B3.3 Muscle and mobility Flashcards
What is movement?
Movement is one of the 8 characteristics of life(MRHMGREN) but movement can either refer to movements that can take place within the bode (e.g. peristalsis) or by moving an organism from one place to another(locomotion)
What is a sessile organism?
Sessile organism (e.g. barnacles or corals or planta-mimosa pudica) do not perform locomotion – they remain in a fixed position but move individual body parts.
What is a motile organism?
Motile organism move around while feeding within their territory – some further distances than others.
E.g. mammals, bacteria, squid/octopus
What do muscles fibres contain?
Muscle fibers contain many parallel myofibrils, which consist of a series of sarcomeres.
What are sarcomeres?
A sarcomere is the repeating unit of a muscle cell.
What cause the contraction of sarcomeres?
The contraction of sarcomeres, and therefore a muscle, is due to the sliding of actin and myosin filaments.
What are sarcolemma and sarcoplasma, in respect to the sliding filament model of contraction?
The sarcolemma and sarcoplasma are specific adaptations of the cell membrane and cytoplasm, respectively.
What is the sarcoplasmic reticulum?
A specialised (modified) endoplasmic reticulum, the sarcoplasmic reticulum, is a fluid filled system of membranous sacs surrounding the muscle myofibrils.
What is the function of the sarcoplasmic reticulum?
Wrapped around myofibrils, its function is to store calcium ions, and comes to action when conveying a signal to contract all parts of the muscle fibres.
What does the sarcolemma contain?
The sarcolemma has multiple tunnel-like extensions that penetrate the interior of the cell, called T-tubules.
What are between the myofibrils?
Between the myofibrils are large number of mitochondria, which provide ATP needed for contraction.
What causes the pattern of light and dark bands in sarcomeres?
The pattern of light and dark bands in sarcomeres is due to a precise and regular arrangement of actin and myosin filaments.
What happens during a muscle contraction?
A muscle contraction shortens each sarcomere and therefore the overall length of the muscle fibre. The contraction occurs by sliding of actin and myosin filaments.
Describe the changes that occur to the sarcomere during muscle contraction/relaxation.
When muscle fibers contract the sarcomere length shortens and the Z-discs move closer together. When the muscle is relaxed, the sarcomere length is longer.
What are skeletal muscles composed of?
A bundle of striated muscle fibres, each of them stimulated by a motor neuron.
What are muscle fibres?
Each muscle fibre is a multinucleated cell containing numerous myofibrils, which are highly ordered assemblages of thick myosin and thin actin filaments.
What causes muscles to contract or relax?
The release of calcium from sarcoplasmic reticulum (motor neuron–>nerve impulse) triggers muscle contraction.
What is the neuromuscular junction?
At the synapse (neuromuscular junction) the stimulus is converted into a chemical signal using acetylcholine as a neurotransmitter. One motor neuron with multiple branches connecting to a number of muscle fibre. This results in a coordinated contraction.
What are muscle fibres composed of?
Myofibrils which contain sarcomeres, and it contains a specialised cytoplasm called sarcoplasm.
What is a sarcomere?
The basic contractile unit of a muscle containing actin(thin filament) and myosin (thick filament).
Inside a sarcomere there are protein filaments called actin and myosin. These two fibrous structures are largely responsible for facilitating a muscle contraction: Describe the features of the thick and thin protein filaments.
The thin filament is made up of two twisted chains of the globular protein actin.
The thick filament is made of many molecules of the protein myosin. Each myosin molecule has a fibrous tail and a globular head. It has an actin binding site and an ATPase binding site.
Explain how the sliding filament mechanism and cross-bridges of muscle fibres result in a muscle contraction.
The sliding filament theory explains contraction of a sarcomere. According to this theory, when a muscle is stimulated to contract, actin filaments slide over the myosin filaments towards centre of the sarcomere. This results in:
- 2-discs being pulled closer together. shortening sarcomere + resulting in overall shortening of muscle fibres
- H bands + I bands decrease length as actin is pulled inwards, overlapping more myosin + reducing area where only myosin or actin is present
How does a contraction begin and how does that result in sarcomere shortening?
Muscle contraction initiated by the brain via an action potential which causes an influx calcium ions that bind to troponin. Without electrical stimulation, myosin binding sites on the actin filaments are blocked by a thin + fibrous protein subunit called tropomyosin. Tropomyosin runs alongside the action filament preventing binding of myosin to actin + hence preventing contraction of muscle. Tropomyosin is associated with another protein subunit called troponin. When a muscle is stimulated by a motor neuron, calcium ions are released from sarcoplasmic reticulum, a specialized endoplasmic reticulum that is found in sarcoplasm (cytoplasm) of muscle cells. These calcium ions bind to the troponin causing it to undergo a conformational change –> troponin moves tropomyosin away from myosin binding site, allowing myosin to bind to actin.
Why do the sarcomere shorten?
The shortening of the sarcomere comes about by the cocking of the myosin heads, when ADP and Pi is released. The breaking of the cross-bridges can only occur when a fresh molecule of ATP re-charges the myosin head.
What is the function of tropomyosin?
In addition to the contractile filaments myosin and actin, the myofibril also contains troponin protein complexes and tropomyosin fibers.
Tropomyosin covers the myosin binding sites, effectively preventing attachment of the myosin head. During a contraction, Ca2+ ions bind to troponin, which moves away the tropomyosin fibres.
What is titin?
Titin is the largest polypeptide being composed of 34350 amino acids. It is elastic and acts as a molecular spring.
Titin connects myosin filamints to the Z-discs.
What are the functions and contributions of titin to muscle contraction?
Titin connects myosin filaments to the Z-discs. It stores potential energy when it is stretched and releases it when it recoils - thereby adding to the force of contraction. It also prevents overstretching of the sarcomere and it holds the myosin filaments in place surrounded by 6 actin filaments.
What is the role of antagonistic muscle?
Energy is needed to stretch titin and therefore lengthen the muscle when relaxing. Energy cannot be supplied by the muscle itself because muscles can only exert force when contracting. The energy is therefore provided by another muscle called the antagonist.
E.g. In the elbow joint, the triceps and biceps muscles are an antagonistic pair. The biceps flexes the forearm, the triceps extends the forearm.
Compare exoskeleton and endoskeleton.
An exoskeleton takes over the function of bones for muscle attachment in arthropods.
An endoskeleton- internal skeleton.
What is the purpose of a skeleton?
-support
-shape
-protection