B6-077 Bone Tumors Flashcards
all bone tumors derive from what cell origin?
osteoblasts
pain at night relieved by NSAIDs
osteoid osteoma
pain unresponsive to NSAIDs
osteoblastoma
benign tumor that prefers the axial skeleton
osteoblastoma
occurs in children
typically long bones
benign mass
osteoid osteoma
bimodal distribution
likes long bones and face bones
osteosarcoma
codman’s triangle
conventional osteosarcoma
treatment of osteoid osteoma
radiofrequency ablation
treatment of osteoblastoma
curettage or resection
osteosarcoma treatment
wide resection and chemotherapy
<2 cm bony mass
osteoid osteoma
> 2cm bony mass
osteoblastoma
cartilage tumors in the digits are nearly always
benign
cartilage tumors in the pelvis and axial skeleton are nearly always
malignant
lobules with reactive bone at periphery
enchondroma
chondroblasts permeate existing bone
chondrosarcoma
low-grade chondrosarcoma in the long bones is
atypical cartilaginous tumor
atypical cartilaginous tumor treatment
curettage
chondrosarcoma treatment
wide resection
**does not respond to chemo
medullary continuity
osteochondroma
lateral bony projections of growth plate
recapitulates growth plate
osteochondroma
enchondroma leaves the cortex […]
intact
fibrous dysplasia is caused by
congenital somatic mutation
is fibrous dysplasia well differentiated?
yes
streamers of bone
low grade central osteosarcoma
spicules of bone in continuity with bone
fibrous dysplasia
is low grade central osteosarcoma well differentiated?
no, its permeative
treatment of fibrous dysplasia
none
low grade central osteosarcoma treatment
wide resection, no chemo
occurs in 10% of population
in children, around knee
benign, usually go away on there own
non-ossifying fibroma
affects skeletally mature patients at epiphysis
giant cell tumor of bone
storiform architecture
foamy histiocytes
non-ossifying fibroma
huge multinucleate giant cells
nuclei of cells in stroma look like nuclei of the giant cells
giant cell tumor of bone
cyst that is well demarcated and doesn’t really expand bone
simple bone cyst
cyst that rapidly expands bone
Aneursymal Bone Cyst
serous filled cyst
simple bone cyst
blood filled cyst
Aneursymal Bone Cyst
cyst that is a cellular tumor
Aneursymal Bone Cyst
cyst that is an acellular tumor
simple bone cyst
normal sized giant cells
spindle cells
bone spiculations
Aneursymal Bone Cyst
osteomyelitis is often located in the
metaphysis
small round cell tumor
Ewing sarcoma
EWSR1-FLI1
ewing sarcoma
normal bone with lymphocytic infiltrate
osteomyelitis
giant cells
spindle cells in storiform pattern
foamy macrophages
metadiaphyseal region
non-ossifying fibroma
necrotic bone
neutrophils (lymphocytic infiltate)
osteomyelitis
blood circulation is richest where?
near growth plate
osteomyelitis in a child is likely to present in what part of bone?
near growth plate
cartilage neoplasms of the digits are likely to be
enchondromas
multinucleated giant cells
stromal cells have nuclei that appear cytologically similar
giant cell tumor of bone
marrow continuity
osteochondroma
largely acellular (small lesion, big cyst)
mostly fibrin/fibrous walls
simple bone cyst
most common benign bone tumor
typically occurs in males <25
osteochondroma
benign tumor that occurs in the metaphysis of long bones
osteochondroma
continuous with marrow space
covered by cartilage cap
osteochondroma
.
.
benign tumor that occurs in the cortex of long bones
adults <25
males > females
osteoid osteoma
presents as bone pain relieved by NSAIDs
bony mass <2cm with radiolucent core
osteoid osteoma
typically occurs in the vertebrae
males > females
osteoblastoma
bony mass >2cm
pain unresponsive to NSAIDs
osteoblastoma
typically occurs in the medulla of small bones of hand and feet
benign tumor of cartilage
chondroma
benign tumor that occurs in the epiphysis of long bones (knee region)
20-40 year olds
giant cell tumor
osteosarcoma typically occurs in what age range?
males <20 years
malignant tumor occurring in metaphysis of long bone
osteosarcoma
presents as painful enlarging mass or pathologic fracture
pleomorphic, osteoid producing cells
osteosarcoma
malignant tumor more commonly occurring in adults > 50
chondrosarcoma
malignant tumor that commonly occurs in the medulla of pelvis, proximal femur, and humerus
chondrosarcoma
usually lytic, with intralesional calcifications, endosteal erosion, and cortex breach
malignant tumor of chondrocytes
chondrosarcoma
generally occurs in patients <15 in the
diaphysis of long bones (especially femur)
Ewing sarcoma
anaplastic small blue cells of mesenchymal origin
Ewing sarcoma
