Basics

Question 1

Types of Neurones

Answer 1

1. Principal cells/ Interneurons
2. Golgi Type 1
3. Golgi Type 2

Question 2

Primary types of Glial cells

Answer 2

1. Astrocytes
2. Oligodendrocytes
3. Tanycytes
   - > Microglia

Question 3

Roles of astrocytes

Answer 3

1. Structural
2. Glycogen fuel reserve
3. BBB
4. Metabolic support
5. Regulation of ion conc.

Question 4

Ependyma

Answer 4

thin neuroectodermal lining of the ventricular system of the brain

• > 1/4 types of ependymal cells
• > CSF production

Question 5

Tanycyte

Answer 5

Specialed ependyma cell found in 3rd ventricle + floor of 4th to hypothalamus

Question 6

How do we categorise synapses?

Answer 6

Gray type 1 - asymmetric

Gray type 2 - symmetric

Question 7

What are the output possible projections of the medium spiny neurone?

Answer 7

External Globus pallidus, internal globus pallidus/ primary substantia nigra

Question 8

What are the inputs to the medium spiny neurone?

Answer 8

Cerebral cortex, thalamus, substantia nigra

Question 9

Why type of cells are medium spiny neurones?

Answer 9

GABAergic inhibitory cell in the striatum

Question 10

Primary phenotypes of MSNs

Answer 10

1. D1 direct pathway

2. D2 indirect pathway

Question 11

Direct pathway MSNs…

Answer 11

excite ultimate basal ganglia output structure

- express: D1, A1 (adenosine), dynorphin peptides + substance P

Question 12

Indirect pathway MSNs…

Answer 12

Inhibit output structure

- express: D2, A2A, DRD2-A2A heterotramers + enkephalin