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IBI Test 3 > B3-043 Plasma Cell Myelomas > Flashcards

B3-043 Plasma Cell Myelomas Flashcards

1
Q

neoplasms of terminally differentiated, immunoglobin secreting plasma cells

A

plasma cell neoplasm

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2
Q

M component

A

monoclonal immunoglobin

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3
Q

multifocal destructive infiltration of plasma cells in bone marrow

A

multiple myeloma

plasma cell myeloma

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4
Q

M component without features of myeloma

1% a year transform to multiple myeloma

A

monoclonal gammopathy of undetermined significance

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5
Q

CRAB criteria

A

hyperCalcemia: bone pain, fractures
Renal disease
Anemia, thrombocytopenia
punched out Bone lesions

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6
Q

primary cause of death for plasma cell myeloma

A

infection or renal disease

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7
Q

monoclonal immunoglobin or light chain
serum free light chains
rouleaux formation

A

plasma cell myeloma

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8
Q

protein found in urine in plasma cell myeloma

A

Bence Jones protein

monoclonal free light chain

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9
Q

if the y band on electrophoresis has wide distribution

A

polyclonal

nonspecific marker

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10
Q

if the y band on electrophoresis has narrow distribution

A

hypogammaglobinemia

consider further evaluation for paraprotein

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11
Q

a monoclonal band on electrophoresis indicates

A

M protein

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12
Q

y band on electrophoresis indicates

A

immunoglobins, CRP

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13
Q

immunofixation electrophoresis can determine

A

Ig class
and
detect M protein

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14
Q

measurement by nephelometry using antibody to a region of the light chain not normally accessible in intact immunoglobin molecules

A

free kappa and lamba chains

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15
Q

can confirm monoclonality
determines light chain class

A

kappa:lambda ratio

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16
Q

disease progression and monitoring

A

kappa and lambda levels

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17
Q

urine protein electrophoresis has [higher/lower] sensitivity for MFLC/BJP

A

lower

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18
Q

urine immunofixation has [higher/lower] sensitivity for MFLC/BJP

A

higher

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19
Q

24-h urine studies

A

detect monoclonal free light chains (MFLC) and Bence Jones protein

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20
Q

direct measurement from SPE
serum free light chains
urinary MFLC/BJP

A

m-protein

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21
Q

flow cytometry
kappa/lambda immunohistochemistry

A

bone marrow clonal plasma cells

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22
Q
A

rouleaux

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23
Q

> 10% monoclonal plasma cells
nodules or diffuse sheets of plasma cells

A

plasma cell myeloma

24
Q

CD38+
CD138+

A

plasma cell myeloma

25
Q
A

kappa lambda staining of plasma cell myeloma

26
Q
A

plasma cell myeloma

note eccentric nuclei

27
Q

cast nephropathy

A

plasma cell myeloma

light chain aggregates form tubular casts

28
Q

plasma cell treatment

A

immunomodulators (thalidomide)
proteosoma inhibitors (bortezomib)
monoclonal antibodies (daratumumab)

theres a lot on the slide but these are what he focused on

29
Q

induction of plasma cell myeloma therapy should be followed by

A

hematopoietic stem cell transplant

30
Q

CD19
CD20
CD103

A

hairy cell leukemia

31
Q

myeloid markers

A

CD13
CD33
CD15
myeloperoxidase

32
Q

rearrangement of immunoglobin heavy chains is unique to

A

B lymphocytes

33
Q

VDJ recombination takes place in the

A

bone marrow

34
Q

initially, B lymphocytes produce

A

IgM

35
Q

the primary function of splenic red pulp is

A

filtration of defective/old RBCs

36
Q

t(8;14)

A

Burkitt

37
Q

diffuse infiltrate of small, non cleaved cells with high mitotic index, scattered histiocytes

A

Burkitt

38
Q

nodular architecture with small cell size

A

follicular

39
Q

diffuse architecture with small cell size

A

SLL

40
Q

sheets of plasma cells

A

plasma cell myeloma

41
Q

most neoplasms of small lymphocytes are

A

indolent

42
Q

aggressive small lymphocyte neoplasm

A

mantle cell

43
Q

are the cells in plasma cell myeloma monoclonal?

A

yes

44
Q

the presence of rouleux is due to

A

elevated serum protein

from elevated immunoglobin levels

45
Q

free monoclonal light chains in the urine are called

A

bence jones proteins

46
Q

bence jones proteins cause

A

renal damage

47
Q

patients with MGUS can transform into

A

plasma cell myeloma

48
Q

anemia and renal dysfunction

A

plasma cell myeloma

49
Q

most common type of monoclonal immunoglobin in myeloma is

A

IgG, followed by IgA

50
Q

B cell lymphomas that produce monoclonal immunoglobin usually produce

A

IgM

rarely IgG

51
Q

translocations involving cyclin D1 are favorable for

A

plasma cell myeloma

52
Q

translocations involving …. are favorable for plasma cell myeloma

A

cyclin D1

53
Q

what small molecule inhibitors are effective in plasma cell myeloma?

A

proteosome

increase apoptotic death due to accumulation of misfolded immunoglobins

54
Q

CD38

A

plasma cell myeloma

55
Q

what CD marker is characteristic of plasma cell myeloma?

A

CD38

IBI Test 3 (20 decks)

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