B6.034 Vasculitis

Question 1

primary vasculitis

Answer 1

not causes by another disease process

Question 2

secondary vasculitis

Answer 2

resulting from another systemic process

Question 3

common vasculitis mimics

Answer 3

clotting disorders: antiphospholipid syndrome
noninflammatory vascular disorders: Ehlers Danlos (type 4), SAM, FMD
occlusion of blood vessels by traveling clot/air/particle
atherosclerosis
infections

Question 4

secondary causes of vasculitis

Answer 4

drugs
malignancies
infections
connective tissue diseases
-RA
-sjogrens
-inflammatory myositis
-sarcoidosis

Question 5

classes of primary vasculitides

Answer 5

large vessel
medium vessel
immune complex small vessel
ANCA associated small vessel

Question 6

what is pulmonary renal syndrome

Answer 6

diffuse alveolar hemorrhage + glomerulonephritis

Question 7

etiologies of pulm renal syndrome

Answer 7

GPA
MPA
EGPA
sarcoidosis
SLE
anti GBM (goodpasture)

Question 8

what is goodpastures syndrome

Answer 8

anti-glomerular basement membrane Abs (IgG)

antibodies against NC1 domain of a3 chain of type 4 collagen

Question 9

targets of goodpastures

Answer 9

kidneys and lungs

Question 10

how is goodpastures similar to anca associated vasculitis

Answer 10

same histology

different immunofluorescent staining (linear in anti-GBM)

Question 11

ANCAs

Answer 11

p-ANCA = MPO elisa
c-ANCA = PR3 elisa

Question 12

causes of cryoglobulinemic vasculitis

Answer 12

3-11% idiopathic
majority are secondary
-infection (75-92%)
-autoimmune
-hematologic malignancies

Question 13

manifestations of cryoglobulinemic vasculitis

Answer 13

skin: palpable purpura, raynauds
arthralgia
peripheral neuropathy
renal