Bacteria Virulence Factors Functions

Question 1

Corynebacterium Diptheriae

Answer 1

AB toxin inhibits human protein synthesis via ADP ribosylation (A inhibits ribosome function, B allows binding and penetration of A subunit)

Question 2

Pseudomonas Aeruginosa

Answer 2

Exotoxin A: inactivates elongation factor (EF-2), Endotoxin: fever, shock

Question 3

Shigella

Answer 3

ST inactivates 60S ribosome by cleaving rRNA

Question 4

EHEC (Enterohemorrhagic E. Coli - 0157:H7)

Answer 4

Toxin inactivates 60S ribosomal subunit by cleaving rRNA

Question 5

ETEC (Enterotoxigenic E. Coli) - Type 1

Answer 5

LT overactivates adenylate cyclase through increased cAMP

Question 6

ETEC (Enterotoxigenic E. Coli) - Type 2

Answer 6

ST overactivates guanylate cyclase leading to increased cGMP

Question 7

Bacillus anthracis

Answer 7

Edema factor mimics adenylate cyclase enzyme leading to increased cAMP leading to edema

Question 8

Vibrio cholerae

Answer 8

Overactivates adenylate cyclase leading to increased cAMP by permanently activating Gs

Question 9

Bordetella Pertussis

Answer 9

Overactivates adenylate cyclase leading to increased cAMP by disabling Gi

Question 10

Clostridium Tetani

Answer 10

Tetanospasmin causes cleavage of SNARE protein

Question 11

Clostridium botulinum

Answer 11

Botulinum causes cleavage of SNARe protein required for neurotransmitter release

Question 12

Clostridium perfringens

Answer 12

Phospholipase that degrades tissue cell membranes

Question 13

Haemophilus influenzae

Answer 13

Inflammatory reaction to capsule