B2.027 Wernicke-Korsakoff Syndrome Flashcards

1
Q

what are signs of WK syndrome?

A

confusion
nystagmus (eyes make repetitive uncontrolled movements)
opthalmoplegia (paralysis of ocular muscles)
ataxia (loss of full control over body movements)
short term mem loss
death

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2
Q

what is the first stage of WK syndrome?

A

Wernicke encephalopathy

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3
Q

what is the cause of Wernicke encephalopathy?

A

acute b1 (thiamin) deficiency

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4
Q

what is a treatment for Wernicke?

A

large doses of thiamin

200 mg per day (IV or oral)

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5
Q

if Wernicke is left untreated what does it progress to?

A

Korsakoff psychosis

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6
Q

what is the cause/effect of korsakoff?

A

demyelination of the limbic system

inability to remember new and old info

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7
Q

can korsakoff be reversed?

A

no, permanent brain damage

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8
Q

how many days of thiamin does the body store?

A

18

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9
Q

how is thiamin related to glucose metabolism?

A

thiamin is converted to active thiamin pyrophosphate in glial and neuronal cells
thiamin pyrophosphate serves as a cofactor for several enzymes in glucose metabolism pathways

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10
Q

what is the ultimate result of thiamine def due to impairment of glucose matabolism?

A

mitochondrial dysfunction and oxidative toxicity in the brain, beginning with areas of highest metabolic activity

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11
Q

should you restore glucose or thiamine first?

A

thiamine

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