Background

Question 1

What is the annual incidence/prevalence of laryngeal cancer?

Answer 1

Occurs in 12,000 Americans (1/4-1/3 of all head and neck cancer cases) per year. 4,200 cancer related deaths annually.

Question 2

What is the annual incidence/prevalence of hypopharyngeal cancer?

Answer 2

~ 2500

Question 3

What is the 5 yr survival across all stages for laryngeal cancer?

Answer 3

~ 60%

Question 4

What is the 5 yr survival across all stages for hypopharyngeal cancer?

Answer 4

~ 30%

Question 5

Risk factors of larynx cancer?

Answer 5

smoking, GERD, occupation based on voice

Question 6

Risk factors of hypopharyngeal cancer?

Answer 6

alcohol abuse, chronic voice strain, vitamin C and iron def (Plummer-Vinson syndrome)

Question 7

What is the incidence of cancer in each subsites of larynx?

Answer 7

2/3 are glottic, 1/3 supraglottic, 1-2% subglottic

Question 8

What is unique in terms of hypopharyngeal cancer’s risk

Answer 8

Alcohol seems to be a stronger associated risk factor than smoking for hypopharyngeal