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Med Chem > Azole antifungals > Flashcards

Azole antifungals Flashcards

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1
Q

Azole MOA

A

Inhibition of cytochrome P-450 enzyme

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2
Q

Catalyzes 14-a-demethylation of lanosterol to ergosterol

A

Cytochrome P-450 enzyme

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3
Q

Canesten

A

Clotrimazole

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4
Q

Broad spectrum

Tx tinea & candidiasis

A

Clotrimazole

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5
Q

Severe GI disturbances

A

Clotrimazole

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6
Q

Interferes w/ amino acid transport into the org by an axn of CM

A

Clotrimazole

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7
Q

Spectazole

A

Econazole nitrate

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8
Q

Femstat

A

Butoconazole nitrate

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9
Q

Exelderm

A

Sulconazole nitrate

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10
Q

Oxistat

A

Oxiconazole nitrate

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11
Q

Vagistat

A

Tioconazole

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12
Q

Tx vulvovaginal candidiasis

A

Tioconazole

Clotrimazole

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13
Q

More effective against Torulopsis glabrata

A

Tioconazole

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14
Q

Terazole

A

Terconazole

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15
Q

For the control of vulvovaginal monolialiasis

A

Terconazole

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16
Q

Daktarin

A

Miconazole nitrate

17
Q

Tx systemic fungal infxn & chronic mucocutaneous candidiasis

A

Miconazole nitrate

18
Q

Miconazole nitrate
Terconazole
SE

A

Thrombophlebitis
Pruritus
Fever
GI upset

19
Q

Nizoral

A

Ketoconazole

20
Q

1st orally active broad spectrum imidazole

A

Ketoconazole

21
Q

Useful for systemic infxn

A

Ketoconazole

22
Q

Hepatotoxic

A

Ketoconazole

23
Q

Sporanox

A

Itraconazole

24
Q

Orally active broad spectrum

A

Itraconazole

25
Q

Acidic envi requires for optimum absorption

A

Itraconazole

26
Q

Food enhances absorption

A

Itraconazole

27
Q

99% protein bound

A

Itraconazole

28
Q

Inc plasma conc of anti histamine

A

Itraconazole

29
Q

Impt alternative to Ketoconazole

A

Itraconazole

30
Q

Diflucan

A

Fluconazole

31
Q

Only water soluble azole w/ broad spectrum of activity

A

Fluconazole

32
Q

Excellent oral bioavailability

A

Fluconazole

33
Q

<10% plasma protein binding

A

Fluconazole

34
Q

Tx & prophylaxis of disseminated & deep organ candidiasis

A

Fluconazole

35
Q

Agent of choice in cryptococcal meningitis

A

Fluconazole

36
Q

DOC for Fungal meningitis

A

Fluconazole

37
Q

Other azoles

A

Voriconazole

Posoconazole

Med Chem (5 decks)

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