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IBI Test 3 > B3-073 CBCL Lymphoma > Flashcards

B3-073 CBCL Lymphoma Flashcards

1
Q

disease limited to 1 anatomic region or 2 contiguous regions on the same side of diapragm

A

stage 1

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2
Q

disease in more than two anatomic regions or in the noncontigous regions on the same side of the diaphragm

A

stage 2

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3
Q

disease on both sides of diapragm but limited involvement of lymph nodes and spleen

A

stage 3

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4
Q

disease of any lymph node with involvement of the liver, lung, and bone marrow

A

stage 4

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5
Q

waldenstrom macroglobinunemia

A

LPL

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6
Q

MYD88 L265P mutation

A

LPL

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7
Q

sIg +
CD5+
CD20+
CD23+

A

CLL/SLL

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8
Q

sIg+
CD20+
FMC7 +

A

Marginal zone

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9
Q

sIg+
CD10+
CD20+
FMC7+

A

follicular lymphoma

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10
Q

sIg+
CD5+
CD20+
FMC7+
cyclin D1+

A

mantle cell

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11
Q

sIg+
CD20+
FMC7+

A

LPL

lymphoplasmacytic lymphoma

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12
Q

t(14;18)

A

follicular lymphoma

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13
Q

t(11;18)

A

marginal zone lymphoma

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14
Q

t(11;14)

A

mantle cell lymphoma

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15
Q

positive SOX11 stain

A

mantle cell lymphoma

marker for cyclin D1 negative MCL

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16
Q

nucleus size more than twice of nomal lymphocyte

A

diffuse large b cell

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17
Q

occur in equatorial Africa

A

endemic Burkitt

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18
Q

t(8;14)

A

Burkitt lymphoma

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19
Q

which leukemia/lymphoma is most common in children

A

ALL

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20
Q

spreads in an orderly fashion to contiguous lymph node groups

A

Hodgkin

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21
Q

most common cell of origin for non-hodgkin lymphomas?

A

B cell

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22
Q

most common leukemia in US

A

CLL

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23
Q

lymphocytosis
smudge cells

A

CLL

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24
Q

blasts are associated with

A

AML or ALL

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25
Q

granulocytic leukocytosis is associated with

A

CML

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26
Q

circulating plasma cells characterizes

A

plasma cell leukemia

rare complication of plasma cell myeloma

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27
Q

presence of ……. is favorable for CLL

A

somatic hypermutation

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28
Q

t(14, 18)

A

follicular lymphoma

29
Q

t(14;18) causes overexpression of

A

Bcl-2

follicular lymphoma

30
Q

t(8;14)

A

Burkitt

31
Q

t(8;14) causes overexpression of

A

MYC

Burkitt

32
Q

t(11;14)

A

mantle cell

33
Q

t(11; 14) causes over expression of

A

cyclin D1

mantle cell lymphoma

34
Q

t(15;17)

A

APL

35
Q

trisomy 12

A

CLL

36
Q

t(11;18)

A

marginal zone lymphoma

37
Q

c-MYC is located on chromosome

A

8

38
Q

most common type of non hodgkin lymphoma

A

diffuse large B cell

follicular lymphoma is second most common

39
Q

second most common type of non-hodgkin lymphoma

A

follicular

40
Q
A

Burkitt

starry sky

41
Q

Burkitt lymphoma has a high association with what virus

A

EBV

42
Q

CD20+
CD10+
TdT-

A

Burkitt

43
Q

waldenstrom macroglobulinemia is associated with

A

Lymphoplastic lymphoma (LPL)

44
Q

monoclonal gammopathy of undetermined significance with an IgG or IgA paraprotein is most likely to transform into

A

plasma cell myeloma

45
Q

rouleux is associated with

A

plasma cell myeloma

46
Q

rouleux is caused by

A

large amount of paraprotein

47
Q

waldenstrom macroglobulinemia is associated with what paraprotein?

A

IgM

48
Q

BRAF mutation is associated with

A

hairy cell leukemia

49
Q

reed sternburg cells are diagnostic for

A

hodgkin

50
Q

CD15+
CD30+

A

hodgkin

51
Q

what immunophenotype do Hodgkins cells express?

A

CD15
CD30

52
Q

commonly occurs in young adults and adolescents

A

Hodgkin

53
Q

associated with HTLV-1 infection

A

adult t cell leukemia

54
Q

what 2 lymphomas are associated with CD5+?

A

mantle cell
SLL

55
Q

how to distinguish mantle cell from SLL?

A

mantle cell is
CD23-
Cyclin D1+
and
t(11;14)

56
Q

CD20+
CD5+
CD23-

A

mantle cell lymphoma

57
Q

what CDs characterize mantle cell lymphoma?

A

CD20+
CD5+
CD23-
CyclinD1 +

58
Q

[T/F] Hodgkin lymphoma has TCR rearrangement

A

false

59
Q

[T/F] T cell lymphomas are the most common non-Hodgkin lymphomas

A

false

B cell

60
Q

[T/F] CLL/SLL without transformation is considered aggressive

A

false

indolent

61
Q

[T/F] richters transformation is a rare complication of diffuse B cell lymphoma

A

false

CLL/SLL

62
Q

[T/F] low grade follicular lymphoma can transform to more aggressive double or triple hits lymphoma

A

true

63
Q

[T/F] mantle cell lymphoma is characterized by monoclonal B cells that are CD5 and cyclin D1 positive

A

True

64
Q

[T/F] richters transformation of CLL/SLL can be diffuse large B cell lymphoma of Hodgkin lymphoma

A

true

65
Q

[T/F] IgH gene rearrangement is present in mantle cell lymphoma

A

true

66
Q

[T/F] hodgkin lymphoma includes classical and nodular lymphocyte dedominant subtypes

A

true

67
Q

[T/F] NK cell lymphoma has both TCR and IgH rearrangement

A

false

68
Q

t(11;18)

A

marginal zone lymphoma

IBI Test 3 (20 decks)

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