B.12 FTD

Question 1

General Info

Answer 1

• heterogeneous disease
• Tau and TDP-43 involvement / FUS
• several subtypes
  Affected areas:
  Frontal and temporal regions
  -rarer than AD
  -C9orf72 identified

Question 2

Subtypes of FTD

Answer 2

Behavioural Variant:

• behavioural and personality changes
• executive functions impaired
• apathy, inhibition and loss of sympathy

Primary Progressive Aphasia:
-primarily language difficulties rather than behavioural

There are other subtypes but these display regions affected well
->different To AD

Question 3

FTD compared to AD

Answer 3

• later onset than AD
• different clinical timeline
• memory loss more prevalent in AD
• pre clinical amyloid build up with no clinical symptoms
• spatial orientation issues are more prevalent in AD
• fewer language issues in AD
• no hallucinations as compared to AD
• atrophy in other brain regions (posterior and hyppocampal regions in AD)
• rare genetic causes

Question 4

Overlap of FTD and ALS

Answer 4

FUS