Basics of CPTP

Question 1

Define zero order kinetics

Answer 1

Drug will kill a constant number of tumour cells

Question 2

CLINICAL drug development phase 1

Answer 2

Test in healthy volunteers

confirm phamaokinectics

check for potential drug interactions, doses

Question 3

CLINICAL drug development phase 2

Answer 3

Test in patients

Establish potential therapeutic value and common adverse effects

Question 4

CLINICAL drug development phase 3

Answer 4

Large scale trials in patient

Compare with placebo
Establish common adverse effects at planned therapeutic dose

Question 5

What does licensing take into account when evaluating drug

Answer 5

Risk benefit

doesnt account for cost

Question 6

Who to report drug interactions to

Answer 6

MHRA

Medicines and Healthcare regulatory agency

Question 7

Drug rep sales promotion tactics must comply with code of conduct from who

Answer 7

ABPI

Association of British Pharmaceutical Industry

Question 8

ABCDE of adverse drug reactions

Answer 8

Augmented
Bizzare
Chronic tx effects
Delayed effects
End of treatment

Question 9

AUGMENTED adverse drug reactions

Answer 9

Dose related, avoidable

eg warfarin causing bleeding

Question 10

BIZZARE adverse drug reactions

Answer 10

Not dose related. Not predictable

(eg
chloramphenicol causing agranulocytosis,
penicillin causing allergy,
carbamezapine causing Steven Johnson)

Question 11

CHRONIC TX EFFECTS adverse drug reactions

Answer 11

Occur with prolonged tx

eg steroids leading to osteoporosis

Question 12

DELAYED EFFECTS adverse drug reactions

Answer 12

Occur some time after discontinuation of treatment

eg drug induced foetal anomalies

Question 13

END OF TREATMENT EFFECTS adverse drug reactions

Answer 13

Occur after withdrawing drug

eg adrenal insufficiency after steroid tx

Question 14

at which phase are drug developments usually detected

Answer 14

Phase 4