B. 38 DMN

Question 1

History of DMN

Answer 1

-historically fMRI was used to find correlates for cognitive processes
-fmri is relative measure for activity
-resting state was used as baseline
HOWEVER
blood flow and activity have been reviewed and identified as DMN

->it is active by default without specific task

Question 2

Anti Correlational Networks

1

Answer 2

when one of these comes up the other one comes down

Positive:

• associated with cognitive tasks
• positive value in fMRI

Negative:

• network subtracted from network of interest
• mind wandering, resting state, memory

Neutral:
-activates with both negative and positive

Question 3

Positive Network

Answer 3

-Top Down attentional network (dorsal attention network)
-Bottom Up (ventral attention network)
and others
-lateral prefrontal and parietal areas

Question 4

Negative Network

Answer 4

Medial prefrontal and parietal areas

! DMN

Question 5

Neutral Network

Answer 5

primary senso and motor cortices

Question 6

DMN in Psychopathology

Answer 6

• altered in ASD: issues with self referential processing and theory of mind
• can be hyperactive and over connected in depression, OCD and schizophrenia
• in SZ unable to dampen down the DMN when need to do congnitive task (self commentary)
• patients have difficulties switching between networks

Question 7

DMN in AD

Answer 7

DMN activity reduces in healthy ageing

> reduced activity in AD and participants with high amyloid burden
-DMN dominates processind