Basal Ganglia anatomy Flashcards

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1
Q

What 5 parts make up the Basal Ganglia

A

Caudate

Putamen

Substantianigra

Subthalamic Nucleus

Globus Pallidus

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2
Q

What is the Striatum made up of?

A

Caudate and Putamen

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3
Q

What is the Caudate and Putamen referred to as?

A

The main input nuclei

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4
Q

Where does the basal ganglia receive its information from?

A

Cerebral cortex

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5
Q

What are the Globus Pallidus and Substantianigria referred to as?

A

The main output nuclei

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6
Q

Where does the basal ganglia send its information

A

Cerebral cortex via thalamus or brainstem

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7
Q

What is the main inhibitory output of the basal ganglia?

A

outputs from the globus pallidus inhibiting the thalamus to prevent unwanted movements

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8
Q

what does the basal ganglia direct pathway do?

A

silences neurons in the Globus pallidus freeing the thalamus from the inhibitory effect

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9
Q

what does the basal ganglia indirect pathway do?

A

increases suppression of unwanted movements

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10
Q

What do microglia cells do in the brain?

A

act as macrophages (respond to inflammation / damage)

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11
Q

What is the most common glial cell found in the brain?

A

Astrocytes (highly specialised depending on location within brain)

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12
Q

What do astrocytes do in the brain?

A

help transmission of information and control immune response of brain.

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13
Q

What do oligodendrocytes form and do?

A

Myelin sheets on the nerve axons which speed up transmission

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14
Q

What are the 3 common neurotransmitters found in the brain?

A

Serotonin

Dopamine

Noradrenaline

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15
Q

What is Sertonin’s main output site and what does it do?

A

Raphe nucleus

Arousal, Sensory processing, Mood, Emotion

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16
Q

What is Dopeamine’s main output site and what does it do?

A

Substantia nigra, Ventral tegmental nucelus

Motivation, Motor control, Memory, Learning

17
Q

What is Noradrenaline’s main output site and what does it do?

A

Cerulus necleus

Arousal, Attention, Memory, Pain, Stress

18
Q

How is serotonin (5-HTP) synthesised?

A

from AA trytophan

19
Q

How is serotonin produced limited?

A

Many other AA’s aswell as trytophan also try and cross the blood brain barrier

20
Q

How is serotonin production regulated?

A

A feedback loop based on how much serotine is present in the synaptic cleft

21
Q

What enzymes is involved in serotonin synthesis

A

trytophan-hydroxylase & 5-hydrotryptophan-decarboxylase

22
Q

What are the main 4 Dopamine pathways

A

LC - Thalamus - hypothalamus

LC - cerebral cortex (PFC, cingulum)

LC - amydgala - hippocampus

LC - cerebellum - spinal cord

23
Q

What are the 3 main Noradrenaline pathways?

A

Nigrostriatal

Mesolimbic

Mesocortical

24
Q

What are the 4 main Serotonin pathways?

A

Rostral raphe - cerebral cortex

Rostral raphe - basal ganglia/thalamus

Rostral/caudal raphe - cerebellum

Rostral/caudal raphe - spinal cord

25
Q

What is basic motor pathway called?

A

Corticospinal tract

26
Q

What are the two divisions of the corticospinal tract?

A

The lateral portocale tract