B6.007 Large Group

Question 1

correlation between hereditary hemochromatosis and arthritis

Answer 1

associated with calcium pyrophosphate disease (CPPD or pseudogout)

Question 2

what is hereditary hemochromatosis

Answer 2

autosomal recessive mutation in HFE (chromosome 6) resulting in iron overload
mutation in C282Y

Question 3

prevalence of HH

Answer 3

0.5% homozygous in Caucasian population

Question 4

clinical manifestations of HH

Answer 4

liver abnormalities
fatigue
skin hyperpigmentation (iron + melanin)
DM
cardiomyopathy
secondary osteoarthritis
hypopituitarism

Question 5

diagnosis of HH

Answer 5

iron/TIBC >45%
OR
elevated ferritin
HFE phenotype after iron studies

Question 6

xray hand findings in HH

Answer 6

hooked osteophytes
sclerotic change
chondrocalcinosis in triangular fibrocartilage

Question 7

xray knee findings in HH

Answer 7

chondrocalcinosis
asymmetric joint space narrowing
osteophytes
subchondral sclerosis

Question 8

when to consider atypical OA

Answer 8

young age (30-40s)
location of joints (elbow, MCPs, ankle)
comorbidities