B2.1 membrane and membrane transport Flashcards

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1
Q

phospholipid bilayer

A

consists of phosphate and fatty acids
( hydrophilic polar head and hydrophobic non polar tail)

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2
Q

micelle

A

phospholipid bilayer shaped in a circle, wth hydrophobic area in the centre and membrane enclosed structures

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3
Q

libosome

A

circular membrane
enclosed structure
hydrophobic area and hydrophilic area
2 circles

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4
Q

amphiapathic properties

A

both polar and non polar properties in the same structure

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5
Q

why do phospholipids clump together

A

non polar regions clump together on the inside of the bilayer,polar regions (head) move towards the outside of the bilayer where they contact with water

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6
Q

fluid mosaic bilayer

A

flexible, resistant and ability to change shape
composition of many structural molecules embeded in the bilayer such: proteins carbs and cholesterol

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7
Q

structure of plasma cell membrane

A

1) phospholid bilayer
2) polar head and tail
3) cholesterol
4) carbohydrate group
5) glycolipid
6) integral transmembrane protein
7) integral protein
8) peripheral protein
9) glycoprotein

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8
Q

what does cholesterol do

A

regulates the fluidity of the membrane

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9
Q

what does glycolipid do

A

acts as cell receptors and/or recognition

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10
Q

what does integral transmembrane protein and integral protein do

A

function as channels pumps and enzymes
integral means permently associated with cell membrane

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11
Q

receptor protein

A

these membrane proteins recognize and respond to chemical signals from outside the cell. when the chemical signal binds, the membrane protein triggers a response by the cell

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12
Q

example of receptor protein

A

insulin receptor protein is a hormone released by the pancreas when blood sugar levels are high. inslulin binds to the isulin receptor protein, which then allows glucose to enter cell from blood

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13
Q

adhesive proteins

A

proteins that achor the cell membrane to:
the inner cytoskeleton
proteins outside the cell
other cells

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14
Q

examples of adhesive proteins

A

desmone proteins are found in muscles tissue where they bind muscle cells to one another

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15
Q

recognition protein

A

these membrane proteins serve as identification tags on the surface of the cell. these are often “glycoproteins” with the carbohydrate portion projecting out of the cell and into the extracellular space. these give the cell a biochemical personality and are important in cell-to-cell recognition

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16
Q

regocnision protein examples

A

imunoglobulins or antibodies b cells carry antibodies embeded by the tail in the outer cell membrane, with the binding sites facing outwards. this enables the b cells to bind to antigens

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17
Q

channel protein

A

these membrane allow small molecules to pass through the cell membrane by creating a pore through the membrane.

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18
Q

channel protein examples

A

proteins called aquaporin allows water molecules to move through the cell membrane single file

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19
Q

pump protein

A

.these proteins function to move small molecules or ions across the cell membrane by creating a pore through the membrane.
crate concentration gradient- energy from low to high

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20
Q

pump protein examples

A

the calcium pump allows muscles to relax after contraction y moving calcium ions back into th

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21
Q

enzyme protein

A

Membrane proteins show enzymatic activity and catalyse reactions.

22
Q

example of enzyme protein

A

ATP sythase builds atp by adding phosphate group to adp

23
Q

exocytosis

A

the secretion of macromolecules produced within the cell ( inside the RER) to the extracellular fluid without going through the phospholipid bilayer

24
Q

examples of exocytosis

A
  • secretion of neurotransmiter at synapse
  • secretion of hormones from endocrine gland, such as insulin
  • secretion of digestive juices from exocrine glands in the mouth and stomach
  • secretion of blood plasma protein such as fibronogen from liver
  • release of cortical granuled from egg cell during fertilization
25
Q

step 1 exocytosis

A

macromolecules synthesized in the RER moves towards the golgi complex by being packed within a transport vesicle.
these vesicles contain the same membrane composition as plasma membrane

26
Q

step 2 of exocytosis

A

transport vesicles fuse with the embrane of the golgi complex, that modifies macromolecules. from the gogi, a new vesicle is formed by budding of the membrane and releasing secretory vesicle

27
Q

step 3 of exocytosis

A

secretion of the macromolecule happens when the sceretory vesicle fuses with the cell membrane, releasing its contents to the outside of the cell.
+ a increase in the plasma membrane as the membrane of the vesicle fuses with it

28
Q

endocytosis

A

the intake of macromolecules from the extracellular fluid to the cytoplasm without passing through the phospholipid bilayer

29
Q

examples of endocytosis

A

-phagocytosis- engulfing f any pathogen by a phagocyte
- pinocytosis-intake of liquid macromolecules such as tissue fluid
- receptor-mediated endocytosis: specific intake of macromolecules that will bind to a receptor at the plasma membrane. chlatin in the protein membrane allows specific molecules to be engulfed regulating a more specific intake of macromolecule

30
Q

endocytosis step 1

A

macromolecules in the extracellular fluid are engulfed by the plasma membrane, one this pinches off and packages the macromolecule inside an endosome. these vesicles contain the same mebrane composition of the protein membrane.

31
Q

endocytosis step 2

A

the endosome moves through the cytoplasm and fuses with the lysome

32
Q

endocytosis step 3

A

the lysome digests the contents using its enzymes. the products are used as building blocks for the cell

33
Q

simple diffusion

A

down concentration gradient from high to low

34
Q

osmosis

A

movement of water down concentration gradient from high to low water potential

35
Q

what are the membrane proteins used in osmosis

A

only in kidneys and ileum (aquaporin: problem channel)

36
Q

facilitated diffusion

A

down concentration gradient, uses selectively permable membrane
channels or carriers

37
Q

what molecules are moved through facilitated diffusion

A

channels: small hydrophobic molecules

carriers: small ionic molecules

38
Q

active transport

A

against concentration gradient, uses pump membrane protein

39
Q

how are non polar molecules moved

A

simple diffusiom

40
Q

how are polar molecules moved

A

facilotated diffusion

41
Q

how are macromolecules moved

A

active transport

42
Q

types of pumps

A
  • uniport= 1 movement in 1 direction
    -symport= more than 1 molecule in 1 direction
  • antiport= more than 1 molecule in both direction simeltaneously
43
Q

direct movement

A

energy is used to move molecule through the plasma membrane

44
Q

indirect movement

A

energy is used to move only 1 molecule while other molecule is cotransported just flows together along movement

45
Q

CAM’s

A

cell adhesion molecules: mostly cabrs, that link one cell to another by the formation of pores. they increase the communication between cells

46
Q

channel protein function

A

tube that lets small and hydrophilic molecules pass

47
Q

cholesterol function

A

membrane stiffener

48
Q

carrier protein function

A

gate lets small charged molecules and ionic molecules pass

48
Q

cytoskeleton function and composed of

A

microfiliments, microtubules
structural framework

49
Q

what happens with the change of temperature to the membrane

A

low temperature= hel, solif ordered phase
high temp= liquid disorders phase

49
Q

phospholipid molecule

A

major membrane molecule

50
Q

summary of proteins:
transport
receptor
adhesion
cell recognition
enzymes

A

transport- transport molecules across membrane
receptor-specifically binds to a molecule outside the cell, triggering a cell change
adhesion-anchors the cell membrane to protein outside the cell
cell recognition-acts on identifying cells
enzymes-break down substrates into products