Bacteria and virulence factors

Question 1

Porphyromonas gingivalis

Answer 1

Capsule–protection against phacocytosis
Assachrolytic
Fimbrae–attachment to host cell
Collagenase–degrade CT
Endotoxin LPS–activates cytokines
Cell toxic substances acetate, hydrogen sulphide
Specific cytotoxins –reduce chemotaxis, phagocytosis
Specific proteases –degrade complement proteins
Invasins–penetrate into tissues
Black pigmented bacteriorides—periodontal disease

Question 2

Aggregatibacter actinomycetemcomitans

Answer 2

Leukotoxin metabolite–kills WBC
Bacteriocins –kills actinomyces and strep
Cytotoxins –inhibit fibroblast proliferation
Invasins –Penetrates phagocytes
Adhesins–Attachment to teeth
Capsule–Protection against phagocytosis
Endotoxins–bone resorption and inflammation
Chemotaxis inhibitor–inhibits neutrophils
Collagenase–degrade connective tissue

Question 3

Tannerella forsythia

Answer 3

Serrated S layer–invade epithelium of oral cavity
Produces endotoxins
Induces apoptotic cell death
Trypsin like proteolytic activity