Azole antifungals

Question 1

Azole MOA

Answer 1

Inhibition of cytochrome P-450 enzyme

Question 2

Catalyzes 14-a-demethylation of lanosterol to ergosterol

Answer 2

Cytochrome P-450 enzyme

Question 3

Canesten

Answer 3

Clotrimazole

Question 4

Broad spectrum

Tx tinea & candidiasis

Answer 4

Clotrimazole

Question 5

Severe GI disturbances

Answer 5

Clotrimazole

Question 6

Interferes w/ amino acid transport into the org by an axn of CM

Answer 6

Clotrimazole

Question 7

Spectazole

Answer 7

Econazole nitrate

Question 8

Femstat

Answer 8

Butoconazole nitrate

Question 9

Exelderm

Answer 9

Sulconazole nitrate

Question 10

Oxistat

Answer 10

Oxiconazole nitrate

Question 11

Vagistat

Answer 11

Tioconazole

Question 12

Tx vulvovaginal candidiasis

Answer 12

Tioconazole

Clotrimazole

Question 13

More effective against Torulopsis glabrata

Answer 13

Tioconazole

Question 14

Terazole

Answer 14

Terconazole

Question 15

For the control of vulvovaginal monolialiasis

Answer 15

Terconazole

Question 16

Daktarin

Answer 16

Miconazole nitrate

Question 17

Tx systemic fungal infxn & chronic mucocutaneous candidiasis

Answer 17

Miconazole nitrate

Question 18

Miconazole nitrate
Terconazole
SE

Answer 18

Thrombophlebitis
Pruritus
Fever
GI upset

Question 19

Nizoral

Answer 19

Ketoconazole

Question 20

1st orally active broad spectrum imidazole

Answer 20

Ketoconazole

Question 21

Useful for systemic infxn

Answer 21

Ketoconazole

Question 22

Hepatotoxic

Answer 22

Ketoconazole

Question 23

Sporanox

Answer 23

Itraconazole

Question 24

Orally active broad spectrum

Answer 24

Itraconazole

Question 25

Acidic envi requires for optimum absorption

Answer 25

Itraconazole

Question 26

Food enhances absorption

Answer 26

Itraconazole

Question 27

99% protein bound

Answer 27

Itraconazole

Question 28

Inc plasma conc of anti histamine

Answer 28

Itraconazole

Question 29

Impt alternative to Ketoconazole

Answer 29

Itraconazole

Question 30

Diflucan

Answer 30

Fluconazole

Question 31

Only water soluble azole w/ broad spectrum of activity

Answer 31

Fluconazole

Question 32

Excellent oral bioavailability

Answer 32

Fluconazole

Question 33

<10% plasma protein binding

Answer 33

Fluconazole

Question 34

Tx & prophylaxis of disseminated & deep organ candidiasis

Answer 34

Fluconazole

Question 35

Agent of choice in cryptococcal meningitis

Answer 35

Fluconazole

Question 36

DOC for Fungal meningitis

Answer 36

Fluconazole

Question 37

Other azoles

Answer 37

Voriconazole | Posoconazole