
(ABO ANTIBODIES) Igm Reacts at RT Naturally-occurring Cant cross placenta Produce Anti-B Antibody
BLOOD GROUP: A
67
(ABO ANTIBODIES) Igm Reacts at RT Naturally-occurring Cant cross placenta Produce Anti-A Antibody
BLOOD GROUP: B
68
(ABO ANTIBODIES) Predominantly IgG Reacts at 37 deg.C Immune antibody Can cross placenta Produce Anti-A, Anti-B, Anti-AB antibodies
O

BLOOD BANK SEM (4 decks)

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