Basal Ganglia and Cerebellum Function in Motor Planning

Question 1

five structures of the basal ganglia

Answer 1

caudate nucleus, putamen, globus pallidus, Subthalamic nucleus, substantial nigra

Question 2

which two structures are the striatum

Answer 2

caudete nucleus and the putamen

Question 3

which NT are involved in the basal ganglia

Answer 3

Glut, Gab, Dop, Acetylcholine

Question 4

what does DA do to the direct pathway

Answer 4

activate it - stimulatory - leads to movement inititation

Question 5

wbat does DA do to the indirect pathway

Answer 5

movement inhibition - inhibits it

Question 6

direct pathway acetylcholine -

Answer 6

Have inhibitory m4 Ach receptor so inhibit

Question 7

indirect pathway Ach

Answer 7

have excitatory M1 Ach receptotr so stimulate

Question 8

Parkinsons disease is caused by

Answer 8

loss of DA neurons projecting from Snpc to Striatum

Question 9

Parkinsons means

Answer 9

direct pathway less active, indirect pathway increased

Question 10

treatment of Parkinsons

Answer 10

Ldopa

Question 11

Huntingtons disease caused by

Answer 11

excessive CAG repeats

Question 12

Huntingtons causes waht

Answer 12

Loss of gaba neurons in the striatum - leads to loss of inhibitoin

Question 13

where does the cerebellum receive info from

Answer 13

cerebral cortex, basal ganglia

Question 14

role of cerebellum

Answer 14

modifies movements/motor commands

Question 15

how many layers are in the cerebellum

Answer 15

3

Question 16

what are the five types of neurons in the cerebellum

Answer 16

purkinje, gransular, basket, stellate, golgi

Question 17

purkinje cells are

Answer 17

inhibitory (gabaergic neurons)

Question 18

perkinje cells are the sole

Answer 18

output neurons

Question 19

perkinje cells receive input from two excitatory inputs

Answer 19

parallel fibers, climbing fibers